The HELP system for the treatment of atherothrombotic disorders: A review

Therapeutic Apheresis

Volumn 7, Issue 4, 2003, Pages 391-396

  Jaeger, Beate Roxane ^a,b  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b NONE   (Germany)

Author keywords

Cardiovascular Diseases; Cholesterol (Reduction); Fibrinogen (Reduction); Myocardial infarction; Preeclampsia; Transplantation

Indexed keywords

HEPARIN;

APHERESIS; ATHEROSCLEROSIS; CORONARY ARTERY BYPASS GRAFT; CORONARY ARTERY DISEASE; DRUG SAFETY; HEALTH CARE; HEART INFARCTION; HEPARIN MEDIATED EXTRACORPOREAL LDL FIBRINOGEN PRECIPITATION; HUMAN; LIPID METABOLISM; MICROCIRCULATION; PRECIPITATION; PRIORITY JOURNAL; REVIEW; STROKE; THROMBOSIS;

CEREBROVASCULAR ACCIDENT; CORONARY ARTERIOSCLEROSIS; EXTRACORPOREAL CIRCULATION; FEMALE; FIBRINOGEN; FIBRINOLYTIC AGENTS; FOLLOW-UP STUDIES; HEPARIN; HUMANS; LIPOPROTEINS, LDL; MALE; MYOCARDIAL INFARCTION; PLASMAPHERESIS; PRECIPITATION; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 0042817881     PISSN: 10916660     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1526-0968.2003.00072.x     Document Type: Review

References (28)

