A novel 5-HT receptor ligand and related cytotoxic compounds from an acid mine waste extremophile

Journal of Natural Products

Volumn 66, Issue 8, 2003, Pages 1097-1100

  Stierle, Andrea A ^a   Stierle, Donald B ^a   Goldstein, Eric ^a   Parker, Keith ^a   Bugni, Tim ^a,b   Baarson, Chad ^a   Gress, Julie ^a   Blake, Danielle ^a  

^a UNIVERSITY OF MONTANA   (United States)

^b UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIC AGENT; SEROTONIN 2A AGONIST; SEROTONIN 2A RECEPTOR; SESQUITERPENE DERIVATIVE;

ACID MINE DRAINAGE; ANIMAL CELL; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG ISOLATION; DRUG RECEPTOR BINDING; DRUG STRUCTURE; EMBRYO; FUNGUS; MIGRAINE; MOUSE; NONHUMAN; PITHOMYCES; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ANALYSIS;

ANIMALS; FUNGI; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MOLECULAR STRUCTURE; MONTANA; NIH 3T3 CELLS; RATS; RECEPTOR, SEROTONIN, 5-HT2A; SESQUITERPENES; TYROSINE; WASTE PRODUCTS; WATER;

ANIMALIA; EMBRYOPHYTA; FUNGI; PITHOMYCES;

EID: 0042423351     PISSN: 01633864     EISSN: None     Source Type: Journal    
DOI: 10.1021/np030044w     Document Type: Article

References (12)

1. Chatham, W. Montana Tech of the University of Montana, personal communication, 1997.
2. Mitman, G. A Final Report: Biological Survey of the Berkeley Pit Lake System; Mine Waste Technology Program Activity IV, Project 10; USEPA National Risk Management Lab, IAG ID# DW89938513-010, 1999.
3. Organisms were identified for us by Microbial ID, Inc., Delaware.
4. Wang, G. Y. S.; Borgeson, B. M.; Crews, P. Tetrahedron. Lett. 1997, 38 (49), 8449-8452.
5. Cole, R. J.; Cox, R. H. In Handbook of Toxic Fungal Metabolites; Academic Press: New York, 1981; pp 584-592.
6. Tfelt-Hansen, P. Neurologic Clinics: Advances in Headache; WB Saunders Co: Philadelphia, 1997; Vol. 15, pp 153-165.
7. Van Schie D. L.; de Jeu, R. M.; Steyn, D. W.; Odendaal, H. J.; van Geijn, H. P. Eur. J. Obstet. Gynecol. Reprod. Biol. 2002, May 10; 102 (2), 161-166.
8. Weber, J. T.; O'Connor, M. F.; Hayataka, K.; Colson, N.; Medora, R.; Russo, E. B.; Parker, K. K. J. Nat. Prod. 1997, 60, 651-653.
9. Ortiz, T. C.; Devereaux, M. C.; Parker, K. K. Pharmacology 2000, 60, 195-202.
10. Hikino, H.; Ito, K.; Takemoto, T. Chem. Pharm. Bull. 1968, 16, 1609-1610.
11. Bittner, M.; Silva, M.; Rozas, Z.; Papastergiou, F.; Jakupovic, J. Phytochemistry 1994, 36, 695-698.
12. Water samples were collected by James Madison, Montana Bureau of Mines and Geology.