Pharmacokinetics of nateglinide and its metabolites in subjects with type 2 diabetes mellitus and renal failure

Clinical Nephrology

Volumn 60, Issue 2, 2003, Pages 90-95

  Inoue, T ^a   Shibahara, N ^a   Miyagawa, K ^b   Itahana, R ^b   Izumi, M ^b   Nakanishi, T ^b   Takamitsu, Y ^b  

^a OSAKA MEDICAL COLLEGE   (Japan)

^b HYOGO COLLEGE OF MEDICINE   (Japan)

Author keywords

Hemodialysis; Nateglinide; Pharmacokinetics; Renal failure; Type 2 diabetes mellitus

Indexed keywords

DRUG METABOLITE; GLUCOSE; INSULIN; NATEGLINIDE; ORAL ANTIDIABETIC AGENT; SULFONYLUREA DERIVATIVE;

ADULT; AGED; AREA UNDER THE CURVE; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CREATININE CLEARANCE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EFFICACY; DRUG ELIMINATION; DRUG HALF LIFE; DRUG METABOLISM; DRUG SAFETY; DRUG URINE LEVEL; FEMALE; GLUCOSE BLOOD LEVEL; HEMODIALYSIS; HUMAN; HYPOGLYCEMIA; INSULIN RELEASE; KIDNEY FAILURE; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PHARMACOLOGICAL PARAMETERS; SIDE EFFECT; SINGLE DRUG DOSE;

EID: 0042532061     PISSN: 03010430     EISSN: None     Source Type: Journal    
DOI: 10.5414/cnp60090     Document Type: Article

References (15)

1. Akiyoshi M, Kakei M, Nakazaki M, Tanaka H 1995 A new hypoglycemic agent, A-4166, inhibits ATP-sensitive potassium channels in rat pancreatic β-cells. Am J Physiol 268: E185-193
2. Charpentier G, Riveline JP, Varroud-Vial M 2000 Management of drugs affecting blood glucose in diabetic patients with renal failure. Diab Metab 26 (Suppl 4): 73-85
3. Choudhury S, Hirschberg Y, Filipek R, Lasseter K, McLeod JF 2000 Single-dose pharmacokinetics of nateglinide in subjects with hepatic cirrhosis. J Clin Pharmacol 40: 634-640
4. Dornhorst A 2001 Insulinotropic meglitinide analogues. Lancet 358: 1709-1716
5. Harrower AD 1996 Pharmacokinetics of oral antihyperglycaemic agents in patients with renal insufficiency. Clin Pharmacokinet 31: 111-119
6. Karara AH, Dunning BE, McLeod JF 1999 The effect of food on the oral bioavailability and the pharmacodynamic actions of the insulinotropic agent nateglinide in healthy subjects. J Clin Pharmacol 39: 172-179
7. Kikuchi M 1996 Modulation of insulin secretion in non-insulin-dependent diabetes mellitus by two novel oral hypoglycaemic agents, NN623 and A4166. Diab Med 13: S151-S155
8. Morioka T, Emoto M, Tabata T, Shoji T, Tahara H, Kishimoto H, Ishimura E, Nishizawa Y 2001 Glycemic control is a predictor of survival for diabetic patients on hemodialysis. Diab Care 24: 909-913
9. Ono I, Matsuda K, Kanno S 1997 Determination of N-(trans-4-isopropylcyclohexanecarbonyl)-D-phenyl alanine and its metabolites in human plasma and urine by column-switching high-performance liquid chromatography with ultraviolet detection. J Chromatogr B Biomed Sci Appl 692: 397-404
10. Shinkai H, Nishikawa M, Sato Y, Toi K, Kumashiro I, Seto Y, Fukuma M, Dan K, Toyoshima S 1989 N-(cyclohexylcarbonyl)-D-phenylalanines and related compounds. A new class of oral hypoglycemic agents. J Med Chem 32: 1436-1441
11. Suzuki Y, Arakawa M, Gejyo F and Collaborative Study Group 1995 The treatment of the uraemic diabetic. Are we doing enough? A view from Japan. Nephrol Dial Transplant 10 (Suppl 7): 47-55
12. Takesada H, Matsuda K, Ohtake R, Mihara R, Ono I, Tanaka K, Naito M, Yatagai M, Suzuki E 1996 Structure determination of metabolites isolated from urine and bile after administration of AY4166, a novel D-phenylalanine-derivative hypoglycemic agent. Bioorg Med Chem 4: 1771-1781
13. van Staa T, Abenhaim L, Monette J 1997 Rate of hypoglycemia in users of sulphonylureas. J Clin Epidemiol 50: 735-741
14. Weaver ML, Orwig BA, Rodriguez LC, Graham ED, Chin JA, Shapiro MJ, McLeod JF, Mangold JB 2001 Pharmacokinetics and metabolism of nateglinide in humans. Drug Metab Dispos 29: 415-421
15. Wu MS, Yu CC, Yang CW, Wu CH, Haung JY, Hong JJ, Fan Chiang CY, Huang CC, Leu ML 1997 Poor pre-dialysis glycaemic control is a predictor of mortality in type II diabetic patients on maintenance hemodialysis. Nephrol Dial Transplant 12: 2105-2110