The design of trials comparing sentinel-node surgery and axillary resection

New England Journal of Medicine

Volumn 349, Issue 6, 2003, Pages 603-605

  Krag, David ^a   Ashikaga, Takamaru ^a  

^a UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AXILLARY LYMPH NODE; BIOSTATISTICS; BREAST CANCER; CANCER RESEARCH; CANCER SURGERY; CANCER SURVIVAL; CLINICAL RESEARCH; CLINICAL TRIAL; EDITORIAL; FOLLOW UP; HUMAN; LYMPH NODE DISSECTION; MEDICAL DECISION MAKING; METASTASIS; METHODOLOGY; PRIORITY JOURNAL; RANDOMIZATION; SENTINEL LYMPH NODE BIOPSY; SURVIVAL; BREAST TUMOR; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; LYMPH NODE; LYMPH NODE METASTASIS; LYMPHADENECTOMY; MORTALITY; MULTICENTER STUDY; NOTE; PATHOLOGY; RANDOMIZED CONTROLLED TRIAL; STATISTICAL ANALYSIS;

BREAST NEOPLASMS; DATA INTERPRETATION, STATISTICAL; HUMANS; LYMPH NODE EXCISION; LYMPH NODES; LYMPHATIC METASTASIS; MULTICENTER STUDIES; RANDOMIZED CONTROLLED TRIALS; RESEARCH DESIGN; SENTINEL LYMPH NODE BIOPSY; SURVIVAL ANALYSIS;

EID: 0042709578     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJMe038105     Document Type: Editorial

References (8)

1. Cabanas RM. An approach for the treatment of penile carcinoma. Cancer 1977;39:456-66.
2. Morton DL, Wen DR, Wong JH, et al. Technical details of intraoperative lymphatic mapping for early stage melanoma. Arch Surg 1992;127:392-9.
3. Krag DN, Weaver DL, Alex JC, Fairbank JT. Surgical resection and radiolocalization of the sentinel lymph node in breast cancer using a gamma probe. Surg Oncol 1993;2;335-40.
4. Giuliano AE, Kirgan DM, Guenther JM, Morton DL. Lymphatic mapping and sentinel lymphadenectomy for breast cancer. Ann Surg 1994;220:391-401.
5. Orr RK. The impact of prophylactic axillary node dissection on breast cancer survival - a Bayesian meta-analysis. Ann Surg Oncol 1999;6:109-16.
6. Krag DN, Julian T. Expert perspectives: update on NSABP-32, a randomized phase III clinical trial to compare sentinel node resection to conventional axillary dissection for clinically node-negative breast cancer. Breast Dis Year Book Q 2002;13:113-4.
7. Breast study announcements. Durham, N.C.: American College of Surgeons Oncology Group, 2003. (Accessed July 18, 2003, at www.acosog.org/studies/organ-site/breast/.)
8. Veronesi U, Paganelli G, Viale G, et al. A randomized comparison of sentinel-node biopsywith routine axillary dissection in breast cancer. N Engl J Med 2003;349:546-53.