Studies on structure modification of (+)-praeruptorin A

Yaoxue Xuebao

Volumn 37, Issue 7, 2002, Pages 527-534

  Wu, Xian Li ^a   Kong, Ling Yi ^a   Min, Zhi Da ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

( + ) praeruptorin A; Calcium antagonist; Structure modification

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; COUMARIN DERIVATIVE; HERBACEOUS AGENT; PRAERUPTORIN A;

ANIMAL; APIALES; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; ISOLATION AND PURIFICATION; MEDICINAL PLANT; MUSCLE CONTRACTION; RAT; SYNTHESIS; THORACIC AORTA; VASCULAR SMOOTH MUSCLE;

ANIMALS; AORTA, THORACIC; APIACEAE; CALCIUM CHANNEL BLOCKERS; COUMARINS; DRUGS, CHINESE HERBAL; MOLECULAR STRUCTURE; MUSCLE CONTRACTION; MUSCLE, SMOOTH, VASCULAR; PLANTS, MEDICINAL; RATS;

EID: 0042382976     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Chen ZX, Huang BS, She QL, et al. The chemical constituents of Bai-Hua-Qian-Hu [J]. Acta Pharm Sin, 1979, 14(8):486-496.
2. Kong LY. The chemical studies on active constituents and related compounds of decreasing pulmonary hypertension from Peucedanum praeruptorum [A]. Dissertation of Doctor Degree of Shengyang College of Pharmacy [D]. Shengyang: Shengyang College of Pharmacy, 1992.
3. Kozawa T, Sakai K, Uchida M, et al. Calcium antagonistic action of a coumarin isolated from "Qian-Hu", a Chinese traditional medicine [J]. J Pharm Pharmacol, 1981, 33(5): 317-320.
4. Rao MR, Shen XH, Zou X. Effects of praeruptorin C and E isolated from "Qian-Hu" on swine coronary artery and guinea pig atria [J]. Eur J Pharmacol, 1988, 155(3):293-296.
5. Rao MR, Liang MD, Liu F, et al. Calcium antagonistic action of praeruptorin C and E, and its effect on cardiovascular resistance [J]. News Communicat Chin Pharmacol Soc, 1984, 1(3-4):156.
6. Wu X, Rao MR. Effects of praeruptorin C on cytosolic free calcium in cultured rat heart cell [J]. Acta Pharm Sin, 1993, 28(10):728-731.
7. Wu X, Rao MR. Effects of praeruptorin C on isolated guinea pig atrium and myocardial compillance in patients [J]. Acta Pharmacol Sin, 1990, 11(3):235-238.
8. Wu X, Rao MR. Calcium-antagonistic effects of praeruptorin C on isolated guinea pig atria and rabbit aorta [J]. Chin J Pharmacol Toxicol, 1990, 4 (2):104-106.
9. Yang GR, Li QP, Rao MR. Protective effects of praeruptorin C and nifedipine on ischemia-reperfused injury in working rat hearts [J]. Acta Pharm Sin, 1992, 27(10): 729-733.
10. Yang GR, Li QP, Rao MR. Effects of praeruptorin C on hemodynamics of isolated rat heart with ischemia-reperfused damage [J]. Chin J Pharmacol Toxicol, 1995, 9(4):271-273.
11. Sun L, Rao MR, Liu PQ. Effects of praeruptorin C on cardiac dysfuntion, myocardial compliance and collagen content in renovascular hypertensive rats [J]. Acta Pharm Sin, 1997, 32(8):578-582.
12. Spedding M, Cavero I. "Calcium antagonists": a class of drugs with a bright future. Part II. Determination of basic pharmacological properties [J]. Life Sci, 1984, 35(6):575 -587.
13. Li H, Kashiwada Y, Cosentino LM, et al. Anti-AIDS Agents. 15. Synthesis and anti-HIV activity of dihydroseselins and related analogs [J]. J Med Chem, 1994, 37 (23):3947-3955.
14. Magiatis P, Melliou E, Skaltsounis AL, et al. Synthesis and cytotoxic activity of pyranocoumarins of the seselin and xanthyletin series [J]. J Nat Prod, 1998, 61(8):982-986.
15. Kong LY, Pei YH, Li X, et al. Review on chemical and pharmacological study of "Qian-Hu" [J]. World Notes Phant Med, 1991, 6(6):243-254.
16. Kong LY, Pei YH, Li X, et al. 2D NMR studies of relative configuration of acylated khellactones [J]. Chin J Magn Resonance, 1993, 10(4):433-440.
17. Kong LY, Li Y, Min ZD, et al. Coumarins from Peucedanum praeruptorum [J]. Photochemistry, 1996, 41 (5):1423-1426.
18. Kong LY, Pei YH, Li X, et al. Isolation and identification of praeuptorin B and C [J]. Acta Pharm Sin, 1993, 28(10):772-776.
19. Bal-Tembe S, Bhedi DN, Souza NJ, et al. Synthesis of ( ± )-praeruptorin A and related khellactone derivatives [J]. Heterocycles, 1987, 26(5):1239-1249.
20. Still WC, Kahn M, Mitra A. Rapid chromatographic technique for preparative separations with moderate resolution [J]. J Org Chem, 1978, 43(14):2923-2925.
21. Hassner A, Alxanian V. Direct room temperature esterification of carboxyltic acids [J]. Tetrahedron Lett, 1978, (46):4475-4478.
22. Nagao Y, Fujita E, Kohno T, et al. An efficient method for selective acetylation of alcoholic hydroxyl groups [J]. Chem Pharm Bull, 1981, 29(11):3202-3207.