The conflicting roles of clinicians versus investigators in HIV randomised clinical trials

Culture, Health and Sexuality

Volumn 3, Issue 1, 2001, Pages 67-79

  Hales, Gillian ^a   Beveridge, Alexander ^b   Smith, Don ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b Wales Hospital   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0042797569     PISSN: 13691058     EISSN: 14645351     Source Type: Journal    
DOI: 10.1080/136910501750035680     Document Type: Article

References (25)

1. Arras J. (1990) Noncompliance in AIDS research. Hastings Center Report, 5, 24-32.
2. Anonymous (1990) Controversy grows over parallel track for expérimental AIDS drug. New York State Journal of Medicine, March, 169.
3. Churchill, L. R. (1980) Physician-investigator/patient-subject exploring the logic and the tension. Journal of Medical Philosophy, 5, 215-224.
4. Chalmers, T. C. (1990) The need for early randomization in the development of new drugs for AIDS. Journal of the Acquired Immune Deficiency Syndromes, 3, S10-S15.
5. Dreyfus, J. F., Cremniter, D. and Guelfi, J. D. (1989) Reflections on FDA and WHO recommendations concerning clinical trials. Psychiatry &Psychobiology, 4, 117-122.
6. Gilmore, N. (1991) The impact of AIDS on drug availability and accessibility. AIDS, 5, S253-S262.
7. Glaser, B.G. and Strauss, A. L. (1967) The Discovery of Grounded Theory (New York: Aldine De Gruyter).
8. Grimshaw, J. (1990) Clinical trials: patient perspective’s. AIDS, 4, S207-S208.
9. Hart, J. T. (1993) Recruitment to randomized controlled trials. Lancet, 341, 15-39.
10. Hunter, C. P., Frelick, R. W., Feldman, A. R., Bavier, A. R., Dunlap, W. H., Ford, L., Hensen, D., Macfar-lane, D., Smart, C. R., Yancik, R. and Yates, J. W. (1987) Selection factors in clinical trials: results from the Community Clinical Oncology Program physician’s patient log. Cancer Treatment Reports, 71, 559-565.
11. Lally, J. J. and Barber, B. (1974) ‘The Compassionate Physician’: Frequency and social determinants of physician-investigator concern for human subjects. Social Forces, 53, 289-296.
12. Mackillop, W. J. and Johnston, P. A. (1986) Ethical problems in clinical research: the need for empirical studies of the clinical trial process. Journal ofChronic Disease, 39, 177-188.
13. Marshall, E. (1989) Quick release of AIDS drugs. Science, 245, 345-347.
14. Martyn, C. (1996) Not quite as random as I pretended. Lancet, 347, 70.
15. Pringle, M. and Churchill, R. (1995) Randomized controlled trial in General Practice. British Medical Journal, 311, 382-1383.
16. Richman, D. D. (1988) Public access to experimental drug therapy: AIDS raises yet another conflict between freedom of the individual and the welfare of the individual and the public. Journal of Infectious Diseases, 159, 412-415.
17. Shimm, D. S. and Speece, R. G. (1991) Industry reimbursement for entering patients into clinical trials: legal and ethical issues. Annals of Internal Medicine, 115, 148-151.
18. Spiers, H. R. (1991) Community Consultation and AIDS clinical trials, Part 1. IRB 7-10, May-June, 13, 7-11.
19. Spiro, H. M. (1975) Constraint and consent: on being a patient and a subject. New England Journal of Medicine, 293, 1134-1135.
20. Stolley, P. D. and Lasky, T. (1992) Shortcuts in drug evaluation. Clinical Pharmacology & Therapeutics, 52, 1-3.
21. Stone, J. M., Laidlaw, C. R., Page, F. J. and Cooper, I. (1994) Selection of patients for randomized trials: a study based on the MACOP-B vs CHOP in NHL study. Australian New Zealand Journal of Medicine, 24, 536-540.
22. Taylor, K. M., Margolese, R. G. and Soskoline, C. L. (1984) Physicians’ reasons for not entering eligible patients in a randomized clinical trial of surgery for breast cancer. New England Journal of Medi-cine, 310, 1363-1367.
23. Taylor, K. M. (1985) The doctor’s dilemma: physician participation in randomized clinical trials. Cancer Treatment Reports, 69, 1095-1097.
24. Taylor, K. M. (1992) Integrating conflicting professional roles: Physician participation in randomized clinical trials. Social Science and Medicine, 35, 217-224.
25. Vanderpool, H. Y., Weiss, G. B. and Ho, M. (1987) False data and last hopes: enrolling ineligible patients in clinical trials. Hastings Center Report, 17, 16-19.