Investigation into the astrocytic immunoreactivity to GFAP and vimentin in the brainstem of Wistar rats submitted to the ethidium bromide gliotoxic model;Estudo da imunorreatividade astrocitária para GFAP e vimentina no tronco encefálico de ratos Wistar submetidos ao modelo gliotóxico do brometo de etídio

Arquivos de Neuro-Psiquiatria

Volumn 61, Issue 3 A, 2003, Pages 642-649

  Bondan, Eduardo Fernandes ^a,b,e   Lallo, Maria Anete ^a,b   Dagli, Maria Lúcia Zaidan ^c   Sanchez, Melissa ^b   Graça, Dominguita Lühers ^d  

^a Universidade Bandeirante de Sao Paulo   (Brazil)

^b PAULISTA UNIVERSITY   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

^d FEDERAL UNIVERSITY OF SANTA MARIA   (Brazil)

^e NONE   (Brazil)

Author keywords

Astrocytes; CNS; Ethidium bromide; GFAP; Vimentin

Indexed keywords

ETHIDIUM BROMIDE; GLIAL FIBRILLARY ACIDIC PROTEIN; SODIUM CHLORIDE; VIMENTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; BRAIN STEM; CELL INFILTRATION; CONTROLLED STUDY; HISTOLOGY; IMMUNOCOMPETENT CELL; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MACROPHAGE; MESENCEPHALON; NONHUMAN; PONS; RAT;

EID: 0042694836     PISSN: 0004282X     EISSN: None     Source Type: Journal    
DOI: 10.1590/s0004-282x2003000400022     Document Type: Article

References (22)

1. Benveniste EN. Cytokines: influence on glial cell gene expression and function. In Blalock JE (ed). Neuroimmunoendocrinology. 2.Ed. Basel: Karger, 1992:106-153.
2. Bignami A, Dahl D. Glial cells in the central nervous system and their reaction to injury. Austin: Landes, 1994.
3. Pixley SK, de Vellis J. Transition between radial glia and mature astrocytes studied with a monoclonal antibody to vimentin. Dev Brain Res 1984;15:201-209.
4. Takamiya Y, Kohsaka S, Toya S, Otani M, Tsukuda Y. Immunohistochemical studies on the proliferation of reactive astrocytes and the expression of cytoskeletal proteins following brain injury. Dev Brain Res 1988;38:201-210.
5. Yajima K, Suzuki K. Ultrastructural changes of oligodendroglia and myelin sheats induced by ethidium bromide. Neuropathol Appl Neurobiol 1979;5:49-62.
6. Yajima K, Suzuki K. Demyelination and remyelination in the rat central nervous system following ethidium bromide injection. Lab Invest 1979;41:385-392.
7. Graça DL, Blakemore WF. Delayed remyelination in rat spinal cord following ethidium bromide injection. Neuropathol Appl Neurobiol 1986;12:593-605.
8. 3 ganglioside immunoreactivity. J Neurosci Res 1993;36:405-422.
9. Pereira LAV, Dertkigil MSJ, Graça DL, Cruz-Höfling MA. Dynamics of remyelination in the brain of adult rats after exposure to ethidium bromide. J Submicrosc Cytol Pathol 1998;30:341-348.
10. Bondan EF, Lallo MA, Sinhorini IL, Graça DL. Schwann cells may express an oligodendrocyte-like remyelinating pattern following ethidium bromide injection in the rat brainstem. Acta Microscopica 1999;8:707-708.
11. Bondan EF, Lallo MA, Sinhorini IL, Baz EI, Paulino CA, Graça DL. Ultrastructural investigation on the brainstem remyelination after local ethidium bromide injection in rats immunosuppressed with dexamethasone. Acta Microscopica 1999;8:709-710.
12. Bondan EF, Lallo MA, Sinhorini IL, Pereira LAV, Graça DL. The effect of cyclophosphamide on brainstem remyelination following ethidium bromide injection in Wistar rats. J Submicrosc Cytol Pathol 2000;32:603-612.
13. Bondan EF, Lallo MA, Dagli MLZ, Pereira LAVD, Graça DL. Ruptura da barreira hematoencefálica após injeção de droga gliotóxica no tronco encefálico de ratos Wistar. Arq Neuropsiquiatr 2002;60:582-589.
14. Hsu S-M, Raine L, Fanger H. A comparative study of the peroxidase-antiperoxidase method and an avidin-biotin complex method for studying polypeptide hormones with radioimmunoassay antibodies. Am J Clin Pathol 1981;75:734-738.
15. Kálman M, Hájos F. Distribution of glial fibrillary acidic protein (GFAP)-immunoreactive astrocytes in the rat brain. I. Forebrain. Exp Brain Res 1989;78:147-163.
16. Hájos F, Kalman M. Distribution of glial fibrillary acidic protein (GFAP)-immunoreactive astrocytes in the rat brain. II. Mesencephalon, rhombencephalon and spinal cord. Exp Brain Res 1989;78:164-173.
17. Jeffrey M, Wells GHA, Bridges AW. An immunohistochemical study of the topography and cellular localization of three neural proteins in the sheep nervous system. J Comp Pathol 1990;103:23-35.
18. Petito CK, Morgello S, Felix JC, Lesse ML. The two patterns of reactive astrocytosis in postischemic rat brain. J Cer Blood Flow Metab 1990;10:850-859.
19. Schiffer D, Giordana MT, Migheli A, Giacone G, Pezzotta S, Mauro A. Glial fibrillary acidic protein and vimentin in the experimental glial reaction of the rat brain. Brain Res 1986;374:110-118.
20. Eddleston M, Mucke L. Molecular profile of reactive astrocytes-implications for their role in neurologic disease. Neuroscience 1993;54:15-36.
21. Noremberg, MD. Astrocyte responses to CNS injury. J Neuropathol Exp Neurol 1994;53:213-220.
22. Fernaud-Espinosa I, Nietro-Sampedro M, Bovolenta P. Diffferential activation of microglia and astrocytes in aniso- and isomorphic gliotic tissue. Glia 1993;8:277-291.