Invited review microcirculation and Chagas' disease: Hypothesis and recent results

Revista do Instituto de Medicina Tropical de Sao Paulo

Volumn 41, Issue 2, 1999, Pages 123-129

  Ramos, Simone G ^a   Rossi, Marcos A ^b  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b NONE

Author keywords

Cardiopathy; Chagas' disease; Microcirculation; Review

Indexed keywords

ANIMAL; CHAGAS DISEASE; DOG; HUMAN; MICROCIRCULATION; MOUSE; PATHOPHYSIOLOGY; RAT; REVIEW;

ANIMALS; CHAGAS CARDIOMYOPATHY; DOGS; HUMANS; MICE; MICROCIRCULATION; RATS;

EID: 0042706732     PISSN: 00364665     EISSN: None     Source Type: Journal    
DOI: 10.1590/S0036-46651999000200011     Document Type: Article

References (70)

1. ALENCAR, A.; DE KARSTEN, M.R.Q. & CERQUEIRA, M.C. - Estudo do sistema nervoso autônomo do aparelho digestive em camundongos albinos cronicamente infectados pelo Schizotrypanum cruzi. Hospital (Rio de J.), 73: 165-176, 1968.
2. ALVARENGA, R.L. - Histopatologia da moléstia de Chagas e do calazar em cães naturalmente infectados. Hospital (Rio de J.), 57: 23-40, 1960.
3. ANDRADE, Z.A. & ANDRADE, S.G. - A patogenia da miocardite crônica chagásica. Arq. bras. Med., 6: 1-53, 1955.
4. ANDRADE, Z.A. - Anatomia patológica da moléstia de Chagas. Rev. goiana Med., 4: 103-119, 1958.
5. ANDRADE, Z.A. - Anatomia patológica. In: CANÇADO R., ed. Doença de Chagas. Belo Horizonte, Fundação Carlos Chagas, 1968. p.315-343.
6. ANDRADE, Z.A.; ANDRADE, S.G.; CORREA R.; SADIGURSKY, M. & FERRANS, V.J. - Myocardial changes in acute Trypanosoma cruzi infection. Ultrastructural evidence of immune damage and the role of microangiopathy. Amer. J. Path., 144: 1403-1411, 1994.
7. BESTETTI, R.B. & ROSSI, M.A. - A rationale approach for mortality risk stratification in Chagas' heart disease. Int. J. Cardiol., 58: 199-209, 1997.
8. BEVILACQUA M.P.; POBER. J.S.; MAJEAU, G.R.; COTRAN, R.S. & GIMBRONE JR., M.A. - Interleukin 1 (IL-1) induces biosynthesis and cell surface expression of procoagulant activity in human vascular endothelial cells. J. exp. Med., 160: 618-623, 1984.
9. BONADONNA, G.; LECHI, C.; CORRADINI, P. et al. - Verapamil inhibits platelet aggregation by a calcium independent mechanism. Thromb. Haemost., 56: 308-310, 1986.
10. BRENER, Z. - Biology of Trypanosoma cruzi. Ann. Rev. Microbiol., 27: 347-382, 1973.
11. BRITO, T. - Miocardite alérglca do cobaio e sua possível relação com a cardite chagásica experimental. São Paulo, 1962. (Tese de Doutoramento - Universidade de São Paulo).
12. BRITO, T. & VASCONCELOS, E. - Necrotizing arteritis in megaesophagus. Histopathology of ninety-one biopsies taken from the cardia. Rev. Inst. Med. trop. S. Paulo, 1: 195-206, 1959.
13. CASTRO, R.; KUSCHNIR, E. & SGAMMINI, H. - Evaluacion de la performance cardiaca y perfusion miocardica con radiotrazadores en la cardiopatia chagasica cronica. Rev. Fed. argent. Cardiol., 17: 226-231, 1988.
14. CHAGAS, C. - Nova tripanozomiase humana: estudos sob a morfologia e o ciclo evolutivo do Schizotrypanum cruzi n. gen., s. sp. agente etiológico de nova entidade mórbida no homem. Mem. Inst. Oswaldo Cruz, 1: 159-218, 1909.
15. CHAPADEIRO, E. - Sobre as lesões vasculares da cardiopatia chagásica crônica. Hospital (Rio de J.), 67: 1027-1029, 1965.
16. COELHO, N.A. - Aspecto anatomopatológico do coraçáo na moléstia de Chagas. Rev. Med. Cirurg. S.Paulo, 4: 209-211, 1944.
