Intestinal exposure to a parasite antigen in utero depresses cellular and cytokine responses of the mucosal immune system

Veterinary Immunology and Immunopathology

Volumn 93, Issue 3-4, 2003, Pages 91-105

  Paalangara, Reji ^a,d   McClure, Susan ^b   McCullagh, Peter ^a,c  

^a Biology and Environment   (Australia)

^b CSIRO   (Australia)

^c UNIVERSITY OF SYDNEY   (Australia)

^d TULANE NATIONAL PRIMATE RESEARCH CENTER   (United States)

Author keywords

Cytokine; IFA; IL 1 ; Incomplete Freund's adjuvant; Interleukin 1 ; Neuron specific enolase; NSE; Sheep mucosal immunology; Soluble protein of third stage larvae; SpL3; TcL3; TGF ; Third stage larvae; Trichostrongylus colubriformis

Indexed keywords

CD1 ANTIGEN; CD4 ANTIGEN; CD5 ANTIGEN; CD8 ANTIGEN; LYMPHOTOXIN; PARASITE ANTIGEN; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE; INTERLEUKIN 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTING CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; EOSINOPHIL; FEMALE; FETUS; GOBLET CELL; ILEUM; IMMUNOMODULATION; INTESTINE FLORA; INTESTINE MUCOSA; JEJUNUM; MUCOSAL IMMUNITY; NONHUMAN; PRENATAL EXPOSURE; PROTEIN EXPRESSION; SHEEP; STATISTICAL SIGNIFICANCE; TRICHOSTRONGYLUS COLUBRIFORMIS; ANIMAL; ANIMAL DISEASE; BIOSYNTHESIS; CD4 LYMPHOCYTE COUNT; CD4+ T LYMPHOCYTE; IMMUNOLOGY; LARVA; MALE; ORAL DRUG ADMINISTRATION; PARASITE IDENTIFICATION; PREGNANCY; SHEEP DISEASE; TRICHOSTRONGYLOSIS; TRICHOSTRONGYLUS;

ANIMALIA; OVIS ARIES; TRICHOSTRONGYLUS; TRICHOSTRONGYLUS COLUBRIFORMIS;

ADMINISTRATION, ORAL; ANIMALS; ANTIGEN-PRESENTING CELLS; ANTIGENS, CD5; ANTIGENS, HELMINTH; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; CYTOKINES; FEMALE; FETUS; IMMUNITY, MUCOSAL; INTERLEUKIN-1; JEJUNUM; LARVA; MALE; PARASITE EGG COUNT; PREGNANCY; SHEEP DISEASES; SHEEP, DOMESTIC; TRICHOSTRONGYLOSIS; TRICHOSTRONGYLUS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0042410858     PISSN: 01652427     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-2427(03)00050-3     Document Type: Article

References (51)

