Cost implications of administering intravenous proton pump inhibitors to all patients presenting to the emergency department with peptic ulcer bleeding

Value in Health

Volumn 6, Issue 4, 2003, Pages 457-465

  Gagnon, Yves M ^a   Levy, Adrian R ^a,b,c   Eloubeidi, Mohamad A ^d   Arguedas, Miguel R ^d   Rioux, Kevin P ^b   Enns, Robert A ^b  

^a Occam Research and Consulting Inc   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c ST PAUL S HOSPITAL   (Canada)

^d University of Alabama at Birmingham   (United States)

Author keywords

Cost analysis; Gastrointestinal bleeding; Monte Carlo simulations; Peptic ulcers; Probabilistic sensitivity analysis; Proton pump inhibitors

Indexed keywords

PROTON PUMP INHIBITOR;

ARTICLE; COMPARATIVE STUDY; COST BENEFIT ANALYSIS; DRUG COST; DRUG UTILIZATION; EMERGENCY WARD; ENDOSCOPIC THERAPY; HEALTH CARE COST; HEALTH CARE UTILIZATION; HUMAN; MEDICAL DECISION MAKING; MEDICARE; MONTE CARLO METHOD; PEPTIC ULCER BLEEDING; PRIORITY JOURNAL; STATISTICAL ANALYSIS; TREATMENT OUTCOME; UPPER GASTROINTESTINAL BLEEDING;

EID: 0042709537     PISSN: 10983015     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1524-4733.2003.64262.x     Document Type: Article

References (45)

