메뉴 건너뛰기




Volumn 122, Issue 2, 2003, Pages 141-150

Profile of the anti-tumor effects of amrubicin, a completely synthetic anthracycline

Author keywords

Amrubicin hydrochloride; Calsed; DNA topoisomerase II inhibitor; Lung cancer; Malignant lymphoma

Indexed keywords

2,3 BIS(3,5 DIOXO 1 PIPERAZINYL)BUTANE; AMRUBICIN; AMRUBICINOL; ANTHRACYCLINE DERIVATIVE; ANTINEOPLASTIC AGENT; DOXORUBICIN; GYRASE INHIBITOR; UNCLASSIFIED DRUG;

EID: 0042656888     PISSN: 00155691     EISSN: None     Source Type: Journal    
DOI: 10.1254/fpj.122.141     Document Type: Review
Times cited : (11)

References (29)
  • 2
    • 0023631561 scopus 로고
    • Stereospecific total synthesis of 9-aminoanthracyclines: (+)-9-amino-9-deoxydaunomycin and related compounds
    • Ishizumi K, Ohashi N, Tanno, N. Stereospecific total synthesis of 9-aminoanthracyclines: (+)-9-amino-9-deoxydaunomycin and related compounds. J Org Chem. 1987;52:4477-4485.
    • (1987) J Org Chem , vol.52 , pp. 4477-4485
    • Ishizumi, K.1    Ohashi, N.2    Tanno, N.3
  • 3
    • 0024803685 scopus 로고
    • Antitumor activities of a novel 9-aminoanthracycline (SM-5887) against mouse experimental tumors and human tumor xenografts
    • Morisada S, Yanagi Y, Noguchi T, Kashiwazaki Y, Fukui M. Antitumor activities of a novel 9-aminoanthracycline (SM-5887) against mouse experimental tumors and human tumor xenografts. Jpn J Cancer Res. 1989;80:69-76.
    • (1989) Jpn J Cancer Res , vol.80 , pp. 69-76
    • Morisada, S.1    Yanagi, Y.2    Noguchi, T.3    Kashiwazaki, Y.4    Fukui, M.5
  • 4
    • 0031757797 scopus 로고    scopus 로고
    • Tumor-selective distribution of an active metabolite of the 9-aminoanthracycline amrubicin
    • Noguchi T, Ichii S, Morisada S, Yamaoka T, Yanagi Y. Tumor-selective distribution of an active metabolite of the 9-aminoanthracycline amrubicin. Jpn J Cancer Res. 1998;89:1061-1069.
    • (1998) Jpn J Cancer Res , vol.89 , pp. 1061-1069
    • Noguchi, T.1    Ichii, S.2    Morisada, S.3    Yamaoka, T.4    Yanagi, Y.5
  • 5
    • 0032445062 scopus 로고    scopus 로고
    • A new antitumor agent amrubicin induces cell growth inhibition by stabilizing topoisomerase II-DNA complex
    • Hanada M, Mizuno S, Fukushima A, Saito Y, Noguchi T, Yamaoka T. A new antitumor agent amrubicin induces cell growth inhibition by stabilizing topoisomerase II-DNA complex. Jpn J Cancer Res. 1998;89:1229-1238.
    • (1998) Jpn J Cancer Res , vol.89 , pp. 1229-1238
    • Hanada, M.1    Mizuno, S.2    Fukushima, A.3    Saito, Y.4    Noguchi, T.5    Yamaoka, T.6
  • 6
    • 0031786266 scopus 로고    scopus 로고
    • Cytotoxicity of amrubicin, a novel 9-aminoanthracycline, and its active metabolite amrubicinol on human tumor cells
    • Yamaoka T, Hanada M, Ichii S, Morisada S, Noguchi T, Yanagi Y. Cytotoxicity of amrubicin, a novel 9-aminoanthracycline, and its active metabolite amrubicinol on human tumor cells. Jpn J Cancer Res. 1998;89:1067-1073.
    • (1998) Jpn J Cancer Res , vol.89 , pp. 1067-1073
    • Yamaoka, T.1    Hanada, M.2    Ichii, S.3    Morisada, S.4    Noguchi, T.5    Yanagi, Y.6
  • 7
    • 0025042556 scopus 로고
    • Cytotoxicity and DNA damage caused by 4-demethoxydaunorubicin and its metabolite 4-demethoxy-13-hydroxydaunorubicin in human acute myeloid leukemia cells
