Synthesis and stereochemical structure activity relationships of 1,3- dioxoperhydropyrido[1,2-c]pyrimidine derivatives: Potent and selective cholecystokinin-a receptor antagonists

Journal of Medicinal Chemistry

Volumn 40, Issue 21, 1997, Pages 3402-3407

  Martín Martínez, Mercedes ^a   Bartolomé Nebreda, José M ^a   Gómez Monterrey, Isabel ^a   González Muñiz, Rosario ^a   Garcĩa Lõpez, M Teresa ^a   Ballaz, Santiago ^b   Barber, Ana ^b   Fortuño, Ana ^b   Del Río, Joaquín ^b   Herranz, Rosario ^a  

^a INSTITUTO DE QUÍMICA MÉDICA   (Spain)

^b UNIVERSITY OF NAVARRA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2,3 DIHYDRO 1 METHYL 2 OXO 5 PHENYL 1H 1,4 BENZODIAZEPIN 3 YL) 3 (3 METHYLPHENYL)UREA; 2 BENZYL 5 [N [(TERT BUTOXYCARBONYL)TRYPTOPHYL]AMINO] 1,3 DIOXOPERHYDROPYRIDO[1,2 C]PYRIMIDINE; AMYLASE; CHOLECYSTOKININ A RECEPTOR; CHOLECYSTOKININ A RECEPTOR ANTAGONIST; CHOLECYSTOKININ B RECEPTOR; CHOLECYSTOKININ OCTAPEPTIDE; DEVAZEPIDE; IQM 95333; UNCLASSIFIED DRUG;

ACINAR CELL; AMYLASE RELEASE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; NONHUMAN; RAT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

AMYLASES; ANIMALS; BENZODIAZEPINONES; BRAIN; CARBAMATES; DEVAZEPIDE; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; PANCREAS; PROTEIN BINDING; PYRIMIDINES; PYRIMIDINONES; RATS; RECEPTOR, CHOLECYSTOKININ A; RECEPTOR, CHOLECYSTOKININ B; RECEPTORS, CHOLECYSTOKININ; SINCALIDE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0042685644     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9703247     Document Type: Article

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