Tuberculosis: Looking beyond BCG vaccines

Journal of Postgraduate Medicine

Volumn 49, Issue 2, 2003, Pages 134-140

  Mustafa, Abu Salim ^a   Al Attiyah, R ^a  

^a KUWAIT UNIVERSITY   (Kuwait)

Author keywords

BCG; M. tuberculosis specific antigens; New vaccines; Tuberculosis

Indexed keywords

BCG VACCINE; CELL ANTIGEN; DNA VACCINE; EARLY SECRETORY ANTIGENIC TARGET 6; UNCLASSIFIED DRUG; VIRUS VECTOR;

BCG VACCINATION; BIOINFORMATICS; COMPARATIVE GENOMIC HYBRIDIZATION; DNA HYBRIDIZATION; DRUG EFFICACY; DRUG SAFETY; GENE DELIVERY SYSTEM; GENE IDENTIFICATION; GENE LOCATION; GENE SEQUENCE; GENETIC CODE; GENOME ANALYSIS; HUMAN; IMMUNOREACTIVITY; MORTALITY; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; OPEN READING FRAME; REVIEW; TUBERCULOSIS;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; BCG VACCINE; DISEASE MODELS, ANIMAL; HUMANS; MICE; TUBERCULOSIS; VACCINATION;

EID: 0042630994     PISSN: 00223859     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (58)

