Synthesis of [5,6-3H](+/-) gamma vinyl GABA

Synthetic Communications

Volumn 33, Issue 19, 2003, Pages 3327-3330

  Ahern, David G ^a   Laseter, Anne G ^a   Filer, Crist N ^a  

^a PERKINELMER INC   (United States)

Author keywords

Gamma vinyl GABA; Tritium

Indexed keywords

4 AMINOBUTYRIC ACID DERIVATIVE; TRITIUM; VIGABATRIN;

ARTICLE; DRUG SYNTHESIS; ENZYME DEGRADATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; REACTION ANALYSIS;

EID: 0042834053     PISSN: 00397911     EISSN: None     Source Type: Journal    
DOI: 10.1081/SCC-120023990     Document Type: Article

References (5)

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2. Lippert, B.; Metcalf, B.W.; Jung, M.J.; Casara, P. 4-Aminohex-5-enoic acid, a selective catalytic inhibitor of 4-aminobutyric acid amino-transferase in mammalian brain. Eur. J. Biochem. 1977, 74, 441.
3. Ahern, D.G.; Laseter, A.G.; Filer, C.N. An improved synthesis of 4-aminotetrolic acid. Synth. Commun. 2002, 32, 665.
4. Metcalf, B.W.; Casara, P. Regiospecific 1,4 addition of a propargylic anion. A general synthon for 2-substituted propargylamines as potential catalytic irreversible enzyme inhibitors. Tetrahedron Lett. 1975, 3337.
5. 3H] gamma vinyl GABA to GABA transaminase in brain homogenates. Life Sciences 1984, 34, 701.