    • Limonta M, Biondi A, Giudici G, et al. Cytotoxicity and DNA damage caused by 4-demethoxydaunorubicin and its metabolite 4-demethoxy-13-hydroxydaunorubicin in human acute myeloid leukemia cells. Cancer Chemother Pharmacol. 1990;26:340-342.
    • (1990) Cancer Chemother Pharmacol , vol.26 , pp. 340-342
    • Limonta, M.1    Biondi, A.2    Giudici, G.3
  • 8
    • 0026576715 scopus 로고
    • Anthracyclines and their C-13 alcohol metabolites: Growth inhibition and DNA damage following incubation with human tumor cells in culture
    • Kuffel MJ, Reid JM, Ames MM. Anthracyclines and their C-13 alcohol metabolites: growth inhibition and DNA damage following incubation with human tumor cells in culture. Cancer Chemother Pharmacol. 1992;30:51-57.
    • (1992) Cancer Chemother Pharmacol , vol.30 , pp. 51-57
    • Kuffel, M.J.1    Reid, J.M.2    Ames, M.M.3
  • 10
    • 0042731988 scopus 로고    scopus 로고
    • Japanese source
  • 11
    • 0031785994 scopus 로고    scopus 로고
    • In vivo efficacy and tumor-selective metabolism of amrubicin to its active metabolite
    • Noguchi T, Ichii S, Morisada S, Yamaoka T, Yanagi Y. In vivo efficacy and tumor-selective metabolism of amrubicin to its active metabolite. Jpn J Cancer Res. 1998;89:1055-1060.
    • (1998) Jpn J Cancer Res , vol.89 , pp. 1055-1060
    • Noguchi, T.1    Ichii, S.2    Morisada, S.3    Yamaoka, T.4    Yanagi, Y.5
  • 12
    • 0021891888 scopus 로고
    • DNA topoisomerases
    • Wang JC. DNA topoisomerases. Annu Rev Biochem. 1985;54:665-697.
    • (1985) Annu Rev Biochem , vol.54 , pp. 665-697
    • Wang, J.C.1
  • 13
    • 0024853052 scopus 로고
    • Topoisomerase-targeting antitumor drugs
    • D'Arpa P, Liu LF. Topoisomerase-targeting antitumor drugs. Biochim Biophys Acta. 1989;989:163-177.
    • (1989) Biochim Biophys Acta , vol.989 , pp. 163-177
    • D'Arpa, P.1    Liu, L.F.2
  • 14
    • 0024316466 scopus 로고
    • DNA topoisomerase poisons as antitumor drugs
    • Liu LF. DNA topoisomerase poisons as antitumor drugs. Annu Rev Biochem. 1989;58:351-375.
    • (1989) Annu Rev Biochem , vol.58 , pp. 351-375
    • Liu, L.F.1
  • 15
    • 0024329909 scopus 로고
    • In vitro and intracellular inhibition of topoisomerase II by the antitumor agent merbarone
    • Drake FH, Hofmann GA, Mong SM, et al. In vitro and intracellular inhibition of topoisomerase II by the antitumor agent merbarone. Cancer Res. 1989;49:2578-2583.
    • (1989) Cancer Res , vol.49 , pp. 2578-2583
    • Drake, F.H.1    Hofmann, G.A.2    Mong, S.M.3
  • 18
    • 0022656381 scopus 로고
    • DNA damage by antitumor acridines mediated mammalian DNA topoisomerase II
    • Rowe TC, Chen GL, Hsiang YH, Liu LF. DNA damage by antitumor acridines mediated mammalian DNA topoisomerase II. Cancer Res. 1986;46:2021-2026.
    • (1986) Cancer Res , vol.46 , pp. 2021-2026
    • Rowe, T.C.1    Chen, G.L.2    Hsiang, Y.H.3    Liu, L.F.4
  • 19
    • 0026723072 scopus 로고
    • DNA topoisomerase II immunostaining in human leukemia and rhadomyosarcoma cell lines
    • Wolverton JS, Danks MK, Granzen B, Beck WT. DNA topoisomerase II immunostaining in human leukemia and rhadomyosarcoma cell lines. Cancer Res. 1992;52:4248-4253.