17. COUCEIRO, A. - Lesões do ciático na infecção experimental de cães pelo Schizotrypanum cruzi (nota prévia). Mem. Inst. Oswaldo Cruz, 39: 435-439, 1943.
18. FACTOR, S.M. & SONNENBLICK, E.H. - Hypothesis: is congestive cardiomyopathy caused by a hyperreactive myocardial microcirculation (microvascular spasm)? Amer. J. Cardiol., 50: 1149-1152, 1982.
19. FACTOR, S.M.; CHO, S.; WITTNER, M. & TANOWITZ, H.B. - Abnormalities of the coronary microcirculation in acute murine Chagas' disease. Amer. J. trop. Med. Hyg., 34: 246-253, 1985.
20. FACTOR, S.M.; MINASE, T.; BHAN, R.; WOLINSKY, H. & SONNENBLICK, E.H. - Hypertensive diabetic cardiomyopathy in the rat: ultrastructural features. Virchows Arch. path. Anat., 398: 305-317, 1983.
21. FERRANS, V.J.; MILEI, J.; TOMITA, Y. & STORINO, R.A. - Basement membrane thickening in cardiac myocytes and capillaries in chronic Chagas' disease. Amer. J. Cardiol., 61: 1137-1140, 1988.
22. FERREIRA, C.S.; LOPES, E.R.; CHAPADEIRO, E. et al. - Coronariografia post mortem na cardite chagásica crônica: correlação anátomo-radiológica. Arq. bras. Cardiol., 34: 81-86, 1980.
23. HAGAR, J.M.; TUBAU, J.F. & RAHIMTOOLA, S.H. - Chagas' heart disease in the USA: Thallium abnormalities mimic coronary artery disease. Circulation, 84 (suppl. II): 631, 1991.
24. HIGUCHI, M.L.; BRITO, T.; PARZIANELLO, L.C.; FUKASAWA, S. & RAMIRES, J.A. - Severe arteriolar dilatation and ischemic lesions in chronic Chagas' cardiopathy: a 3D confocal laser microscopic study. J. Amer. Coll. Cardiol., 31: 3 33, 1998.
25. JÖRG, M.E. - Tripanosomiasis cruzi; anarquía angiotopográfica por descapilarización mesenquimorreactiva: cofactor patogénico de la miocardiopatia crónica. Pren. méd. argent., 61: 94-106, 1974.
26. JÖRG, M.E. - Reactividad de endotelios vasculares frente a antigenos del Trypanosoma cruzi. CM Publ. cient. (Mar del Plata), 4: 134-143, 1991.
27. KÖBERLE, F. - Cardiopatia chagásica. Hospital (Rio de J.), 53: 311-346, 1958.
28. KÖBERLE, F. - Chagas' disease and Chagas' syndromes: the pathology of American trypanosomiasis. Advanc. Parasit., 6: 63-116, 1968.
29. KÖBERLE, F.; OLIVEIRA, J.S.M. & MELLO DE OLIVEIRA, J.A. - "Research report of chronic Chagas' cardiopathy". In: W.H.O. Meeting on Cardiopathies. Nova Dehli, 1966.
30. KUSCHNIR. E.; KUSTICH, F.; EPELMAN, M.; SANTAMARINA, N. & PODIO, R.B. - Valoración del flujo miocárdico con Rb 86, en pacientes con cardiopatia chagasica, con insuficiencia coronaria y en controles normales. Parte 1: estudios basales. Arq. bras. Cardiol., 27: 187-196, 1974.
31. KUSCHNIR, E.; EPELMAN, M.; KUSTICH, F.; SANTAMARINA, N. & PODIO, R.B. - Valoración del flujo miocárdico con Rb 86, en pacientes con cardiopatia chagasica, con insuficiencia coronaria y en controles normales. Parte 2: respuesta al ejercicio y la cardiotonificación aguda. Arq. bras. Cardiol., 27: 721-732, 1974.
32. LARANJA. F.S.; DIAS, E.; NÓBREGA, C. & MIRANDA, A. - Chagas' disease: a clinical, epidemiological, and pathological study. Circulation, 14: 1035-1060, 1956.
33. LIBBY, P.; ALROY, J. & PEREIRA, M.E.A. - A neuraminidase from Trypanosoma cruzi removes sialic acid from the surface of mammalian myocardial and endothelial cells. J. clin. Invest., 77: 127-135, 1986.
34. LUCENA, D.T.; CARVALHO, J.A.M.; ABATH. E.C. & AMORIM, N. - Terapêutica experimental da doença de Chagas. I. Ação de uma 8-aminoquinoleina em ratos albinos. Hospital (Rio de J.), 62: 1278-1296, 1962.
