Plant nutritional elements and tropane alkaloid production in the roots of henbane (Hyoscyamus niger)

Pharmaceutical Biology

Volumn 41, Issue 4, 2003, Pages 226-230

  Pudersell, K ^a   Vardja, R ^b   Vardja, T ^b   Raal, A ^a   Arak, E ^a  

^a UNIVERSITY OF TARTU   (Estonia)

^b NONE

Author keywords

Atropa belladonna L.; Calcium; Datura stramonium L.; Hyoscyamine; Hyoscyamus muticus L.; Hyoscyamus niger L.; Root cultures; Scopolamine

Indexed keywords

BELLADONNA ALKALOID; CALCIUM; HYOSCYAMINE; MAGNESIUM; POTASSIUM; SCOPOLAMINE; TROPANE ALKALOID;

ARTICLE; CHEMICAL COMPOSITION; CULTURE MEDIUM; DATURA STRAMONIUM; DRUG SYNTHESIS; HYOSCYAMUS; HYOSCYAMUS MUTICUS; MORPHOLOGY; NONHUMAN; PLANT; PLANT GROWTH; PLANT NUTRIENT; PLANT ROOT;

ATROPA; ATROPA BELLADONNA; DATURA; DATURA STRAMONIUM; HYOSCYAMUS MUTICUS; HYOSCYAMUS NIGER;

EID: 0042388226     PISSN: 13880209     EISSN: None     Source Type: Journal    
DOI: 10.1076/phbi.41.4.226.15678     Document Type: Article

References (24)

1. Biondi S, Mengoli M, Mott D, Bagni N (1993): Hairy root cultures of Hyoscyamus muticus: Effect of polyamine biosynthesis inhibitors. Plant Physiol Biochem 31: 51-58.
2. Curtis WR, Wang P, Humphrey A (1995): Role of calcium and differentiation in enhanced sesquiterpene elicitation from calcium alginate-immobilized plant tissue. Enzyme Microb Technol 17: 554-557.
3. Hartmann T, Witte L, Oprach F, Toppel G (1986): Reinvestigation of the alkaloid composition of Atropa belladonna plants, root cultures and cell suspension cultures. Planta Med 52: 390-395.
4. Hashimoto T, Hayashi A, Amano Y, Kohno J, Iwanari H, Usuda S, Yamada Y (1991): Hyoscyamine 6-beta-hydroxylase, an enzyme involved in tropane alkaloid biosynthesis, is localized at the pericycle of the root. J Biol Chem 266(7): 4648-4653.
5. Hashimoto T, Kohno J, Yamada Y (1987): Epoxidation in vivo of hyoscyamine to scopolamine does not involve a dehydration step. Plant Physiol 84: 144-147.
6. Hilton MG, Wilson PDG (1995): Growth and the uptake of sucrose and mineral ions by transformed root cultures of Datura stramonium, Datura candida x aurea, Datura wrightii, Hyoscyamus muticus and Atropa belladonna. Planta Med 61: 345-350.
7. Jung D-A, Sung CK, Touno K, Yoshimatsu K, Shimomura K (2001): Cryopreservation of Hyoscyamus niger adventitious roots by vitrification. J Plant Physiol 158: 801-805.
8. Knop W (1865): Quantitative Untersuchungen über die ernahrungsprozesse der pflanzen. Landwirtsch Vers Stn 7: 93-107.
9. Kutchan TM (1995): Alkaloid biosynthesis - the basis of metabolic engineering of medical plants. Plant Cell 7: 1059-1071.
10. Leete E (1990): Recent development in the biosynthesis of the tropane alkaloids. Planta Med 56: 339-352.
11. Murashige T, Skoog F (1962): A revised medium for rapid growth and bio-assays with tobacco tissue culture. Physiol Plant 15: 473-497.
12. Oksman-Caldentey K-M (1987): Scopolamine and Hyoscyamine Production by Plants and Cell Cultures of Hyoscyamus muticus. Dissertation, University of Helsinki, Helsinki.
13. Oksman-Caldentey K-M, Hiltunen R (1996): Transgenic crops for improved pharmaceutical products. Field Crops Research 45: 57-69.
14. Oksman-Caldentey K-M, Sevon N, Vanhala L, Hiltunen R (1994): Effect of nitrogen and sucrose on the primary and secondary metabolism of transformed root cultures of Hyoscyamus muticus. Plant Cell Tiss Organ Cult 38: 263-272.
15. Oksman-Caldentey K-M, Strauss A, Hiltunen R (1987): Optimization of some parameters in cultivating scopolamine-producing cells of Hyoscyamus muticus. Acta Pharmac Fenn 96: 91-99.
16. Pinol MT, Palazon J, Cusido RM, Ribo M (1999): Influence of calcium ion-concentration in the medium on tropane alkaloid accumulation in Datura stramonium hairy roots. Plant Sci 41: 41-49.
17. Pudersell K, Arak E, Raal A (1999): Determination of hyoscyamine and scopolamine in plant extracts by HPLC. Eur J Pharm Sci 8 (Suppl): S31.
18. Pudersell K, Raidlo I, Vaher K, Vardja R, Vardja T, Pentšuk J, Arak E (2001): The ion chromatographic determination of the plant nutritional elements in the root cultures of henbane (Hyoscyamus niger L.). Abstracts of the XIV Helsinki University Congress of Drug Research, June 7-8, 2001. Eur J Pharm Sci 13 (Suppl): S39.
19. Rabot S, Peerless ACJ, Robins RJ (1995): TiglyoylCoA:pseudotropine acyl transferase - an enzyme of tropane alkaloid biosynthesis. Phytochemistry 39, 2: 315-322.
20. Rhodes MJC, Robins RJ, Lindsay E, Aird H, Payne J, Parr AJ, Walton NJ (1989): Regulation of secondary metabolism in transformed root cultures. In: Kurz WGW, Primary and Secondary Metabolism of Plant Cell Cultures. Berlin Heidelberg Springer-Verlag, pp. 58-70.
21. Robins RJ, Parr AJ, Bent EG, Rhodes MJC (1991): Studies on the biosynthesis of tropane alkaloids in Datura stramonium L. transformed root cultures. 1. The kinetics of alkaloid production and the influence of feeding intermediate metabolites. Planta 183: 185-195.
22. Tone S, Taya M, Kino-oka M (1997): Alteration of metabolite formation and morphological properties of hairy roots by environmental stimuli. In: Doran PM, ed., Hairy Roots, Culture and Applications. Amsterdam, The Netherlands Harwood Academic Publishers, pp. 65-72.
23. Utsal K, Arak E, Raal A, Pudersell K (1997): The X-ray diffractometric determination of some minerals of Hyoscyamus niger. Abstracts of the XIV Helsinki University Course in Drug Research. Eur J Pharm Sci 5 (Suppl): S46.
24. Walton NJ, Robins RJ, Peerless ACJ (1990): Enzymes of N-methylputrescine biosynthesis in relation to hyoscyamine formation in transformed root cultures of Datura stramonium and Atropa belladonna. Planta 182: 136-141.