Angiotensin-converting enzyme gene polymorphism as a potent risk factor for developing microalbuminuria in Japanese patients with type 2 diabetes mellitus: A 9-year follow-up study

Journal of International Medical Research

Volumn 31, Issue 4, 2003, Pages 290-298

  Okuno, S ^a   Utsugi, T ^a   Ohno, T ^b   Ohyama, Y ^a   Uchiyama, T ^a   Tomono, S ^a   Kurabayashi, M ^a  

^a GUNMA UNIVERSITY   (Japan)

^b GUNMA PREFECTURAL CARDIOVASCULAR CENTER   (Japan)

Author keywords

Angiotensin converting enzyme gene polymorphism; Diabetic nephropathy; Microalbuminuria; Urine albumin excretion ratio

Indexed keywords

ALBUMIN; ANGIOTENSIN RECEPTOR ANTAGONIST; ANGIOTENSINOGEN; ANTIDIABETIC AGENT; CHOLESTEROL; DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPID; TRIACYLGLYCEROL;

ADULT; AGE; AGED; ALLELE; ARTICLE; BLOOD PRESSURE MEASUREMENT; BODY MASS; CLINICAL EXAMINATION; CLINICAL OBSERVATION; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DIABETIC RETINOPATHY; DISEASE COURSE; DISEASE DURATION; FEMALE; FOLLOW UP; GENE DELETION; GENE INSERTION; GENETIC ANALYSIS; GENETIC POLYMORPHISM; HUMAN; HYPERTENSION; JAPAN; LOGISTIC REGRESSION ANALYSIS; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MICROALBUMINURIA; NON INSULIN DEPENDENT DIABETES MELLITUS; POLYMERASE CHAIN REACTION; PROTEINURIA; RADIOIMMUNOASSAY; RISK ASSESSMENT; RISK FACTOR;

EID: 0042426151     PISSN: 03000605     EISSN: None     Source Type: Journal    
DOI: 10.1177/147323000303100406     Document Type: Article

References (27)