35. MACCLURE, E. & POCHE, R. - Microscopia eletrônica da miocardite chagásica experimental em camundongos albinos. In: INTERNATIONAL CONGRESS IN TROPICAL MEDICINE AND MALARIA, 2., Rio de Janeiro, 1963. p. 249-250.
36. MANTOVANI, A. & DEJANA, E. - Cytokines as communication signals between leukocytes and endothelial cells. Immunol. today, 10: 370-375, 1989.
37. MARIN NETO, J.A.; MARZULLO, P.; PINTYA, A.O. et al. - Myocardial perfusion disturbances detected by 99m-Tc-microspheres in Chagas' patients with angiographically normal coronary arteries (Abstract). Europ. Heart J., 15(suppl.): 362, 1994.
38. MARIN NETO, J.A.; MARZULLO, P.; MARCASSA, C. et al. - Myocardial perfusion abnormalities in chronic Chagas' disease as detected by Thallium-201 scintigraphy. Amer. J. Cardiol., 69: 780-784, 1992.
39. MAZZA, S. & BENITEZ, C. - Comprobación de la natureza esquizotripanósíca y frecuencia de la dacrioretinitis en la enfermedad de Chagas. M.E.P.R.A. (Misión de Estudios de Patología Regional Argentina), 31: 3-31, 1937.
40. MAZZA, S.; BASSO, G. & JÖRG. M.E. - Primer caso mortal de forma cronica cardiaca de enfermedad de Chagas comprobado en Mendoza. M.E.P.R.A. (Misión de Estudios de Patología Regional Argentina), 42: 3-73, 1939.
41. MORRIS, S.A.; TANOWITZ, H.B.; WITTNER, M. & BILEZIKIAN, J.P. Pathophysiological insights into the cardiomyopathy of Chagas' disease. Circulation, 82: 1900-1909, 1990.
42. MORRIS, S.A.; TANOWITZ, H.B.; HATCHER, V.; BILEZIKIAN, J.P. & WITTNER, M. - Alterations in intracellular calcium following infection of human endothelial cells with Trypanosoma cruzi. Molec. Biochem. Parasit., 29: 213-221, 1988.
43. MORRIS, S.A.; TANOWITZ, H.B.; MAKMAN, M. et al. - Trypanosoma cruzi: alteration of cAMP metabolism following infection of human endothelial cells. Exp. Parasit., 74: 69-76, 1992.
44. MORRIS, S.A.; WEISS, L.M.; FACTOR, S.M. et al - Verapamil ameliorates clinical, pathological and biochemical manifestations of experimental chagasic cardiomyopathy in mice. J. Amer. Coll. Cardiol., 14: 782-789, 1989.
45. NACHMAN, R.L.; HAJJAR, K.A.; SILVERSTEIN, R.L. & DINARELLO, C.A. - Interleukin 1 induces endothelial cell synthesis of plasminogen activator inhibitor. J. exp. Med., 163: 1595-1600, 1986.
46. OKUMURA, M.; SILVA, A.C. & CORREA NETO, A. - Contribuição para o estudo da patogenia das lesões vasculares na doença de Chagas experimental em camundongos brancos. Rev. paul. Med., 61: 265-266, 1962.
47. OKUMURA, M.; BRITO, T.; PEREIRA-DA-SlLVA, L.H.; CARVALHO-DA-SILVA, A. & CORREA-NETO, A. - The pathology of experimental Chagas' disease in mice. I. Digestive tract changes with special reference to necrotizing arteritis. Rev. Inst. Med. trop. S. Paulo, 2: 17-28, 1960.
48. OLIVEIRA, J.S.M.; MONTEIRO DOS SANTOS, J.C.; MUCCILLO, G. & FERREIRA, A.L. - Increased capacity of the coronary arteries in chronic Chagas' heart disease: further support for the neurogenic pathogenesis concept. Amer. Heart J., 109: 304-308, 1985.
49. RAMOS JR., J. & TIBIRIÇÁ, P.Q.T. - Miocardite crônica na moléstia de Chagas. Rev. bras. Med., 2: 1-9, 1945.
50. ROSSI, M.A. - Microvascular changes as a cause of chronic cardiomyopathy in Chagas' disease. Amer. Heart J., 120: 233-236, 1990.
51. ROSSI. M.A. - Aortic endothelial cell changes in the acute septicemic phase of experimental Trypanosoma cruzi infection in rats: scanning and transmission electron microscopy study. Amer. J. trop. Med. Hyg., 57: 321-327, 1997.
