Use of antibiotic-loaded polymethyl methacrylate beads in the management of musculoskeletal sepsis - A retrospective study

Journal of Orthopaedic Surgery

Volumn 11, Issue 1, 2003, Pages 73-79

  Mohanty, S P ^a   Kumar, M N ^a   Murthy, N S ^a  

^a KASTURBA MEDICAL COLLEGE   (India)

Author keywords

Antibiotic loaded polymethyl methacrylate beads; Chronic osteomyelitis

Indexed keywords

AMPICILLIN; ANTIBIOTIC AGENT; CEFUROXIME; CLOXACILLIN; COTRIMOXAZOLE; GENTAMICIN; POLY(METHYL METHACRYLATE);

ADULT; ARTICLE; CHRONIC OSTEOMYELITIS; CLINICAL ARTICLE; DECOMPRESSION SURGERY; FEMALE; HEMATOGENOUS OSTEOMYELITIS; HOSPITAL INFECTION; HUMAN; MALE; MUSCULOSKELETAL DISEASE; NEPHROTOXICITY; OPEN FRACTURE; OSTEOSYNTHESIS; OTOTOXICITY; RETROSPECTIVE STUDY; SEPSIS; SYSTEMIC DISEASE;

EID: 0042521000     PISSN: 10225536     EISSN: None     Source Type: Journal    
DOI: 10.1177/230949900301100115     Document Type: Article

References (13)

1. Buchholz HW, Elson RA, Heinert K. Antibiotic-loaded acrylic cement: current concepts. Clin Orthop 1984;190:96-108.
2. Klemm KW. Antibiotic bead chains. Clin Orthop 1993;295:63-76.
3. Salvati EA, Callaghan JJ, Brause BD, Klein RF, Small RD. Reimplantation in infection. Elution of gentamicin from cement and beads. Clin Orthop 1986;207:83-93.
4. Wahlig H, Dingeldein E, Bergmann R, Reuss K. The release of gentamicin from polymethylmethacrylate beads. An experimental and pharmacokinetic study. J Bone Joint Surg Br 1978;60:270-5.
5. Bayston R, Milner RD. The sustained release of antimicrobial drugs from bone cement. An appraisal of laboratory investigations and their significance. J Bone Joint Surg Br 1982;64:460-4.
6. Bowyer GW, Cumberland N. Antibiotic release from impregnated pellets and beads. J Trauma 1994;36:331-5.
7. Miclau T, Danhers LE, Lindsey RW. In vitro pharmacokinetics of antibiotic release from locally implantable materials. J Orthop Res 1993;11:627-32.
8. Sorensen TS, Sorensen AI, Merser S. Rapid release of gentamicin from collagen sponge. In vitro comparison with plastic beads. Acta Orthop Scand 1990;61:353-6.
9. Moon MS, Moon JL. Management of osteomyelitis. J Orthop Surg (Hong Kong) 2000;8:7-10.
10. Galey JP, Uhthoff JP. The use of gentamycin-PMMA beads in chronic osteomyelitis. In: Uhthoff HK, editor. Current concepts of infections in orthopaedic surgery. Berlin: Springer-Verlag; 1985.
11. Hedstrom SA, Lidgren L, Torholm C, Onnerfalt R. Antibiotic containing bone cement beads in the treatment of deep muscle and skeletal infections. Acta Orthop Scand 1980;51:863-9.
12. Majid SA, Lindberg LT, Gunterberg B, Siddiki MS. Gentamicin-PMMA beads in the treatment of chronic osteomyelitis. Acta Orthop Scand 1985;56:265-8.
13. Mackowiak PA, Jones SK, Smith JW. Diagnostic value of sinus-tract cultures in chronic osteomyelitis. JAMA 1978;239:2772-5.