Development of 5-[(3-aminopropyl)phosphinooxy]-2-(hydroxymethyl)-4H-pyran- 4-one as a novel whitening agent

Chemical and Pharmaceutical Bulletin

Volumn 51, Issue 2, 2003, Pages 113-116

  Kim, Duck Hee ^a   Hwang, Jae Sung ^a   Baek, Heung Soo ^a   Kim, Kil Joong ^a   Lee, Byeong Gon ^a   Chang, Ihseop ^a   Kang, Hak Hee ^a   Lee, Ok Sub ^a  

^a AmorePacific Corporation   (South Korea)

Author keywords

Kojic acid; Kojyl APPA; Melanin synthesis; Tyrosinase inhibition

Indexed keywords

4 PYRONE DERIVATIVE; BLEACHING AGENT; KOJIC ACID; MELANIN; MONOPHENOL MONOOXYGENASE; DERMATOLOGICAL AGENT; PYRONE DERIVATIVE;

ANIMAL CELL; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VIVO CULTURE; MELANOCYTE; MELANOGENESIS; MOLECULAR STABILITY; MOUSE; NONHUMAN; PROTEIN CONTENT; SKIN COLOR; SKIN PERMEABILITY; SYNTHESIS; ANIMAL; BIOSYNTHESIS; CELL CULTURE; DRUG ANTAGONISM; DRUG EFFECT; FEMALE; GUINEA PIG; MELANOMA; METABOLISM; METHODOLOGY; PHARMACEUTICS; PHYSIOLOGY; SKIN; SKIN PIGMENTATION;

ANIMALS; DERMATOLOGIC AGENTS; FEMALE; GUINEA PIGS; HUMANS; MELANINS; MELANOCYTES; MELANOMA; MICE; PYRONES; SKIN; SKIN PIGMENTATION; TECHNOLOGY, PHARMACEUTICAL; TUMOR CELLS, CULTURED;

EID: 0042522479     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.51.113     Document Type: Article

References (15)

1. Hearing V. J., Jr., Methods. Enzymol., 142, 154-165 (1987).
2. Spritz R. A., Hearing V. J., Adv. Hum. Genet., 22, 1-45 (1994).
3. Prunieras M., Int. J. Dermatology, 25, 624-628 (1996).
4. McLeod S. D., Smith C., Mason R. S., J. Endocrinol., 146, 439-447 (1995).
5. Yada Y., Higuchi K., Imokawa G., J. Biol. Chem., 266, 18352-18357 (1991).
6. Yasuak O., Yutaka M., Fragrance J., 6, 53-58 (1990).
7. Lee O. S., Byon Y. H., Lee B. S., Hong J. E., Ko J. S., Cho Y. K., Lee H., U.S. Patent 5723645 (1998).
8. Vanni A., Gastaldi D., Giunata G., Annali. di Chimica., 80, 35-60 (1990).
9. Ley J. P., Bertram H.-J., Bioorg. Med. Chem., 9, 1879-1885 (2001).
10. Dooley T. P., Gadwood R. C., Kilgore K., Thomasco L. M., Skin Pharmacol., 7, 188-200 (1994).
11. Hearing V. J., Ekel T. M., Biochem. J., 157, 549-557 (1976).
12. Aberdam E., Roméro C., Ortonne J. P., J. Cell Sci., 106, 1015-1022 (1993).
13. Lotan R., Lotan D., Cancer Res., 40, 3345-3350 (1980).
14. Pomerantz S., Science, 164, 838-839 (1969).
15. Oikawa A. M., Nakayasu M., Nohara M., Tchen T. T., Biochim. Biophys. Acta, 148, 548-557 (1972).