Severe 5-fluorouracil toxicity possibly secondary to dihydropyrimidine dehydrogenase deficiency in a breast cancer patient with osteogenesis imperfecta

European Journal of Cancer

Volumn 32, Issue 2, 1996, Pages 369-370

  Beuzeboc, P ^a   Pierga, J Y ^a   Stoppa Lyonnet, D ^a   Etienne, M C ^b   Milano, G ^b   Pouillart, P ^a  

^a INSTITUT CURIE   (France)

^b CENTRE ANTOINE LACASSAGNE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPHOSPHAMIDE; DIHYDROPYRIMIDINE DEHYDROGENASE; FLUOROURACIL; MITOXANTRONE;

ADULT; BREAST CANCER; CANCER CHEMOTHERAPY; CASE REPORT; ENZYME DEFICIENCY; FEMALE; HUMAN; LETTER; LEUKOPENIA; NEUTROPENIA; OSTEOGENESIS IMPERFECTA; PRIORITY JOURNAL; THROMBOCYTOPENIA;

ANTIMETABOLITES, ANTINEOPLASTIC; BREAST NEOPLASMS; DIHYDROURACIL DEHYDROGENASE (NADP); FEMALE; FLUOROURACIL; HUMANS; MIDDLE AGED; OSTEOGENESIS IMPERFECTA; OXIDOREDUCTASES;

EID: 0042541412     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/0959-8049(95)00573-0     Document Type: Letter

References (6)

1. Milano G, Etienne MC. Potential importance of dihydropyrimidine dehydrogenase in cancer chemotherapy. Pharmacogenetics 1994, 4, 301-306.
2. Diaso RB, Beavero JL, Carpenter JT, et al. Familial deficiency of dihydropyrimidine dehydrogenase. Biochemical basis for familial pyrimidinemia and severe 5 fluorouracil induced toxicity. J Clin Invest 1988, 81, 47-51.
3. Etienne MC, Lagrange JL, Dassonville O, et al. Population study of dihydropyrimidine dehydrogenase in cancer patients. J Clin Oncol 1994, 12, 2248-2253.
4. Nishida T, Oda T, Sugiyama T, Izumi S, Yakushiji M. Concurrent ovarian serous carcinoma and osteogenesis imperfecta. Arch Gynecol Obstet 1993, 53, 153-156.
5. Lyss AP, Lilenbaum RC, Harris BE, Diasio RB. Severe 5-fluorouracil toxicity in a patient with decreased dihydropyrimidine dehydrogenase activity. Cancer Invest 1993, 11, 239-240.
6. Yokota H, Fernandez-Salguero P, Furuya H, et al. cDNA cloning and chromosome mapping of human dihydropyrimidine dehydrogenase, an enzyme associated with 5-fluorouracil toxicity and congenital thymine uraciluria. J Biol Chem 1994, 269, 23192-23196.