1. Aleksandersen M., Hein W.R., Landsverk T., McClure S. Distribution of lymphocyte subsets in the large intestinal lymphoid follicles of lambs. Immunology. 70:1990;391-397.
2. Alzuherri H.M., Woodall C.J., Clarke C.J. Increased intestinal TNF-α, IL-b and IL-6 expression in ovine paratuberculosis. Vet. Immunol. Immunopathol. 49:1996;331-345.
3. Arnold J.W., Klimpel G.R., Niesel D.W. Tumor necrosis factor (TNF a) regulates intestinal mucus production during salmonellosis. Cell. Immunol. 151:1993;336-344.
4. Birkebak T.A., Palmer G.H., Davis W.C., McElwain T.F. Quantitative characterization of the CD5 bearing lymphocyte population in the peripheral blood of normal sheep. Vet. Immunol. Immunopathol. 41:1994;181-186.
5. Dineen J.K., Windon R.G. The effect of sire selection on the response of lambs to vaccination with irradiated Trichostrongylus colubriformis larvae. Int. J. Parasitol. 10:1980;189-196.
6. Douch P.G., Green R.S., Morris C.A., McEewan J.C., Windon R.G. Phenotypic markers for selection of nematode-resistant sheep. Int. J. Parasitol. 26:1996;899-911.
7. Dutia B.M., Hopkins J. Analysis of the CD1 cluster in sheep. Vet. Immunol. Immunopathol. 27:1991;189-194.
8. Egan P.J., Andrews A.E., Barcham G.J., Brandon M.R., Nash A.D. Production and application of monoclonal antibodies to ovine interleukin-1 alpha and interleukin-1 beta. Vet. Immunol. Immunopathol. 41:1994a;241-257.
9. Egan P.J., Rothel J.S., Andrews A.E., Seow H.-F., Wood P.R., Nash A.D. Characterization of monoclonal antibodies to ovine tumor necrosis factor-alpha and development of a sensitive immunoassay. Vet. Immunol. Immunopathol. 41:1994b;259-274.
10. Else K.J., Finkelman F.D. Intestinal nematode parasites, cytokines and effector mechanisms. Int. J. Parasitol. 28:1998;1145-1158.
11. Emery D.L., McClure S.J., Wagland B.M. Production of vaccines against gastrointestinal nematodes of livestock. Immunol. Cell Biol. 71:1993;463-472.
12. Emery D.L., McClure S.J., Davey R.J., Bendixsen T. Induction of protective immunity to Trichostrongylus colubriformis in neonatal Merino lambs. Int. J. Parasitol. 29:1999;1037-1046.
13. Fahey K.J., Morris B. Humoral immune responses in foetal sheep. Immunology. 35:1978;651-661.
14. Finkelman F.D., Shea-Donohue T., Goldhill J., Sullivan C.A., Morris S.C., Madden K.B., Gause W.C., Urban J.F. Cytokine regulation of host defense against parasitic gastrointestinal nematodes: lessons from studies with rodent models. Annu. Rev. Immunol. 15:1997;505-533.
15. + T cells abrogates genetic resistance to Haemonchus contortus in sheep. Immunology. 78:1993;43-49.
16. Gonnella P.A., Chen Y., Inobe J., Komagata Y., Quartulli M., Weiner H.L. In situ immune response in gut-associated lymphoid tissue (GALT) following oral antigen in TCR-transgenic mice. J. Immunol. 160:1998;4708-4718.
17. Gorrell M.D., Willis G., Brandon M.R., Lascelles A.K. Lymphocyte phenotypes in the intestinal mucosa of sheep infected with Trichostrongylus colubriformis. Clin. Exp. Immunol. 72:1988;274-279.
18. Gregg P., Dineen J.K., Griffiths D.A. The effect of γ irradiation on the development of infective larvae of Trichostrongylus colubriformis in guinea pigs and sheep. Int. J. Parasitol. 2:1976;363-375.
19. Haimoto H., Takahashi Y., Koshikawa T., Nagura H., Kato K. Immunohistochemical localization of γ-enolase in normal human tissues other than nervous and neuroendocrine tissues. Lab. Invest. 52:1985;257-263.
20. Hamada Y., Kobayashi K., Brown W.R. Tumour necrosis factor-a decreases expression of the intestinal IgG Fc binding site by HT29-N2 cells. Immunology. 74:1991;298-303.
21. Hein, W.R., 1998. In: Pastoret, et al. (Eds.), Handbook of Vertebrate Immunology. Academic Press, New York, pp. 510-513.
22. Hein W.R., Dudler L., Mackay C.R. Surface expression of differentiation antigens on lymphocytes in the ileal and jejunal Peyer's patches of lambs. Immunology. 68:1989;365-370.
23. Holt P.G. Primary allergic sensitisation to environmental antigens: perinatal T cell priming as a determinant of responder phenotype in adulthood. J. Exp. Med. 183:1996;1297-1301.
24. Hopkins J., Dutia B.M. Monoclonal antibodies to the sheep analogues of human CD45 (leucocyte common antigen), MHC class I and CD5. Differential expression after lymphocyte activation in vivo. Vet. Immunol. Immunopathol. 24:1990;331-346.
25. Hugh A.R., Trevella W., Simpson-Morgan M.W., Morris B. The lymph-borne response of foetal lamb lymph nodes to challenge with Brucella abortus in utero. Aust. J. Exp. Biol. Med. Sci. 63:1985;381-395.
