Protection of ebselen on liver damage induced by CCL4 and lipopolysaccharides + D-galactosamine in vivo and in vitro

Yaoxue Xuebao

Volumn 34, Issue 2, 1999, Pages 99-102

  Tan, Yexiong ^a   Li, Wanhai ^a   Yao, Zhenzhen ^a   Jiang, Yuanying ^a   Wan, Xingwang ^a   Huang, Mao ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Ebselen; Lipid peroxidation; Liver damage

Indexed keywords

EID: 0042729683     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Muller A, Cadenas E, Graf P, et al. A novel biologically active seleno-organic compound-I. Glutathione peroxidase-like activity in vitro and antioxidant capacity of PZ51(Ebselen). Biochem Pharmacol, 1984, 33:3235
2. Hayashi, Slater TF. Inhibitory effects of ebselen on lipid peroxidation in rat liver microsomes. Free Rad Res Comm, 1986, 2:179
3. Muller A, Gabriel H, Sies H. A novel biologically active selenoorganic compound-IV. Protective glutathione-dependent effect of PZ51 (ebselen) against ADP-Fe induced lipid peroxidation in isolated hepatocytes. Biochem Pharmacol, 1985, 34:1185
4. Pritosos CR, Sokoloff M, Gustafson DL. PZ-51 (ebselen) in vivo protection against adriamycin-induced mouse cardiac and hepatic lipid peroxidation and toxicity. Biochem Pharmacol, 1992, 44:839
5. Oshita M, Takei Y, Kawano S, et al. Protective effect of ebselen on constrictive hepatic vasculature: Prevention of alcohol-induced effects on portal pressure in perfused livers. J Pharmacol Exp Ther, 1994, 271:20
6. Hu ZL, Zhang JP, Yu XB, et al. Effect of matrine on lipopolysaccharides/D-galactosamine-induced hepatitis and tumor necrosis factor release from macrophages in vitro. Acta Pharmacol Sin, 1996, 17:350
7. Johnston DE, Kroening C. Stimulation of prostaglandin synthesis in cultured liver cells. Hepatology, 1996, 24: 677
8. Seglen PO. Preparation of rat liver cells. Exp Cell Res, 1972, 74:450
9. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem, 1979, 95:351
10. Wendel A. Biochemical pharmacology of inflammatory liver injury in mice. Methods Enzymol, 1990, 186:675
11. Sies H. Ebselen: A glutathione peroxidase mimic. Oxygen radicals in biological system. Methods Enzymol, 1994, 234:476
12. Tan YX, Li WH, Tao XB, et al. Protection of ebselen against anoxic damage of cultured neurons of cerebral cortex. Acta Pharmacol Sin, 1997, 18:201