    • (1992) Cancer Res , vol.52 , pp. 4248-4253
    • Wolverton, J.S.1    Danks, M.K.2    Granzen, B.3    Beck, W.T.4
  • 20
    • 0021329758 scopus 로고
    • Comparison of cytotoxicity and DNA breakage activity of congeners podophyllotoxin including VP-16-213 and VM 26: A quantitative structure-activity relationship
    • Long BH, Musial ST, Brattain MG. Comparison of cytotoxicity and DNA breakage activity of congeners podophyllotoxin including VP-16-213 and VM 26: a quantitative structure-activity relationship. Biochemistry. 1984;23:1183-1188.
    • (1984) Biochemistry , vol.23 , pp. 1183-1188
    • Long, B.H.1    Musial, S.T.2    Brattain, M.G.3
  • 21
    • 0025298540 scopus 로고
    • Antagonistic effect of aclarubicin on the cytotoxicity of etoposide and 4′-(9-acridinylamino) methanesulfon-m-anidine in human small cell lung cancer cell lines and topoisomerase II-mediated DNA cleavage
    • Jensen PB, Soørensen BS, Demant EJF, et al. Antagonistic effect of aclarubicin on the cytotoxicity of etoposide and 4′-(9-acridinylamino) methanesulfon-m-anidine in human small cell lung cancer cell lines and topoisomerase II-mediated DNA cleavage. Cancer Res. 1990;50:3311-3316.
    • (1990) Cancer Res , vol.50 , pp. 3311-3316
    • Jensen, P.B.1    Soørensen, B.S.2    Demant, E.J.F.3
  • 22
    • 0025988304 scopus 로고
    • Antagonistic effect of aclarubicin on daunorubicin-induced cytotoxicity in human small cell lung cancer cells: Relationship to DNA integrity and topoisomerase II
    • Jensen PB, Jensen PS, Demant EJF, et al. Antagonistic effect of aclarubicin on daunorubicin-induced cytotoxicity in human small cell lung cancer cells: relationship to DNA integrity and topoisomerase II. Cancer Res. 1991;51:5093-5099.
    • (1991) Cancer Res , vol.51 , pp. 5093-5099
    • Jensen, P.B.1    Jensen, P.S.2    Demant, E.J.F.3
  • 23
    • 0026425654 scopus 로고
    • Inhibition of intracellular topoisomerase II by antitumor bis (2,6-dioxopiperazine) derivatives: Mode of cell growth inhibition distinct from that of cleavable complex-forming type inhibitors
    • Ishida R, Miki T, Narita T, et al. Inhibition of intracellular topoisomerase II by antitumor bis (2,6-dioxopiperazine) derivatives: mode of cell growth inhibition distinct from that of cleavable complex-forming type inhibitors. Cancer Res. 1991;51:4909-4916.
    • (1991) Cancer Res , vol.51 , pp. 4909-4916
    • Ishida, R.1    Miki, T.2    Narita, T.3
  • 24
    • 0043233285 scopus 로고    scopus 로고
    • Japanese source
  • 25
    • 0026556959 scopus 로고
    • Phase I-II study of high-dose epirubicin in advanced non-small-cell lung cancer
    • Feld R, Wierzbicki R, Walde PLD, et al. Phase I-II study of high-dose epirubicin in advanced non-small-cell lung cancer. J Clin Oncol. 1992;10:297-303.
    • (1992) J Clin Oncol , vol.10 , pp. 297-303
    • Feld, R.1    Wierzbicki, R.2    Walde, P.L.D.3
  • 26
    • 0043233286 scopus 로고    scopus 로고
    • Japanese source
  • 27
    • 0041730680 scopus 로고    scopus 로고
    • Japanese source
  • 28
    • 0042231057 scopus 로고    scopus 로고
    • Japanese source
  • 29
    • 0042231058 scopus 로고    scopus 로고
    • Japanese source


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.