EM574, a motilide, has an orexigenic activity with affinity for growth-hormone secretagogue receptor [2]

Journal of Gastroenterology and Hepatology (Australia)

Volumn 18, Issue 7, 2003, Pages 881-882

  Asakawa, Akihiro ^a   Inui, Akio ^a   Ohinata, Kousaku ^b   Fujimiya, Mineko ^c   Meguid, Michael M ^d   Yoshikawa, Masaaki ^b  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^d SUNY UPSTATE MEDICAL UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8,9 ANHYDRO N ISOPROPYLNORERYTHROMYCIN A 6,9 HEMIACETAL; APPETITE STIMULANT; GHRELIN; GROWTH HORMONE SECRETAGOGUE RECEPTOR;

DRUG MECHANISM; FEEDING BEHAVIOR; FOOD INTAKE; LETTER; NONHUMAN; PREDICTION; PRIORITY JOURNAL; SPECIES COMPARISON; STOMACH EMPTYING;

EID: 0042703301     PISSN: 08159319     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1746.2003.03073.x     Document Type: Letter

References (5)

1. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999; 402: 656-60.
2. Inui A. Ghrelin: an orexigenic and somatotrophic signal from the stomach. Nat. Rev. Neurosci. 2001; 2: 551-60.
3. Asakawa A, Inui A, Kaga T et al. Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin. Gastroenterology 2001; 120: 337-45.
4. Itoh Z. Motilin and clinical application. Peptides 1997; 18: 593-608.
5. Asakawa A, Inui A, Momose K, Ueno N, Fujino MA, Kasuga M. Motilin increases food intake in mice. Peptides 1998; 19: 987-90.