No association between single nucleotide polymorphisms in DLX6 and Piccolo genes at 7q21-q22 and autism

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 119 B, Issue 1, 2003, Pages 98-101

  Nabi, Rafiqun ^a   Zhong, Hailang ^a   Serajee, Fatema J ^a   Mahbubul Huq, A H M ^a,b  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CHILDREN'S HOSPITAL OF MICHIGAN   (United States)

Author keywords

Forebrain development; Homeobox; Presynaptic matrix protein; Quantitative traits

Indexed keywords

ALLELE; ARTICLE; AUTISM; BRAIN DEVELOPMENT; CHROMOSOME 7Q; CONTROLLED STUDY; EXON; FOREBRAIN; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC MARKER; GENOME; HOMEOBOX; HUMAN; INHERITANCE; INTRON; LINKAGE ANALYSIS; MAJOR CLINICAL STUDY; PICCOLO GENE; PRIORITY JOURNAL; QUANTITATIVE GENETICS; QUANTITATIVE TRAIT; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 0042821582     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.10012     Document Type: Article

References (20)

1. Abecasis GR, Cardon LR, Cookson WO. 2000. A general test of association for quantitative traits in nuclear families. Am J Hum Genet 66:279-292.
2. Abecasis GR, Noguchi E, Heinzmann A, Traherne JA, Bhattacharyya S, Leaves NI, Anderson GG, Zhang Y, Lench NJ, Carey A, Cardon LR, Moffatt MF, Cookson WO. 2001. Extent and distribution of linkage disequilibrium in three genomic regions. Am J Hum Genet 68:191-197.
3. Abecasis GR, Cherny SS, Cookson WO, Cardon LR. 2002. Merlin-rapid analysis of dense genetic maps using sparse gene flow trees. Nat Genet 30:97-101.
4. Alarcon M, Cantor RM, Liu J, Gilliam TC, Geschwind DH. 2002. Evidence for a language quantitative trait locus on chromosome 7q in multiplex autism families. Am J Hum Genet 70:60-71.
5. Bailey A, Le Couteur A, Gottesman I, Bolton P, Simonoff E, Yuzda E, Rutter M. 1995. Autism as a strongly genetic disorder: Evidence from a British twin study. Psychol Med 25:63-77.
6. Betancur C, Leboyer M, Gillberg C. 2002. Increased rate of twins among affected sibling pairs with autism. Am J Hum Genet 70:1381-1383.
7. Davidovitch M, Patterson B, Gartside P. 1996. Head circumference measurements in children with autism. J Child Neurol 11:389-393.
8. Fenster SD, Chung WJ, Zhai R, Cases-Langhoff C, Voss B, Garner AM, Kaempf U, Kindler S, Gundelfinger ED, Garner CC. 2000. Piccolo, a presynaptic zinc finger protein structurally related to bassoon. Neuron 25:203-214.
9. Folstein SE, Rosen-Sheidley B. 2001. Genetics of autism: Complex aetiology for a heterogeneous disorder. Nat Rev Genet 2:943-955.
10. Folstein S, Rutter M. 1977. Infantile autism: A genetic study of 21 twin pairs. J Child Psychol Psychiatry 18:297-321.
11. Geschwind DH, Sowinski J, Lord C, Iversen P, Shestack J, Jones P, Ducat L, Spence SJ. 2001. The autism genetic resource exchange: A resource for the study of autism and related neuropsychiatric conditions. Am J Hum Genet 69:463-466.
12. Hauser ER, Boehnke M, Guo SW, Risch N. 1996. Affected-sib-pair interval mapping and exclusion for complex genetic traits: Sampling considerations. Genet Epidemiol 13:117-137.
13. Kruglyak L, Daly MJ, Reeve-Daly MP, Lander ES. 1996. Parametric and nonparametric linkage analysis: A unified multipoint approach. Am J Hum Genet 58:1347-1363.
14. Liu JK, Ghattas I, Liu S, Chen S, Rubenstein JL. 1997. Dlx genes encode DNA-binding proteins that are expressed in an overlapping and sequential pattern during basal ganglia differentiation. Dev Dyn 210:498-512.
15. O'Connell JR, Weeks DE. 1998. PedCheck: A program for identification of genotype incompatibilities in linkage analysis. Am J Hum Genet 63: 259-266.
16. Pfeffer U, Ferro P, Pavia V, Trombino S, dell'Eva R, Merlo G, Levi G. 2001. The coding region of the human DLX6 gene contains a polymorphic CAG/CCG repeat. Int J Oncol 18:1293-1297.
17. Pickles A, Bolton P, Macdonald H, Bailey A, Le Couteur A, Sim CH, Rutter M. 1995. Latent-class analysis of recurrence risks for complex phenotypes with selection and measurement error: A twin and family history study of autism. Am J Hum Genet 57:717-726.
18. Risch N, Spiker D, Lotspeich L, Nouri N, Hinds D, Hallmayer J, Kalaydjieva L, McCague P, Dimiceli S, Pitts T, Nguyen L, Yang J, Harper C, Thorpe D, Vermeer S, Young H, Hebert J, Lin A, Ferguson J, Chiotti C, Wiese-Slater S, Rogers T, Salmon B, Nicholas P, Myers RM. 1999. A genomic screen of autism: Evidence for a multilocus etiology. Am J Hum Genet 65:493-507.
19. Silverman JM, Smith CJ, Schmeidler J, Hollander E, Lawlor BA, Fitzgerald M, Buxbaum JD, Delaney K, Galvin P. 2002. Symptom domains in autism and related conditions: Evidence for familiality. Am J Med Genet 114:64-73.
20. Simeone A, Acampora D, Pannese M, D'Esposito M, Stornaiuolo A, Gulisano M, Mallamaci A, Kastury K, Druck T, Huebner K. 1994. Cloning and characterization oftwo members of the vertebrate Dlx gene family. Proc Natl Acad Sci USA 91:2250-2254.