1. Seidel D, Armstrong VW, Schuff-Werner P, Eisenhauer T. Removal of low-density lipoproteins (LDL) and fibrinogen by precipitation with heparin at low pH. Clinical application and experience. J Clin Apheresis 1988;4:78-81.
2. Eisenhauer T, Armstrong VW, Wieland H et al. Selective continuous elimination of low density lipoproteins (LDL) by heparin precipitation: First clinical application. Trans Am Soc Artif Intern Organs 1986;32:104-7.
3. Seidel D. The HELP System, a new therapeutic tool in the treatment of atherosclerosis. In: Seidel, D, ed. HELP Report 1994-10 years of clinical experience. MMV Medizin Verlag, GmbH München, 1994:1-12.
4. Jaeger BR, Seidel D. Hyperlipoproteinemia LDL Apheresis. Herz 2001;26:531-44.
5. DeGennes J-L, Touraine R, Maunand B, Truffert J, Laudat Ph. Formes homozygotes cutanéo-tendineuses de xanthomatose hypercholé sterolémique dans une observation familiale exemplaire. Essai de plasmaphérèse à titre de traitement héroique. Société Médicale Des Hôspiteaux Paris 1976;118:1377-402.
6. Stoffel W, Demant T. Selective removal of apolipoprotein B-containing serum lipoproteins from blood plasma. Proc Natl Acad Sci USA 1981;78:611.
7. Jaeger BR. Evidence for maximal treatment of atherosclerosis-Drastic Reduction of Cholesterol and Fibrinogen Restores Vascular Homeostasis. Ther Apher 2001;5:207-11.
8. Jaeger BR, Goehring P, Schirmer J et al. Consistent lowering of clotting factors for the treatment of acute cardiovascular syndromes and hypercoagulability - a different pathophysiologic approach. Ther Apher 2001;5:252-9.
9. Moriarty PM, Gibson CA, Shih J, Matia MS. C-reactive protein and other markers of inflammation among patients undergoing HELP LDL apheresis. Atherosclerosis 2001;158:495-8.
10. Jaeger BR, Tsobanelis T, Bengel F, Schwaiger M, Seidel D. Long-term prevention of premature coronary atherosclerosis in homozygous familial hypercholesterolemia. J Pediatr 2002;141:125-8.
11. Mellwig KP, Schmidt HK, Brettschneider-Meyer A et al. Koronare Herzkrankheit im Kindesalter bei familiärer Hypercholesterinä mie-Maximaltherapie unter Einsatz der LDL-Apherese. Der Internist 2003;44:476-80.
12. Seidel D, Armstrong VW, Schuff-Werner P, for the HELP Study Group. The HELP-LDL-apheresis multicentre study, an angiographically assessed trial on the role of LDL-apheresis in the secondary prevention of coronary heart disease. I. Evaluation of safety and cholesterol-lowering effects during the first 12 months. Eur J Clin Invest 1991;21:375-83.
13. Schuff-Werner P, Gohlke H, Bartmann Baggio G et al. The HELP-apheresis multicentre study, an angiographically assessed trial on the role of LDL-apheresis in the secondary prevention of coronary heart disease. II. final evaluation of the effect of regular treatment on LDL cholesterol plasma concentrations and the course of coronary heart disease. Eur J Clin Invest 1994;24:724-32.
14. Schuff-Werner P. Long-run outcome of patients treated with HELP apheresis. Abstracts from 6th HELP Meeting February 2003 Bad Oeynhausen.
15. Mellwig KP, Baller D, Gleichmann U et al. Improvement of coronary vasodilation capacity through single LDL apheresis. Atherosclerosis 1998;139:173-8.
16. Mellwig KP. Myocardial perfusion in HELP apheresis objectified by PET. Abstracts from 6th HELP Meeting February 2003 Bad Oeynhausen.
17. Jaeger BR, Meiser B, Nagel D et al. Aggressive lowering of fibrinogen and cholesterol in the prevention of graft vessel disease after heart transplantation. Circulation 1997;96 (Suppl. II):154-8.
18. Jaeger BR. Bengel F, Odaka K et al. Der akute Einfluβ der HELP. -Apherese auf den myokardialen Blutfluβ bei herztransplantierten Patienten. Z Kardiol 2000;4:83.
19. Park JW, Merz M, Braun P. regression of transplant coronary artery disease during chronic low-density lipoprotein apheresis. J Heart Lung Transplant 1997;16:290-7.
20. Jaeger BR, Braun P, Nagel D et al. A combined treatment of statins and HELP apheresis for treatment of cardiac allograft vasculopathy. Atherosclerosis 2002;141:331-6.
21. Mellwig KP, Moll D, Baller D, Holzinger J, Horstkotte D. Influence of LDL apheresis on coronary vasodilation capacity in patients suffering from coronary artery disease with increased lipoprotein (a) levels and low LDL cholesterol. Eur Heart J 2000;21:495.
22. Jaeger BR, Oberhoffer M, Kreuzer E, Überfuhr P, Reichart B, Seidel D. Postoperative lowering of fibrinogen for the prevention of early graft closure after CABG. Atherosclerosis 2002;140:157.
23. Jaeger BR, Kreuzer E, Knez A et al. Case reports on emergency treatment of cardiovascular syndromes through Heparin mediated Low density lipoprotein/fibrinogen precipitation: a new approach to augment cerebral and myocardial salvage. Ther Apher 2002;6:394-8.
24. Pfefferkorn TK, Knüppel T, Jaeger BR, Thiery J, Hamann G. Increased CO2-reactivity after Heparin-mediated Extracorporeal LDL Precipitation in patients with coronary heart disease and hypercholesterolemia. Stroke 1999;30:1802-6.
25. Walzl M, Lechner H, Walzl B, Schied G. Improved recovery of cerebral infarctions after plasmapheretic reduction of lipids and fibrinogen. Stroke 1993;24:1447-51.
26. Suckfüll M, Wimmer C, Jaeger B, Schorn K, Thiery J. Heparin-induced extracorporeal low-density lipoprotein precipitation (HELP) to improve the recovery of hearing in patients with sudden idiopathic hearing loss. Eur Arch Otorhinolaryngol 2000;257:59-61.
27. Suckfüll M and the Hearing Loss Study Group. Fibrinogen and LDL apheresis in treatment of sudden hearing loss: a randomized multicentre trial. Lancet 2002;360:1811-7.
28. Labarrere CA, Faulk WP. Fetal stem vessel endothelial changes in placentae from normal and abnormal pregnancies. Am J Reprod Immunol 1992;27/3-4:97-100.