Automated measurement of metastable zones for pharmaceutical compounds

Chemical Engineering Research and Design

Volumn 81, Issue 6, 2003, Pages 700-704

  Parsons, A R ^a   Black, S N ^a   Colling, R ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

Crystallization; Mestastable zone; Pharmaceutical compounds; Solubility curve; Turbidity

Indexed keywords

CRYSTALLIZATION; NUCLEATION; TURBIDITY;

PHARMACEUTICAL COMPOUNDS;

DRUG PRODUCTS;

MEASUREMENT METHOD;

EID: 0042520984     PISSN: 02638762     EISSN: None     Source Type: Journal    
DOI: 10.1205/026387603322150552     Document Type: Article

References (7)

1. Barrett, P. and Glennon, B., 2002, Characterizing the metastable zone width and solubility curve using lasentec FBRM and PVM, Trans IChemE, Part A. Chem Eng Res Des, 80: 799-805.
2. Fujiwara, M., Chow, P.S., Ma, D.L. and Braatz, R.D., 2002, Paracetamol crystallisation using laser backscattering and ATR-FTIR spectroscopy: metastability, agglomeration and control, Crystal Growth and Design, 2(5): 363-370.
3. Lange, N.A., 1961, Handbook of Chemistry, 10th edition (McGraw-Hill, New York).
4. Perry, R.H. and Green, D.W., 1999, Perry's Chemical Engineers' Handbook, 7th edition (McGraw-Hill, New York), pp 2-123.
5. Riesen, R., 1999, Industrial Crystallisation Processes-Process Optimisation using an Automatic Laboratory Reactor (Mettler-Toledo, Schwerzenbach, Switzerland).
6. Ulrich, J. and Titiz-Sargut, S., 2002, Influence of additives on the width of the metastable zone, Crystal Growth and Design, 2(5): 371-374.
7. Wood, W.M.L., 1997, Crystal science techniques in the manufacture of chiral compounds, in Chirality in Industry, Volume 2: the Commercial Manufacture and Applications of Optically Active Compounds, Collins, A.N., Sheldrake, G. and Crosby, J. (eds) (Wiley, New York).