Phenothiazinium-based photosensitizers: Antibacterials of the future?

Trends in Molecular Medicine

Volumn 9, Issue 7, 2003, Pages 283-285

  Phoenix, David A ^a   Harris, Frederick ^a  

^a UNIVERSITY OF CENTRAL LANCASHIRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; PHENOTHIAZINE DERIVATIVE; PHENOTHIAZINIUM; PHOTOSENSITIZING AGENT; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; DRUG ACTIVITY; DRUG MECHANISM; DRUG TARGETING; GRAM NEGATIVE BACTERIUM; MEMBRANE TRANSPORT; MULTIDRUG RESISTANCE; PHOTOOXIDATION; PHOTOTOXICITY; REVIEW;

BACTERIA (MICROORGANISMS); NEGIBACTERIA;

EID: 0042427660     PISSN: 14714914     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4914(03)00115-1     Document Type: Short Survey

References (20)

1. Phoenix, D.A. et al. (2003) Antimicrobial therapy: new solutions to an old problem. J. Eur. Cit. Qual. Life 1, 44-61
2. Harris, F., et al. Making light work of antimicrobial therapy. J. Eur. Cit. Qual. Life (in press)
3. Wainwright, M. (2002) The emerging chemistry of blood product disinfection. Chem. Soc. Rev. 31, 128-136
4. Wainwright, M. (2000) Methylene blue derivatives - suitable photoantimicrobials for blood product disinfection? Int. J. Antimicrob. Agents 16, 381-394
5. Komerik, N. et al. (2000) The effect of photodynamic action on two virulence factors of Gram-negative bacteria. Photochem. Photobiol. 72, 676-680
6. Wainwright, M. (2002) Methylene blue - a dye for all seasons? J. Chemother. 14, 431-443
7. Wainwright, M. (2002) Pathogen inactivation in blood products. Curr. Med. Chem. 9, 127-143
8. Wainwright, M. (1998) Photodynamic antimicrobial chemotherapy (PACT). J. Antimicrob. Chemother. 42, 13-28
9. Wainwright, M. et al. (1997) A study of photobactericidal activity in the phenothiazinium series. FEMS Immunol. Med. Microbiol. 19, 75-80
10. Wainwright, M. et al. (2001) Phenothiaziniums as putative photobactericidal agents for red blood cell concentrates. J. Chemother. 13, 503-509
11. Wainwright, M. et al. (2002) The use of New Methylene Blue in Pseudomonas aeriginosa biofilm destruction. Biofouling 18, 247-249
12. Wakayama, Y. et al. (1980) Photosensitized inactivation of E. coli cells in toluidine blue-light system. Photochem. Photobiol. 32, 601-605
13. Bhatti, M. et al. (1998) A study of the uptake of toluidine blue O by Porphyromonas gingivalis and the mechanism of lethal photosensitization. Photochem. Photobiol. 68, 370-376
14. Kawanashi, S. et al. (2001) Mechanism of guanine-specific DNA damage by oxidative stress and its role in carcinogenesis and ageing. Mutat. Res. 488, 65-76
15. Ravanat, J.-L. et al. (2000) Singlet oxygen induces oxidation of cellular DNA. J. Biol. Chem. 51, 40601-40604
16. Wainwright, M. et al. (1999) Photobactericidal activity of methylene blue derivatives against vancomycin-resistant Enterococcus spp. J. Antimicrob. Chemother. 44, 823-825
17. Sheparda, B.D. and Gilmore, M.S. (2002) Antibiotic-resistant enterococci: the mechanisms and dynamics of drug introduction and resistance. Microbes Infect. 4, 215-224
18. Wainwright, M. et al. (1998) Photobactericidal activity of phenothiazinium dyes against methicillin-resistant strains of Staphylococcus aureus. FEMS Microbiol. Lett. 160, 177-181
19. Wainwright, M. et al. (1997) Increased cytotoxicity and phototoxicity in the methylene blue series via chromophore methylation. J. Photochem. Photobiol. B 40, 233-239
20. Rojas, E. et al. (1999) Single cell gel electrophoresis assay: methodology and applications. J. Chromatogr. B Biomed. Sci. Appl. 722, 225-254