1. Dye C, Scheele S, Dolin P, Pathania V, Raviglione MC. Consensus statement. Global burden of tuberculosis: estimated incidence, prevalence, and mortality by country. WHO Global Surveillance and Monitoring Project. JAMA 1999;282:677-86.
2. Espinal MA, Laszlo A, Simonsen L, Boulahbal F, Kim SJ, Reniero A, et al. Global trends in resistance to antituberculosis drugs. World Health Organization-International Union against Tuberculosis and Lung Disease Working Group on Anti-Tuberculosis Drug Resistance Surveillance. N Engl J Med 2001;344:1294-303.
3. Fine PE. Variation in protection by BCG: implications of and for heterologous immunity. Lancet 1995;346:1339-45.
4. Brandt L, Feino Cunha J, Weinreich Olsen A, Chilima B, Hirsch P, Appelberg R, et al. Failure of the Mycobacterium bovis BCG vaccine: some species of environmental mycobacteria block multiplication of BCG and induction of protective immunity to tuberculosis. Infect Immun 2002;70:672-8.
5. Behr MA, Wilson MA, Gill WP, Salamon H, Schoolnik GK, Rane S, et al. Comparative genomics of BCG vaccines by whole-genome DNA microarray. Science 1999;284:1520-3.
6. Gordon SV, Brosch R, Billault A, Garnier T, Eiglmeier K, Cole ST. Identification of variable regions in the genomes of tubercle bacilli using bacterial artificial chromosome arrays. Mol Microbiol 1999;32: 643-55.
7. Lowrie DB, Tascon RE, Silva CL. Vaccination against tuberculosis. Int. Arch. Allergy Immunol 1995;108:309-12.
8. Talbot EA, Perkins MD, Silva SF, Frothingham R. Disseminated bacille Calmette-Guerin disease after vaccination: case report and review. Clin Infect Dis 1997;24:1139-46.
9. World Health Organization. Expanded program on immunization: joint WHO/UNICEF statement on immunization and AIDS. Weekly Epidemiol Rec 1987;62:53-4.
10. Mahairas GG, Sabo PJ, Hickey MJ, Singh DC, Stover CK (1996). Molecular analysis of genetic differences between Mycobacterium bovis BCG and virulent M. bovis. J Bacteriol 1996;178:1274-82.
11. Lagranderie MRR, Balazuc AM, Deriaud E, Leclerc CD, Gheorghiu M. Comparison of immune responses of mice immunized with five different Mycobacterium bovis BCG vaccine strains. Infect Immun 1996;64:1-9.
12. Brewer TF, Colditz GA. Relationship between Bacille Calmette-Guerin strains and the efficacy of BCG vaccine in the prevention of tuberculosis. Clin Infect Dis 1995;20:126-35.
13. Lewin KN, Liao R, Guinn KM, Hickey MJ, Smith H, Behr MA, et al. Deletion of RD1 from Mycobacterium tuberculosis mimics bacilli Calmette-Guerin attenuation. J Infect Dis 2003;187:117-23.
14. Pym AS, Brodin P, Brosch R, Huerre M, Cole ST. Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti. Mol Microbiol 2002; 46:709-17.
15. Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, et al. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 1998;393:537-44.
16. Ahmad S, Amoudy HA, Thole JE, Young DB, Mustafa AS. Identification of a novel protein antigen encoded by a Mycobacterium tuberculosis-specific RD1 region gene. Scand J Immunol 1999;49:515-22.
17. Berthet FX, Rasmussen PB, Rosenkrands I, Andersen P, Gicquel B. A Mycobacterium tuberculosis operon encoding ESAT-6 and a novel low-molecular-mass culture filtrate protein (CFP-10). Microbiology 1998;144:3195-203.
18. Ahmad S, MM Ali MM, Mustafa AS. Construction of a modified vector for efficient purification of recombinant Mycobacterium tuberculosis proteins expressed in Escherichia coli. Protein Expr Purif 2003; 29:167-75.
19. Mustafa AS. Development of new vaccines and diagnostic reagents against tuberculosis. Mol Immunol 2002;39:113-9.
20. Mustafa AS. Biotechnology in the development of new vaccines and diagnostic reagents against tuberculosis. Curr Pharm Biotechnol 2001; 2:157-73.
21. Mustafa AS, Cockle PJ, Shaban F, Hewinson RG, Vordermeier HM. Immunogenicity of Mycobacterium tuberculosis RD1 region gene products in infected cattle. Clin Exp Immunol 2002;130:37-42.
22. Mustafa AS, Amoudy HA, Wiker HG, Abal AT, Ravn P, Oftung F, et al. Comparison of antigen-specific T-cell responses of tuberculosis patients using complex or single antigens of Mycobacterium tuberculosis. Scand J Immunol 1998;48:535-43.
23. Ravn P, Demissie A, Eguale T, Wondwosson H, Lein D, Amoudy HA, et al. Human T cell responses to the ESAT-6 antigen from Mycobacterium tuberculosis. J Infect Dis 1999;179:637-45.
24. Arend SM, Andersen P, van Meijgaarden KE, Skjot RL, Subronto YW, van Dissel JT, et al. Detection of active tuberculosis infection by T cell responses to early-secreted antigenic target 6-kDa protein and culture filtrate protein 10. J Infect Dis 2000;181:1850-4.
25. Arend SM, Geluk A, van Meijgaarden KE, van Dissel JT, Theisen M, Andersen P, et al. Antigenic equivalence of human T-cell responses to Mycobacterium tuberculosis-specific RD1-encoded protein antigens ESAT-6 and culture filtrate protein 10 and to mixtures of synthetic peptides. Infect Immun 2000;68:3314-21.
26. Munk ME, Arend SM, Brock I, Ottenhoff THM, Andersen P. Use of ESAT-6 and CFP-10 antigens for diagnosis of extrapulmonary tuberculosis. J Infect Dis 2001;183:175-6.
27. Pathan AA, Wilkinson KA, Klenerman P, McShane H, Davidson RN, Pasvol G, et al. Direct ex vivo analysis of antigen-specific IFN-gamma-secreting CD4 T cells in Mycobacterium tuberculosis-infected individuals: associations with clinical disease state and effect of treatment. J Immunol 2001;167:5217-25.
28. Al-Attiyah R, AS Mustafa AS, AT Abal AT, NM Madi NM, P Andersen P. Restoration of mycobacterial antigen-induced proliferation and interferon-g responses in peripheral blood mononuclear cells of tuberculosis patients upon effective chemotherapy. FEMS Immunol Med Microbiol 2003; in press.
