Lower risk of Parkinson's disease in an admixed population of European and Indian origins

Movement Disorders

Volumn 18, Issue 8, 2003, Pages 912-914

  Ragothaman, Mona ^a   Murgod, Uday A ^a   Gururaj, Gopalkrishna ^a   Kumaraswamy, Subbakrishna D ^a   Muthane, Uday ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH AND NEUROSCIENCES   (India)

Author keywords

'Ethnicity; Admixed populations; Etiopathogenesis; Genetics; Parkinson's disease

Indexed keywords

MELANIN;

ADULT; AGED; ARTICLE; ASIA; CAUCASIAN; CELL COUNT; CONTROLLED STUDY; EPIDEMIOLOGICAL DATA; ETHNIC DIFFERENCE; EUROPE; FEMALE; GENETIC ANALYSIS; HEALTH CARE FACILITY; HUMAN; INDIA; INDIAN; MAJOR CLINICAL STUDY; MALE; MEDICAL SOCIETY; NERVE CELL; PARKINSON DISEASE; PATHOGENESIS; POPULATION RESEARCH; PREVALENCE; PRIORITY JOURNAL; RISK ASSESSMENT; SUBSTANTIA NIGRA; UNITED KINGDOM;

AGED; AGED, 80 AND OVER; EUROPE; FEMALE; GREAT BRITAIN; HUMANS; INDIA; MALE; MIDDLE AGED; PARKINSON DISEASE; PHENOTYPE; POPULATION DYNAMICS; PREVALENCE; RISK FACTORS;

EID: 0042474308     PISSN: 08853185     EISSN: None     Source Type: Journal    
DOI: 10.1002/mds.10449     Document Type: Article

References (11)

1. Muthane U, Jain S, Gururaj G. Hunting genes in Parkinson's disease from the roots. Med Hypotheses 2001;57:51-55.
2. Schrag A, Ben-Shlomo Y, Quinn N. Cross sectional prevalence survey of idiopathic Parkinson's disease and parkinsonism in London. BMJ 2000;321:21-22.
3. Chaudhuri KR, Hu MT, Brooks DJ. Atypical parkinsonism in Afro-Caribbean and Indian origin immigrants to the UK. Mov Disord 2000;15:18-23.
4. Muthane U, Yasha TC, Shankar SK. Low numbers and no loss of melanized nigral neurons with increasing age in normal human brains from India. Ann Neurol 1998;43:283-287.
5. HelpAge India. Ageing scenario. HelpAge India. Online at: http:// www.helpageindia.com. Accessed January 12, 2002.
6. Hughes AJ, Daniel SE, Lees AJ. Improved accuracy of clinical diagnosis of Lewy body Parkinson's disease. Neurology 2001;57: 1497-1499.
7. Anderson DW, Rocca WA, de Rijk MC, Grigoletto F, Melcon MO, Breteler MM, Maraganore DM. Case ascertainment uncertainties in prevalence surveys of Parkinson's disease. Mov Disord 1998; 13:626-632.
8. Litvan I, MacIntyre A, Goetz CG, et al. Accuracy of the clinical diagnoses of Lewy body disease, Parkinson disease, and dementia with Lewy bodies: a clinicopathologic study. Arch Neurol 1998; 55:969-978.
9. Bharucha NE, Bharucha EP, Bharucha AE, Bhise AV, Schoenberg BS. Prevalence of Parkinson's disease in the Parsi community of Bombay, India. Arch Neurol 1988;45:1321-1323.
10. Clayton D, McKeigue PM. Epidemiological methods for studying genes and environmental factors in complex diseases. Lancet 2001; 358:1356-1360.
11. McKeigue PM. Mapping genes underlying ethnic differences in disease risk by linkage disequilibrium in recently admixed populations. Am J Hum Genet 1997;60:188-196.