Ifosfamide pharmacokinetics and hepatobiliary uptake in vivo investigated using single- and double-resonance 31P MRS

Magnetic Resonance in Medicine

Volumn 50, Issue 2, 2003, Pages 249-255

  Mancini, Laura ^a   Payne, Geoffrey S ^a   Dzik Jurasz, Andrzej S K ^a   Leach, Martin O ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

31P MRS; Double resonance spectroscopy; Ifosfamide; Pharmacokinetics; Polarization transfer

Indexed keywords

CHEMICAL SHIFT; MAMMALS; METABOLISM; POLARIZATION;

BIODISTRIBUTIONS; CHEMICAL SHIFT IMAGING; DOUBLE RESONANCE; DOUBLE-RESONANCE SPECTROSCOPY; IFOSFAMIDE; POLARIZATION TRANSFER; SIGNAL ENHANCEMENT; ^31P MRS;

PHARMACOKINETICS;

IFOSFAMIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG METABOLISM; GALLBLADDER; GUINEA PIG; HEPATOBILIARY SYSTEM; IMAGING SYSTEM; IN VIVO STUDY; MALE; NONHUMAN; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; POLARIZATION; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 0042592984     PISSN: 07403194     EISSN: None     Source Type: Journal    
DOI: 10.1002/mrm.10540     Document Type: Article

References (14)

1. Sladek NE. Oxazaphosphorines. In: Powis G, Prough RA, editors. Metabolism and action of anti-cancer drugs. Philadelphia: Taylor and Francis; 1987.
2. Fleming RA. An overview of cyclophosphamide and ifosfamide pharmacology. Pharmacotherapy 1997;17(15 Pt 2):146S-154S.
3. 31P MRS: pulse-and-acquire, decoupling, and polarization transfer. Magn Reson Med 2000;44:180-184.
4. Morris GA, Freeman R. Enhancement of nuclear magnetic resonance signals by polarization transfer. J Am Chem Soc 1979;101:760-762.
5. Klaassen CD, Watkins III JB. Mechanism of bile formation, hepatic uptake, and biliary excretion. Pharmacol Rev 1984;36:1-67.
6. Shaw HM, Heath TJ. Bile salts and bile formation in rats, rabbits and guinea pigs. Comp Biochem Physiol 1975;50A:615-619.
7. Ernst RR, Bodenhausen G, Wokaun A. Principles of nuclear magnetic resonance in one and two dimensions. Oxford: Clarendon Press; 1987.
8. Blechta V, Schraml J. Product operator formalism applied to large spin systems, with INEPT and DEPT examples. J Magn Reson 1986;69:293-301.
9. 31P MRS of the head and neck region. Magn Reson Imaging 2001;19:755-759.
10. Brown TR. Chemical shift imaging. In: Grant DM, Harris RK, editors. Encyclopedia of nuclear magnetic resonance. Vol. II. New York: Wiley; 1996. p 1261-1272.
11. Heid OH. Noniterative localised in vivo shimming in <15s. In: Proceedings of the 4th Annual Meeting of ISMRM, New York, 1996. p 363.
12. 31P nuclear magnetic resonance spectroscopy. J Pharmacol Exp Ther 1992;260:1133-1144.
13. van den Boogaart A, Van Hecke P, Van Huffel S, Graveron-Demilly D, van Ormondt D, de Beer R. MRUI: a graphical user interface for accurate routine MRS data analysis. In: Proceedings of the 13th Annual Meeting of ESMRMB, Prague, 1996. p 318.
14. Knijn A, de Beer R, van Ormondt D. Frequency-selective quantification in the time domain. J Magn Reson 1992;97:444-450.