Osteonecrosis in a patient with Gaucher's disease treated with enzyme replacement

Israel Medical Association Journal

Volumn 5, Issue 8, 2003, Pages 595-596

  Lebel, Ehud ^a   Elstein, Deborah ^a   Hain, Daniel ^a   Hadas Halpern, Irith ^a   Zimran, Ari ^a   Itzchaki, Menachem ^a  

^a SHAARE ZEDEK MEDICAL CENTER   (Israel)

Author keywords

Bone mineral densitometry; Enzyme replacement therapy; Gaucher disease; Magnetic resonance imaging; Osteonecrosis

Indexed keywords

ENZYME; HEMOGLOBIN; OPIATE DERIVATIVE;

AGED; ARTICLE; BONE MINERAL; BONE NECROSIS; CASE REPORT; DISEASE EXACERBATION; ENZYME REPLACEMENT; FEMUR; FEMUR HEAD; GAUCHER DISEASE; HEPATOSPLENOMEGALY; HOSPITAL ADMISSION; HUMAN; INFARCTION; KNEE PAIN; KNEE RADIOGRAPHY; LEUKOCYTE COUNT; OSTEOPOROSIS; PHYSICAL EXAMINATION; POLYMORPHONUCLEAR CELL; POSITRON EMISSION TOMOGRAPHY; THROMBOCYTE COUNT; TIBIA; WEIGHT BEARING;

AGED; DIAGNOSIS, DIFFERENTIAL; GAUCHER DISEASE; GLUCOSYLCERAMIDASE; HUMANS; KNEE JOINT; MAGNETIC RESONANCE IMAGING; MALE; OSTEONECROSIS; TIBIA; TREATMENT OUTCOME;

EID: 0042566225     PISSN: 15651088     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (5)

1. Beutler E, Grabowski GA. Gaucher disease. In: Scriver CR, Valle D, Beudet A, Sly WS, eds. The Metabolic and Molecular Bases of Inherited Diseases. Vol III. 2001:3635-68.
2. Barton NW, Brady RO, Dambrosia JM, et al. Replacement therapy for inherited enzyme deficiency: Macrophage-targeted glucocerebrosidase for Gaucher's disease. N Engl J Med 1991;324:1464-70.
3. Garfinkel D, Sidi Y, Ben-Bassat M, Salomon F, Hazaz B, Pinkhas J. Coexistence of Gaucher's disease and multiple myeloma. Arch Intern Med 1982;142:2229-30.
4. Bells RS, Mankin HJ, Doppelt SH. Osteomyelitis in Gaucher disease. J Bone Joint Surg Am 1986;68:1380-8.
5. Sidransky E, Ginns EI, Westman JA, et al. Pathological fractures may develop in Gaucher patients receiving enzyme replacement therapy. Am J Hematol 1994;47:247-9.