A bead-alignment device with a bead-sized microchamber on a rotating cylinder for fabrication of a miniaturized probe array

Journal of Bioscience and Bioengineering

Volumn 96, Issue 1, 2003, Pages 86-88

  Noda, Hideyuki ^a   Kaise, Masahiro ^a   Kohara, Yoshinobu ^a,b   Okano, Kazunori ^a   Kambara, Hideki ^a  

^a HITACHI LTD   (Japan)

^b TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

Author keywords

100 m diameter bead; Bead alignment device; DNA probe array; Microchamber

Indexed keywords

CAPILLARITY; DNA; ROTATING MACHINERY;

MICROCHAMBER;

ALIGNMENT;

COMPLEMENTARY DNA; DNA;

ARTICLE; DNA HYBRIDIZATION; DNA PROBE; GENE FUNCTION; GENETIC VARIABILITY; HUMAN; MICROSCOPY; MOLECULAR BIOLOGY; TECHNOLOGY;

EID: 0042420525     PISSN: 13891723     EISSN: None     Source Type: Journal    
DOI: 10.1263/jbb.96.86     Document Type: Article

References (8)

1. Khan, J., Bittner, M.L., Chen, Y., Meltzer, P.S., and Trent, J.M.: DNA microarray technology: the anticipated impact on the study of human disease. Biochem. Biophys. Acta, 1423, 17-28 (1999).
2. Diamandis, E.P.: Sequencing with microarray technology - a powerful tool for molecular diagnostics. Clin. Chem., 46, 1523-1525 (2000).
3. Schena, M., Shalon, D., Davis, R. W., and Brown, P.O.: Quantitative monitoring of gene expression patterns with a complementary DNA microarray. Science, 270, 467-470 (1995).
4. Foder, S.P., Read, J.L., Pirrung, M.C., Stryer, L., Lu, A.T., and Solas, D.: Light-directed spatially addressable parallel chemical synthesis. Science, 251, 767-773 (1991).
5. Fulton, R. J., McDade, R. L., Smith, P. L., Kienker, L. J., and Kettman, J. R., Jr.: Advanced multiplex analysis with the Flow Matrix System. Clin. Chem., 43, 1749-1756 (1997).
6. Walt, D. R.: Bead-based fiber-optic arrays. Science, 287, 451-452 (2000).
7. Kohara, Y., Noda, H., Okano, K., and Kambara, H.: DNA probes on beads arrayed in a capillary, 'Bead array', exhibited high hybridization performance. Nucleic Acids Res., 30, e87 (2002).
8. Noda, H., Kohara, Y., Okano, K., and Kambara, H.: Automated bead-manipulating apparatus using a single-bead capturing technique for fabrication of a miniaturized bead-based DNA probe array. Anal. Chem., 75, 3250-3255 (2003).