52. ROSSI, M.A. - Fibrosis and inflammatory cells in human chronic chagasic myocarditis: scanning electron microscopy and immunohistochemical observations. Int. J. Cardiol., 66: 183-194, 1998.
53. ROSSI, M.A. & BESTETTI, R.B. - The challenge of chagasic cardiomyopathy: the pathologic roles of autonomic abnormalities, autoimmune mechanisms and microvascular changes, and therapeutic implications. Cardiology, 86: 1-7, 1995.
54. ROSSI, M.A. & CAROBREZ, S.G. - Experimental Trypanosoma cruzi cardiomyopathy in BALB/c mice: histochemical evidence of hypoxic changes in the myocardium. Brit. J. exp. Path., 66: 155-160, 1985.
55. ROSSI, M.A.; GONÇALVES, S. & RIBEIRO-DOS-SANTOS, R. - Experimental Trypanosoma cruzi cardiomyopathy in BALB/c mice. The potential role of intravascular platelet aggregation in its genesis. Amer. J. Path., 114: 209-216, 1984.
56. REZKALLA, S.; KLONER, R.A.; KHATIB, G. & KHATIB, R. - Effect of delayed captopril therapy on left ventricular mass and myonecrosis during acute coxsackievirus murine myocarditis. Amer. Heart J., 120: 1377-1381, 1990.
57. SCHELLING, P.; FISCHER, H. & GANTEN, D. - Angiotensin and cell growth: a link to cardiovascular hypertrophy? J. Hypertens., 9: 3-15, 1991.
58. TANOWITZ, H.B.; KAUL, D.K.; CHEN, B. et al. - Compromised microcirculation in acute murine Trypanosoma cruzi infection. J. Parasit., 82: 124-130, 1996.
59. TANOWITZ, H.B.; BURNS. E.R.; SINHA, K.A. et al. - Enhanced platelet adherence and aggregation in Chagas' disease: a potential pathogenic mechanism for cardiomyopathy. Amer. J. trap. Med. Hyg., 43: 274-281, 1990.
60. TANOWITZ, H.B.; GUMPRECHT, J.P.; SPURR, D. et al. - Cytokine gene expression of endothelial cells infected with Trypanosoma cruzi. J. Infect. Dis., 166: 598-603, 1992.
61. TORRES, CM. - Estudo do miocárdio na moléstia de Chagas (forma aguda). Mem. Inst. Oswaldo Cruz, 9: 114-139, 1917.
62. TORRES, C.M. - Sobre a anatomia patológica da doença de Chagas. Hospital (Rio de J.), 36: 391-409, 1941.
63. TORRES, C.M. - Arteriolosclerose das finas ramificações arteriais do miocárdio (coronarite chagásica) e miocitólise focal do miocárdio na cardiopatia chagásica crônica. Hospital (Rio de J.), 54: 597-610, 1958.
64. TORRES, C.M. - Miocitólise e fibrose do miocárdio na doença de Chagas. Mem. Inst. Oswaldo Cruz, 58: 161-182, 1960.
65. TORRES, F.W.; ACQUATELLA, H.; CONDADO, J.A., DINSMORE, R. & PALACIOS, I.F. - Coronary vascular reactivity is abnormal in patients with Chagas' disease. Amer. Heart J., 129: 995-1001, 1991.
66. VAN VOORHIS, W.C. - Coculture of human peripheral blood mononuclear cells with Trypanosoma cruzi leads to proliferation of lymphocytes and cytokine production. J. Immunol., 184: 239-248, 1992.
67. VIANNA, G. - Contribuição para o estudo da anatomia patológica da moléstia de Chagas. Mem. Inst. Oswaldo Cruz, 3: 276-294, 1911.
68. VIANNA, L.G.; CAMPOS, G.P. & MAGALHÃES, A.V. - Infarto do miocárdio sem obstrução coronariana associado a cardiopatia chagásica crônica. Arq. bras. Cardiol., 33: 41-47, 1979.
69. WHARTON, J.M.; COLEMAN, R.E. & STRAUSS, H.C. - The role of autonomic nervous system in sudden cardiac death. Trends Cardiovasc. Med., 2: 65-71, 1992.
70. WITTNER, M.; CHRIST, G.J.; HUANG, H. et al. - Trypanosoma cruzi induces endolthelin release from endothelial cells. J. infect. Dis., 171: 497-497, 1995.