1. Mogensen C: Microalbuminuria predicts clinical proteinuria and early mortality in maturity onset diabetes. N Engl J Med 1984; 310: 356 - 360.
2. Mattock M, Morrish N, Viberti G, Keen H, Fitzgerald A, Jackson G: Prospective study of microalbuminuria as predictor of mortality in NIDDM. Diabetes 1992; 41: 736 - 741.
3. Diabetes Control and Complications Trial Research Group: The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993; 329: 977 - 986.
4. UK Prospective Diabetes Study (UKPDS) Group: Intensive blood glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS33). Lancet 1998; 352: 837 - 853.
5. Mathiesen E, Bonn B, Jensen T, Storm B, Deckert T: Relationship between blood pressure and urine albumin excretion in development of microalbuminuria. Diabetes 1990; 39: 245 - 249.
6. Haneda M, Kikkawa R, Togawa M, Koya D, Kajiwara N, Uzu T, et al: High blood pressure is a risk factor for the development of microalbuminuria in Japanese subjects with non-insulin-dependent diabetes mellitus. J Diabetes Complications 1992; 6: 181 - 185.
7. Sequist ER, Goets FC, Rich S, Barbosa J: Familial clustering of diabetic kidney disease: evidence for genetic susceptibility to diabetic nephropathy. N Engl J Med 1989; 320: 1161 - 1165.
8. Borch-Johnsen K, Norgaard K, Hommel E: Is diabetic nephropathy an inherited complication? Kidney Int 1992; 41: 719 - 722.
9. Doi Y, Yoshizumi H, Yoshinari M, Iino K, Yamamoto M, Ichikawa K, et al: Association between a polymorphism in the angiotensin-converting enzyme gene and microvascular complications in Japanese patients with NIDDM. Diabetologia 1996; 39: 97 - 102.
10. Jeffers BW, Estacio RO, Raynolds MV, Schrier RW: Angiotensin-converting enzyme gene polymorphism in non-insulin dependent diabetes mellitus and its relationship with diabetic nephropathy. Kidney Int 1997; 52: 473 - 477.
11. Ohno T, Kawazu S, Tomono S: Association analyses of the polymorphisms of angiotensin-converting enzyme and angiotensinogen genes with diabetic nephropathy in Japanese non-insulin-dependent diabetics. Metabolism 1996; 45: 218 - 222.
12. Marre M, Bernadet P, Gallois Y, Savagner F, Guyene TT, Hallab M, et al: Relationships between angiotensin I-converting enzyme gene polymorphism, plasma levels, and diabetic retinal and renal complications. Diabetes 1994; 43: 384 - 388.
13. Schmidt S, Schone N, Ritz E: Association of ACE gene polymorphism and diabetic nephropathy? The Diabetic Nephropathy Study Group. Kidney Int 1995; 47: 1176 - 1181.
14. Tarnow L, Cambien F, Rossing P, Nielsen FS, Hansen BV, Lecerf L, et al: Lack of relationship between an insertion/deletion polymorphism in the angiotensin I-converting enzyme gene and diabetic nephropathy and proliferative retinopathy in IDDM patients. Diabetes 1995; 44: 489 - 494.
15. Ringel J, Beige J, Kunz R, Distler A, Sharma AM: Genetic variants of the renin-angiotensin system, diabetic nephropathy and hypertension. Diabetologia 1997; 40: 193 - 199.
16. Panagiotopoulos S, Smith TJ, Aldred GP, Baker EJ, Jacklin CJ, Jerums G: Angiotensin-converting enzyme (ACE) gene polymorphism in type II diabetic patients with increased albumin excretion rate. J Diabetes Complications 1995; 9: 272 - 276.
17. Fujisawa T, Ikegami H, Shen GQ, Yamato E, Takekawa K, Nakagawa Y, et al: Angiotensin I-converting enzyme gene polymorphism is associated with myocardial infarction, but not with retinopathy or nephropathy, in NIDDM. Diabetes Care 1995; 18: 983 - 985.
18. Powrie JK, Watts GF, Ingham JN, Taub NA, Talmud PJ, Shaw KM: Role of glycemic control in development of microalbuminuria in patients with insulin dependent diabetes. BMJ 1994; 309: 1608 - 1612.
19. Davis MD, Meyers FL, Bresnick GH, de Venecia G: Current diagnosis and management of chorioretinal disease. In: Natural Evolution (L'Esperance FA, Jr, ed). St Louis: CV Mosby, 1977; pp179 - 184.
20. Miura J, Uchigata Y, Yokoyama H, Omori Y, Iwamoto Y: Genetic polymorphism of renin-angiotensin system is not associated with diabetic vascular complications in Japanese subjects with long-term insulin dependent diabetes mellitus. Diabetes Res Clin Pract 1999; 45: 41 - 49.
21. Fujisawa T, Ikegami H, Kawaguchi Y, Hamada Y, Ueda H, Shintani M, et al: Meta-analysis of association of insertion/deletion polymorphism of angiotensin I-converting enzyme gene with diabetic nephropathy and retinopathy. Diabetologia 1998; 41: 47 - 53.
22. Solini A, Dalla Vestra M, Saller A, Nosadini R, Crepaldi G, Fioretto P: The angiotensin-converting enzyme DD genotype is associated with glomerulopathy lesions in type 2 diabetes. Diabetes 2002; 51: 251 - 255.
23. Huang XH, Rantalaiho V, Wirta O, Pasternack A, Hiltunen TP, Koivula T, et al: Angiotensin-converting enzyme insertion/deletion polymorphism and diabetic albuminuria in patients with NIDDM followed up for 9 years. Nephron 1998; 80: 17 - 24.
24. Oue T, Namba M, Nakajima H, Ono A, Horikawa Y, Yamamoto K, et al: Risk factors for the progression of microalbuminuria in Japanese type 2 diabetic patients - a 10 year follow-up study. Diabetes Res Clin Pract 1999; 46: 47 - 55.
25. Ito Y, Utsugi T, Ohyama Y, Ohno T, Uchiyama T, Tomono S, et al: Role of blood pressure in the progression of microalbuminuria in elderly Japanese type 2 diabetic patients - 7 year follow up study. J Int Med Res 2001; 29: 280 - 286.
26. Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F: An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest 1990; 86: 1343 - 1346.
27. Tiret L, Rigat B, Visvikis S, Breda C, Corvol P, Cambien F, et al: Evidence from combined segregation and linkage analysis that a variant of the angiotensin I-converting enzyme (ACE) gene controls plasma ACE levels. Am J Hum Genet 1992; 51: 197 - 205.