1. Barkun AN, Cockeram AW, Plourde V, Fedorak RN. Review article: acid suppression in nonvariceal acute upper gastrointestinal bleeding. Aliment Pharmacol Ther 1999;13:1565-84.
2. Gisbert JP, Gonzalez L, Clavet X, et al. Proton pump inhibitors versus H2-antagonists: a metaanalysis of their efficacy in treating bleeding peptic ulcer. Aliment Pharmacol Ther 2001;15:917-26.
3. Yacyshyn BR, Thomson AB. Critical review of acid suppression in nonvariceal acute upper gastrointestinal bleeding. Dig Dis 2000;18:117-28.
4. Huang JQ, Hunt RH. Pharmacological and pharmacodynamic essentials of H(2)-receptor antagonists and proton pump inhibitors for the practicing physician. Best Pract Res Clin Gastroenterol 2001; 15:355-70.
5. Lau JYW, Sung JJY, Lee KKC, et al. Effect of intravenous omeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers. N Engl J Med 2000;343:310-6.
6. Schaffalitzky de Muckadell OB, Havelund T, Harling H, et al. Effect of omeprazole on the outcome of endoscopically treated bleeding peptic ulcers: randomized double-blind placebo-controlled multicenter study. Scand J Gastroenterol 1997;32:320-7.
7. Hasselgren G, Lind T, Lundell L, et al. Continuous intravenous infusion of omeprazole in elderly patients with peptic ulcer bleeding. Scand J Gastroenterol 1997;32:328-33.
8. Spiegel BMR, Vakil NB, Ofman JJ. Endoscopy for acute nonvariceal upper gastrointestinal tract hemorrhage: is sooner better? Arch Intern Med 2001;161:1393-404.
9. Cooper GS, Chark A, Connors AF, et al. The effectiveness of early endoscopy for upper gastrointestinal hemorrhage. Med Care 1998;36:462-74.
10. Hay JA, Maldonado L, Weingarten SR, Ellrodt G. Prospective evaluation of a clinical guideline recommending hospital length of stay in upper gastrointestinal tract hemorrhage. JAMA 1997;278:2151-6.
11. Chan LY, Sung JJ. Review article: the role of pharmaco-therapy for acute variceal haemorrhage in the era of endoscopic hemostasis. Aliment Pharmacol Ther 1997;11:45-50.
12. Sivri B, Oksuzoglu G, Bayraktar Y, Kayhan B. A prospective randomized trial from Turkey comparing octreotide versus injection sclerotherapy in acute variceal bleeding. Hepatogastroenterology 2000;47:168-73.
13. Somerville K, Faulkner G, Langman M. Nonsteroidal anti-inflammatory drugs and bleeding peptic ulcer. Lancet 1986;1:462-4.
14. Griffin MR, Ray WA, Schaffner W. Nonsteroidal anti-inflammatory drug use and death from peptic ulcer in elderly persons. Ann Intern Med 1988;109:359-63.
15. Griffin MR, Piper JM, Daugherty JR, et al. Nonsteroidal anti-inflammatory drug use and increased risk for peptic ulcer disease in elderly persons. Ann Intern Med 1991;114:257-63.
16. Carson JL, Strom BL, Soper KA, et al. The association of nonsteroidal anti-inflammatory drugs with upper gastrointestinal tract bleeding. Arch Intern Med 1987;147:85-8.
17. Bloom BS. Risk and cost of gastrointestinal side effects associated with nonsteroidal anti-inflammatory drugs. Arch Intern Med 1989;149:1019-22.
18. Gabriel SE, Jaakimainen L, Bombardier C. Risk for serious gastrointestinal complications related to use of nonsteroidal anti-inflammatory drugs: a meta-analysis. Ann Intern Med 1991;115:787-96.
19. Laine L. Nonsteroidal anti-inflammatory drug gastropathy. Gastrointest Endosc Clin N Am 1996;6:489-504.
20. Laine L, Peterson WL. Bleeding peptic ulcer. N Engl J Med 1994;331:717-27.
21. Jensen DM. Clots and spots on ulcer: why and how to treat. Langenbecks Arch Surg 2001;386:82-7.
22. Lin HJ, Lee FY, Kang WM, et al. A controlled study of therapeutic endoscopy for peptic ulcer with non-bleeding visible vessel. Gastrointest Endosc 1990;36:241-6.
23. Cook DJ, Guyatt GH, Salena BJ, Laine LA. Endoscopic therapy for acute nonvariceal upper gastrointestinal hemorrhage: a meta-analysis. Gastroenterology 1992;102:139-48.
24. Laine L. Multipolar electrocoagulation in the treatment of active upper gastrointestinal tract hemorrhage: a prospective controlled trial. N Engl J Med 1987;316:1613-7.
25. Petersen WL. Therapeutic endocospy and bleeding ulcers: clinical risk factors. Gastrointest Endosc 1990;36:S14-5.
26. Petersen WL. Therapeutic endoscopy and bleeding ulcers: efficacy criteria - outcome of therapy. Gastrointest Endosc 1990;36:S23-4.
27. Fullarton GM, Birnie GG, MacDonald A, Murray WR. The effect of introducing endoscopic therapy on surgery and mortality rates for peptic ulcer hemorrhage: a single center analysis of 1,125 cases. Endoscopy 1990;22:110-3.
28. Macchiado GA, Jensen DM. Thermal probe alone or with epinephrine for the endoscopic haemostasis of ulcer haemorrhage. Baillieres Best Pract Res Clin Gastroenterol 2000;14:443-58.
29. Savides TJ, Jensen DM. Therapeutic endoscopy for nonvariceal gastrointestinal bleeding. Gastroenterol Clin North Am 2000;29:465-87.
30. Ofman J, Wallace J, Badamgarav E, et al. The cost-effectiveness of competing strategies for the prevention of recurrent peptic ulcer hemorrhage. Am J Gastroenterol 2002;97:1941-50.
31. Phelps C, Mushlin A. Focusing technology assessment using medical decision theory. Med Decis Making 1988;8:279-89.
32. Drummond MF, O'Brien B, Stoddart GL, Torrance GW. Methods for the Economic Evaluation of Health Programmes (2nd ed.). Oxford: Oxford University Press, 1997.
33. Lau JY, Sung JJ, Lam YH, et al. Endoscopic retreatment compared with surgery in patients with recurrent bleeding after initial endoscopic control of bleeding ulcers. N Engl J Med 1999;340: 751-6.
34. Stabile BE, Stamos MJ. Therapy of high-risk bleeding: surgical management of gastrointestinal bleeding. Gastroenterol Clin North Am 2000;29:189-222.
35. Martin RM, Dunn NR, Freemantle S, Shakir S. The rates of common adverse events reported during treatment with proton pump inhibitors used in general practice in England: cohort studies. Br J Clin Pharmacol 2000;50:366-72.
36. Federal Register [Internet]. Baltimore (MD): Community of Science, Inc., c2003 [accessed November 15, 2002]. Available from: http://fr.cos.com/
37. Krahn MD, Naglie G, Naimark D, et al. Primer on medical decision analysis. Part 4. Analyzing the model and interpreting the results. Med Decis Making 1997;17:142-51.
38. Doubilet P, Begg CB, Weinstein MC, et al. Probabilistic sensitivity analysis using Monte Carlo simulation. Med Decis Making 1985;5:157-77.
39. Critchfield GC, Willard KE. Probabilistic sensitivity analysis of decision trees using Monte Carlo simulation. Med Decis Making 1986;6:85-92.
40. Critchfield GC, Willard KE, Connelly DP. Probabilistic sensitivity analysis methods for general decision models. Comput Biomed Res 1986;19: 254-65.
41. Briggs AH. Handling uncertainty in cost-effectiveness models. Pharmacoeconomics 2000; 17:479-500.
42. Briggs AH, O'Brien BJ, Blackhouse G. Thinking outside the box: recent advances in the analysis and presentation of uncertainty in cost-effectiveness studies. Annu Rev Pub Health 2002;23:377-401.
43. Green FW Jr, Kaplan MM, Curtis LE, Levine PH. Effect of acid and pepsin on blood coagulation and platelet aggregation: a possible contributor prolonged gastroduodenal mucosal hemorrhage. Gastroenterology 1978;74:38-43.
44. Berstad A. Does profound acid inhibition improve haemostasis in peptic ulcer bleeding? Scand J Gastroenterol 1997;32:396-82.
45. Rockall TA, Logan RF, Devlin HB, Northfield TC. Risk assessment after acute upper gastrointestinal haemorrhage. Gut 1996;38:316-21.