The structure of Pseudomonas P51 Cl-muconate lactonizing enzyme: Co-evolution of structure and dynamics with the dehalogenation function

Protein Science

Volumn 12, Issue 9, 2003, Pages 1855-1864

  Kajander, Tommi ^a   Lehtiö, Lari ^a   Schlömann, Michael ^b   Goldman, Adrian ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b TU BERGAKADEMIE FREIBERG   (Germany)

Author keywords

Cl muconate lactonizing enzyme; Conformational changes; Crystallography; Dehalogenation; Mechanism; Mutagenesis; Structure function studies

Indexed keywords

ADIPIC ACID DERIVATIVE; CHLORINATED MUCONATE; ENZYME VARIANT; GLYCINE; LACTONE; MUCONATE LACTONIZING ENYZME; MUCONIC ACID; PHENYLALANINE; SERINE; THREONINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; COMPARATIVE STUDY; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DEHALOGENATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SUBSTRATE COMPLEX; HYDROGEN BOND; MOLECULAR DYNAMICS; MOLECULAR EVOLUTION; NONHUMAN; OPTICAL RESOLUTION; PRIORITY JOURNAL; PSEUDOMONAS; ROTATION; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; SURFACE CHARGE;

AMINO ACID SEQUENCE; BINDING SITES; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; HALOGENS; HYDROLASES; INTRAMOLECULAR LYASES; KINETICS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS; PROTEIN BINDING; PROTEIN CONFORMATION; PSEUDOMONAS; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS); NEGIBACTERIA; PSEUDOMONAS;

EID: 0042512001     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.0388503     Document Type: Article

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