An efficient synthesis of ortho-N-Boc-arylmethyl ketone derivatives

Tetrahedron Letters

Volumn 44, Issue 34, 2003, Pages 6429-6432

  Broutin, Pierre Emmanuel ^a   Hilty, Peter ^a   Thomas, Andrew W ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

4 methylene 3,1 benzoaxin 2 one; ortho N Boc acetophenone; Polymer supported reagents; Protecting groups

Indexed keywords

KETONE DERIVATIVE;

ACIDITY; ARTICLE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; SYNTHESIS; THIN LAYER CHROMATOGRAPHY;

EID: 0042698454     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(03)01597-1     Document Type: Article

References (5)

1. Two other methods for the preparation of ortho-N-Boc-acetophenone have been reported: (a) Zwang, P.; Terefenko, E. A.; Slavin, J. Tetrahedron Lett. 2001, 42, 2097; (b) Chandrasekhar, S.; Narsihmulu, Ch. Tetrahedron Lett. 2000, 41, 7969.
2. Two other methods for the preparation of ortho-N-Boc-acetophenone have been reported: (a) Zwang, P.; Terefenko, E. A.; Slavin, J. Tetrahedron Lett. 2001, 42, 2097; (b) Chandrasekhar, S.; Narsihmulu, Ch. Tetrahedron Lett. 2000, 41, 7969.
3. Visser C.M., Kellogg R.M. Bioorg. Chem. 6:1977;79.
4. Molina P., Conesa C., Alias A., Arques A., Velasco M.D. Tetrahedron. 49:1993;7599.
5. Ley S.V., Baxendale I.R., Bream R.N., Jackson P.S., Leach A.G., Longbottom D.A., Nesi M., Scott J.S., Storer R.I., Taylor S.J. J. Chem. Soc., Perkin Trans. 1. 2000;3815.