Synthesis and Antineoplastic Activity of N,N-Disubstituted Phenyl-3,6-Dimethyl-1,4-Dihydro-1,2,4,5-Tetrazine-1,4-Dicarboamide Derivatives

Yaoxue Xuebao

Volumn 35, Issue 10, 2000, Pages 796-

  Cai, Zhi Bin ^a   Zhou, Mao ^a   Hu, Wei Xiao ^a   Yang, Zhong Yu ^a  

^a ZHEJIANG UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

Antineoplastic activity; Organic synthesis; Tetrazine

Indexed keywords

ANTINEOPLASTIC AGENT; DRUG DERIVATIVE; TETRAZOLE DERIVATIVE; UREA;

ANIMAL; ARTICLE; CELL CULTURE; DRUG EFFECT; HUMAN; MOUSE; SYNTHESIS;

ANIMALS; ANTINEOPLASTIC AGENTS; HUMANS; MICE; TETRAZOLES; TUMOR CELLS, CULTURED; UREA;

EID: 0042683653     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (3)

1. Zhou M, Cai ZB, Yang ZY, et al. Studies on the synthesis of tetrazines and their antitumor activities (I). The N, N′-diphenyl-3,6-dimethyl-1, 4-dihydro-1, 2,4, 5-tetrazine-1, 4-dicarboamide [J]. J Zhejiang Univ Technol (in Chinese), 1999, 27(2):128-131.
2. Xu WF. Characteristic parameters of common substituting groups used in SAR [A]. Xu WF. Principles and Methods of Designing New Drugs [M]. Beijing: Publishing House of Medical Technology, 1997. 202-207.
3. Zhou M, Cai ZB, Yang ZY, et al. Synthesis of tetrazines and their antitumor activities II. Synthesis of 3, 6-dimethyl-1, 6-dihydro-1,2,4, 5-tetrazine by Pb/C catalytical oxidation [J]. Fine Chemicals (in Chinese), 1999,16(1):1-4.