Enhanced degradation of MDM2 by a nuclear envelope component, mouse germ cell-less

Biochemical and Biophysical Research Communications

Volumn 308, Issue 4, 2003, Pages 927-932

  Masuhara, Masaaki ^a   Nagao, Kenji ^b   Nishikawa, Mitsuo ^b   Kimura, Tohru ^a   Nakano, Toru ^a  

^a OSAKA UNIVERSITY   (Japan)

^b KIRIN BREWERY CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; PROTEIN MDM2; PROTEIN P53; UBIQUITIN;

ARTICLE; CELL NUCLEUS MEMBRANE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; GENE; GENE FUNCTION; GENETIC CODE; GERM CELL; GERM CELL LESS 1 GENE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; TRANSACTIVATION; TUMOR SUSCEPTIBILITY GENE 101; TWO HYBRID SYSTEM;

EID: 0042661005     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(03)01497-9     Document Type: Article

References (24)

1. Daujat S., Neel H., Piette J. MDM2: life without p53. Trends Genet. 17:2001;459-464.
2. Levine A.J. p53, the cellular gatekeeper for growth and division. Cell. 88:1997;323-331.
3. Momand J., Wu H.H., Dasgupta G. MDM2-master regulator of the p53 tumor suppressor protein. Gene. 242:2000;15-29.
4. Prives C. Signaling to p53: breaking the MDM2-p53 circuit. Cell. 95:1998;5-8.
5. Haupt Y., Maya R., Kazaz A., Oren M. Mdm2 promotes the rapid degradation of p53. Nature. 387:1997;296-299.
6. Kubbutat M.H., Jones S.N., Vousden K.H. Regulation of p53 stability by Mdm2. Nature. 387:1997;299-303.
7. Lane D.P., Hall P.A. MDM2-arbiter of p53's destruction. Trends Biochem. Sci. 22:1997;372-374.
8. Tao W., Levine A.J. Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53. Proc. Natl. Acad. Sci. USA. 96:1999;3077-3080.
9. Jongens T.A., Ackerman L.D., Swedlow J.R., Jan L.Y., Jan Y.N. Germ cell-less encodes a cell type-specific nuclear pore-associated protein and functions early in the germ-cell specification pathway of Drosophila. Genes Dev. 8:1994;2123-2136.
10. Jongens T.A., Hay B., Jan L.Y., Jan Y.N. The germ cell-less gene product: a posteriorly localized component necessary for germ cell development in Drosophila. Cell. 70:1992;569-584.
11. de la Luna S., Allen K.E., Mason S.L., La Thangue N.B. Integration of a growth-suppressing BTB/POZ domain protein with the DP component of the E2F transcription factor. EMBO J. 18:1999;212-228.
12. Kimura T., Yomogida K., Iwai N., Kato Y., Nakano T. Molecular cloning and genomic organization of mouse homologue of Drosophila germ cell-less and its expression in germ lineage cells. Biochem. Biophys. Res. Commun. 262:1999;223-230.
13. Leatherman J.L., Levin L., Boero J., Jongens T.A. Germ cell-less acts to repress transcription during the establishment of the Drosophila germ cell lineage. Curr. Biol. 12:2002;1681-1685.
14. Phillips R.L., Ernst R.E., Brunk B., Ivanova N., Mahan M.A., Deanehan J.K., Moore K.A., Overton G.C., Lemischka I.R. The genetic program of hematopoietic stem cells. Science. 288:2000;1635-1640.
15. Holaska J.M., Lee K.K., Kowalski A.K., Wilson K.L. Transcriptional repressor germ cell-less (GCL) and barrier-to-autointegration factor (BAF) compete for binding to emerin in vitro. J. Biol. Chem. 2002.
16. Nili E., Cojocaru G.S., Kalma Y., Ginsberg D., Copeland N.G., Gilbert D.J., Jenkins N.A., Berger R., Shaklai S., Amariglio N., Brok-Simoni F., Simon A.J., Rechavi G. Nuclear membrane protein LAP2beta mediates transcriptional repression alone and together with its binding partner GCL (germ-cell-less). J. Cell. Sci. 114:2001;3297-3307.
17. Leatherman J.L., Kaestner K.H., Jongens T.A. Identification of a mouse germ cell-less homologue with conserved activity in Drosophila. Mech. Dev. 92:2000;145-153.
18. Masuhara M., Nagao K., Nishikawa M., Sasaki M., Yoshimura A., Osawa M. Molecular cloning of murine STAP-1, the stem-cell-specific adaptor protein containing PH and SH2 domains. Biochem. Biophys. Res. Commun. 268:2000;697-703.
19. Kitajima K., Masuhara M., Era T., Enver T., Nakano T. GATA-2 and GATA-2/ER display opposing activities in the development and differentiation of blood progenitors. EMBO J. 21:2002;3060-3069.
20. Andrews N.C., Faller D.V. A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucleic Acids Res. 19:1991;2499.
21. Li L., Cohen S.N. Tsg101: a novel tumor susceptibility gene isolated by controlled homozygous functional knockout of allelic loci in mammalian cells. Cell. 85:1996;319-329.
22. Li L., Liao J., Ruland J., Mak T.W., Cohen S.N. A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control. Proc. Natl. Acad. Sci. USA. 98:2001;1619-1624.
23. Ruland J., Sirard C., Elia A., MacPherson D., Wakeham A., Li L., de la Pompa J.L., Cohen S.N., Mak T.W. p53 accumulation, defective cell proliferation, and early embryonic lethality in mice lacking tsg101. Proc. Natl. Acad. Sci. USA. 98:2001;1859-1864.
24. Kimura T., Ito C., Watanabe S., Takahashi T., Ikawa M., Yomogida K., Fujita Y., Ikeuchi M., Asada N., Matsumiya K., Okuyama A., Okabe M., Toshimori K., Nakano T. Mouse germ cell-less as an essential component for nuclear integrity. Mol. Cell. Biol. 23:2003;1304-1315.