26. Kermanizadeh P., Hagan P., Crompton D.W.T. A differential staining method for mast cells and eosinophils in murine intestine, liver and spleen, liver and spleen. Parasitol. Today. 11:1995;194-196.
27. Knox D.P. Development of vaccines against gastrointestinal nematodes. Parasitology. 120:2000;S43-S612000.
28. Kon O.M., Kay A.B. T cells and chronic asthma. Int. Arch. Allergy Immunol. 118:1999;133-135.
29. Liesenfeld O., Kang H., Park D., Nguyen T.A., Parkhe C.V., Watanabe H., Abo T., Sher A., Remington J.S., Suzuki Y. TNF-α, nitric oxide and IFN-g are all critical for development of necrosis in the small intestine and early mortality in genetically susceptible mice infected perorally with Toxoplasma gondii. Parasite Immunol. 21:1999;365-376.
30. Mackay C.R., Maddox J.F., Brandon M.R. A monoclonal antibody to the p220 component of sheep LCA identifies B cells and a unique lymphocyte. Cell Immunol. 110:1987;46-55.
31. Maddox J.F., Mackay C.R., Brandon M.R. The sheep analogue of leukocyte common antigen (LCA). Immunology. 55:1985a;347-353.
32. Maddox J.F., Mackay C.R., Brandon M.R. Surface antigens, SBU-T4 and SBU-T8, of sheep T lymphocyte subsets defined by monoclonal antibodies. Immunology. 55:1985b;739-748.
33. McClure S.J., Emery D.L., Wagland B.M., Jones W.O. A serial study of rejection of Trichostrongylus colubriformis by immune sheep. Int. J. Parasitol. 22:1992;227-234.
34. + cells in vivo during primary infection with an enteric parasite (Trichostrongylus colubriformis) enhances protective immunity. Immunol. Cell Biol. 73:1995;552-555.
35. McClure S.J., Emery D.L., Bendixsent T., Davey R.F.E. Attempts to generate immunity against Tichostrongylus colubriformis and Haemonchus contortus in young lambs by vaccination with viable parasites. Int. J. Parasitol. 28:1998;739-746.
36. McClure, S.J., Emery, D.L., Steel, J.W.S., 2000. Host resistance against gastrointestinal parasites of sheep. In: Cronje, P.B. (Ed.), Ruminant Physiology: Digestion, Metabolism, Growth and Reproduction. CAB International, Wallingford, UK, pp. 425-436.
37. McCullagh P. Immunological tolerance of sheep to skin allografts. Transplantation. 46:1988;280-285.
38. McLeod R.S. Costs of major parasites to the Australian livestock industries. Int. J. Parasitol. 25:1995;1363-1367.
39. Mengheri E., Ciapponi L., Vignolini F., Nobili F. Cytokine gene expression in intestine of rat during the postnatal developmental period: increased IL-1 expression at weaning. Life Sci. 59:1996;1227-1236.
40. Miyasaka, M., Trnka, Z., 1985. Sheep as an experimental model for immunology: immunological techniques in vitro and in vivo. In: Lefkovits, I.A.P.B. (Ed.), Immunological Methods. Academic Press, New York, pp. 403-423.
41. Newton S.E., Munn E.A. The development of vaccines against gastrointestinal nematode parasites, particularly Haemonchus contortus. Parasitol. Today. 15:1999;116-122.
42. Omer F.M., Kurtzhals J.A., Riley E.M. Maintaining the immunological balance in parasitic infections: a role for TGF-b? Parasitol. Today. 16:2000;18-23.
43. Prendergast R.A., Silverstein A.M., Parshall C.J. Immunoglobulin production and allograft rejection in the fetal lamb. Transplantation. 8:1969;540-542.
44. Rothel J.S., Hurst L., Seow H.F., Pepin M., Berthon P., Corner L.A., Wood P.R. Analysis of ovine IL-1β production in vivo and in vitro by enzyme immunoassay and immunohistochemistry. Vet. Immunol. Immunopathol. 57:1997;267-278.
45. Santos L.M.B., Al-Sabbagh A., Londono A., Weiner H.L. Oral tolerance to myelin basic protein induces TGF-β secreting T cells in Peyer's patches. J. Immunol. 150:1993;115A.
46. Specian R.D., Oliver M.G. Functional biology of intestinal goblet cells. Am. J. Physiol. 260:1991;C183-C193.
47. Stewart M.L., McClure S.J., Rothwell T.L.W., Emery D.L. Changes in the enteric innervation of the sheep during primary or secondary immune responses to the nematode Trichostrongylus colubriformis. Reg. Immunol. 6:1995;460-470.
48. Suttle N.F., Knox D.P., Jackson F., Coop R.L., Angus K.W. Effects of dietary molybdenum on nematode and host during Trichostrongylus vitrinus infection in lambs. Res. Vet. Sci. 52:1992;224-229.
49. Van Houtert M.F.J., Sykes A.R. Implications of nutrition for the ability of ruminants to withstand gastrointestinal nematode infections. Int. J. Parasitol. 11:1996;1151-1168.
50. Whitlock H.V. Some modifications of the McMaster helminth egg-counting technique and apparatus. J. Coun. Sci. Ind. Res. 21:1948;177-179.
51. Winter M., Wright C., Blakeley D., Lee D. Mast cells and eosinophil staining. Parasitol. Today. 11:1995;426.