The novel gluconeogenesis inhibitors FR225659 and related compounds that originate from Helicomyces sp. No. 19353. II. Biological profiles

Journal of Antibiotics

Volumn 56, Issue 8, 2003, Pages 689-693

  Ohtsu, Yoshihiro ^a   Sasamura, Hiromi ^a   Shibata, Toshihiro ^a   Nakajima, Hidenori ^a   Hino, Motohiro ^a   Fujii, Takashi ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDIABETIC AGENT; FR 225659; NEW DRUG; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CULTURE MEDIUM; CYTOTOXICITY; DIABETES MELLITUS; DOSE RESPONSE; DRUG ABSORPTION; DRUG EFFICACY; DRUG METABOLISM; DRUG POTENCY; DRUG SYNTHESIS; FEMALE; FUNGAL STRAIN; GLUCONEOGENESIS; HELICOMYCES; HYPHOMYCETES; HYPOGLYCEMIA; IN VIVO STUDY; LIVER CELL CULTURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SPECIES DIFFERENCE; STRUCTURE ACTIVITY RELATION;

HELICOMYCES;

EID: 0042471678     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.56.689     Document Type: Article

References (11)

1. Owen, O. E.; P. Felig, A. P. Morgan, J, Wahren & G. F. Cahill Jr.: Liver and kidney metabolism during prolonged starvation. J. Clin. Invest. 48: 574-583, 1969
2. Defronzo, R. A.: Pathogenesis of type 2 (non-insulin dependent) diabetes mellitus: a balanced overview. Diabetologia 35: 389-397, 1992
3. Consoli, A.; N. Nurjhan, F. Capani & J. Gerich: Predominant role of gluconeogenesis in increased hepatic glucose production in NIDDM. Diabetes 38: 550-557, 1989
4. Rossetti, R. A.; A. Giaccari & R. A. Defronzo: Glucose toxicity. Diabetes Care 13(6): 610-630, 1990
5. Seglen, P. O.: Preparation of isolated rat liver cells. Methods Cell Biol. 13: 29-83, 1976
6. Swanson, M. A.: Methods Enzymol. 2: 541-543, 1955
7. McGilvery, R. W.: Methods Enzymol. 2: 543-546, 1955
8. Hanson, R. L. & J. B. Blair: Inhibition of gluconeogenesis and glycogenolysis by 2,5-anhydro-D-mannitol. J. Biol. Chem. 259: 218-223, 1984
9. Riquelme, P. T.; M. E. Wernette-Hammond, N. M. Kneer & H. A. Lardy: Mechanism of action of 2,5-anhydro-D-mannitol in hepatocytes. Effects of phosphorylated metabolites on enzymes of carbohydrate metabolism. J. Biol. Chem. 259: 5115-5123, 1984.
10. Herling, A. W & G. Schubert: Pharmacodynamic profile of a novel inhibitor of the hepatic glucose-6-phosphatase system. Am. J. Physiol. 274: G1087-1093, 1998
11. Raskin, P. & R. H. Unger: Hyperglucagonemia and its suppression. Importance in the metabolic control of diabetes. N. Engl. J. Med. 299: 433-436, 1978