29. Lalvani A, Nagvenkar P, Udwadia Z, Pathan AA, Wilkinson KA, Shastri JS, et al. Enumeration of T cells specific for RD1-encoded antigens suggests a high prevalence of latent Mycobacterium tuberculosis infection in healthy urban Indians. J Infect Dis 2001;183:469-77.
30. Pathan AA, Wilkinson KA, Wilkinson RJ, Latif M, McShane H, Pasvol G, et al. High frequencies of circulating IFN-gamma-secreting CD8 cytotoxic T cells specific for a novel MHC class I-restricted Mycobacterium tuberculosis epitope in M. tuberculosis-infected subjects without disease. Eur J Immunol 2000;30:2713-21.
31. Al-Attiyah R, Shaban FA, Wiker HG, Oftung F, Mustafa AS. Synthetic peptides identify promiscuous human Th1 cell epitopes of the secreted mycobacterial antigen MPB70. Infect Immun 2003;71:1953-60.
32. Mustafa AS. HLA-restricted immune response to mycobacterial antigens: relevance to vaccine design. Hum Immunol. 2000;61:166-71.
33. Mustafa AS, Shaban FA, Abal AT, Al-Attiyah R, Wiker HG, Lundin KE, et al. Identification and HLA restriction of naturally derived Th1-cell epitopes from the secreted Mycobacterium tuberculosis antigen 85B recognized by antigen-specific human CD4(+) T-cell lines. Infect Immun 2000;68:3933-40.
34. Singh H, Raghava GP. ProPred: prediction of HLA-DR binding sites. Bioinformatics 2001;17:1236-7.
35. Mustafa AS, Oftung F, Amoudy HA, Madi NM, Abal AT, Shaban F, et al. Multiple epitopes from the Mycobacterium tuberculosis ESAT-6 antigen are recognized by antigen-specific human T cell lines. Clin Infect Dis 2000;30(Suppl 3):S201-5.
36. Mustafa AS, Shaban PA, Al-Attiyah R, Abal AT, El-Shamy AM, Andersen P, et al. Human Th1 cell lines recognize the Mycobacterium tuberculosis ESAT-6 antigen and its peptides in association with frequently expressed HLA class II molecules. Scand J Immunol 2003; 57:125-34.
37. Brandt L, Elhay M, Rosenkrands I, Lindblad EB, Andersen P. ESAT-6 subunit vaccination against Mycobacterium tuberculosis. Infect Immun 2000;68:791-5.
38. Olsen AW, Hansen PR, Holm A, Andersen P. Efficient protection against Mycobacterium tuberculosis by vaccination with a single subdominant epitope from the ESAT-6 antigen. Eur J Immunol 2000;30: 1724-32.
39. Weinrich Olsen A, van Pinxteren LA, Meng Okkels L, Birk Rasmussen P, Andersen P. Protection of mice with a tuberculosis subunit vaccine based on a fusion protein of antigen 85b and esat-6. Infect Immun 2001;69:2773-8.
40. Kamath AT, Feng CG, Macdonald M, Briscoe H, Britton WJ. Differential protective efficacy of DNA vaccines expressing secreted proteins of Mycobacterium tuberculosis. Infect Immun 1999;67: 1702-7.
41. Wu X, Yao G, Wang Y. Evaluation of protective efficacy of two tuberculosis DNA vaccines by lung histopathological analysis. Zhonghua Yu Fang Yi Xue Za Zhi 2001;35:384-6.
42. Brosch R, Gordon SV, Pym A, Eiglmeier K, Garnier T, Cole ST. Comparative genomics of the mycobacteria. Int J Med Microbiol 2000; 290:143-52.
43. Triccas JA, Sun L, Palendira U, Britton WJ. Comparative affects of plasmid-encoded interleukin 12 and interleukin 18 on the protective efficacy of DNA vaccination against Mycobacterium tuberculosis. Immunol Cell Biol 2002;80:346-50.
44. Lozes E, Huygen K, Content J, Denis O, Montgomery DL, Yawman AM, et al. Immunogenicity and efficacy of a tuberculosis DNA vaccine encoding the components of the secreted antigen 85 complex. Vaccine 1997;15:830-3.
45. McMurray DN. Recent advances in improved tuberculosis vaccines. Indian J Pediatr 2000;67(2 Suppl):S58-62.
46. Shata MT, Stevceva L, Agwale S, Lewis GK, Hone DM. Recent advances with recombinant bacterial vaccine vectors. Mol Med Today 2000;6:66-71.
47. Mollenkopf H, Dietrich G, Kaufmann SH. Intracellular bacteria as targets and carriers for vaccination. Biol Chem 2001;382:521-32.
48. Chambers MA, Williams A, Gavier-Widen D, Whelan A, Hall G, Marsh PD, et al. Identification of a Mycobacterium bovis BCG auxotrophic mutant that protects guinea pigs against M. bovis and hematogenous spread of Mycobacterium tuberculosis without sensitization to tuberculin. Infect Immun 2000;68:7094-9.
49. Pym AS, Brodin P, Majlessi L, Brosch R, Demangel C, Williams A, et al. Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis. Nat Med 2003, in press.
50. Smith DA, Parish T, Stoker NG, Bancroft GJ. Characterization of auxotrophic mutants of Mycobacterium tuberculosis and their potential as vaccine candidates. Infect Immun 2001;69:1142-50.
51. Collins DM, Wilson T, Campbell S, Buddle BM, Wards BJ, Hotter G, et al. Production of avirulent mutants of Mycobacterium bovis with vaccine properties by the use of illegitimate recombination and screening of stationary-phase cultures. Microbiology 2002;148:3019-27.
52. Sambandamurthy VK, Wang X, Chen B, Russell RG, Derrick S, Collins FM, et al. A pantothenate auxotroph of Mycobacterium tuberculosis is highly attenuated and protects mice against tuberculosis. Nat Med 2002;8:1171-4.
53. Feng CG, Palendira U, Demangel C, Spratt JM, Malin AS, Britton WJ. Priming by DNA immunization augments protective efficacy of Mycobacterium bovis Bacille Calmette-Guerin against tuberculosis. Infect Immun 2001;69:4174-6.
54. Ulmer JB. Tuberculosis DNA vaccines. Scand J Infect Dis 2001; 33: 246-8.
55. von Reyn CF, Vuola JM. New vaccines for the prevention of tuberculosis. Clin Infect Dis 2002;35:465-74.
56. Agger EM, Weldingh K, Olsen AW, Rosenkrands I, Andersen P. Specific acquired resistance in mice immunized with killed mycobacteria. Scand J Immunol 2002;56:443-7.
57. D'Souza S, Rosseels V, Denis O, Tanghe A, De Smet N, Jurion F, et al. Improved tuberculosis DNA vaccines by formulation in cationic lipids. Infect Immun 2002;70:3681-8.
58. Mollenkopf HJ, Groine-Triebkorn D, Andersen P, Hess J, Kaufmann SH. Protective efficacy against tuberculosis of ESAT-6 secreted by a live Salmonella typhimurium vaccine carrier strain and expressed by naked DNA. Vaccine 2001;19:4028-35.