Chylomicron-remnant-like particles inhibit the basal nitric oxide pathway in porcine coronary artery and aortic endothelial cells

Clinical Science

Volumn 105, Issue 3, 2003, Pages 363-371

  Goulter, Andrew B ^a,b   Avella, Michael ^a   Botham, Kathleen M ^a   Elliott, Jonathan ^a  

^a ROYAL VETERINARY COLLEGE   (United Kingdom)

^b Pharmagene Laboratories Ltd   (United Kingdom)

Author keywords

Atherosclerosis; Chylomicron remnants; Endothelial function; Nitric oxide (NO); Vasoconstriction dilation

Indexed keywords

APOLIPOPROTEIN E; CHYLOMICRON; COPPER SULFATE; CYCLIC GMP; N ACETYL S NITROSOPENICILLAMINE; N(G) NITROARGININE; NITRIC OXIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERY ENDOTHELIUM; ARTICLE; ATHEROSCLEROSIS; CELL CULTURE; CORONARY ARTERY; CULTURE MEDIUM; DEPOLARIZATION; ENDOTHELIUM CELL; ENZYME RELEASE; FEMALE; INCUBATION TIME; MALE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; SWINE; UREA CYCLE; VASODILATATION;

ANIMALS; AORTA; ARTERIOSCLEROSIS; CELLS, CULTURED; CHYLOMICRON REMNANTS; CHYLOMICRONS; COPPER SULFATE; CORONARY VESSELS; ENDOTHELIUM, VASCULAR; FEMALE; LIPOPROTEINS; MALE; NITRIC OXIDE; NITRIC OXIDE DONORS; NITRIC OXIDE SYNTHASE; NITROARGININE; OXIDATION-REDUCTION; PENICILLAMINE; SWINE;

EID: 0042376125     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20030039     Document Type: Article

References (55)

1. Cooke, J. P. and Dzau, V. J. (1997) Nitric oxide synthase: role in the genesis of vascular disease. Annu. Rev. Med. 148, 489-509
2. Ignarro, L. J., Cirino, G., Casini, A. and Napoli, C. (1999) Nitric oxide as a signaling molecule in the vascular system: an overview. J. Cardiovasc. Pharmacol. 34, 879-886
3. Landmesser, U., Hornig, B. and Drexler, H. (2000) Endothelial dysfunction in hypercholesterolemia: mechanisms, pathophysiological importance, and therapeutic interventions. Semin. Thromb. Hemost. 26, 529-537
4. Bult, H., Herman, A. and Matthys, K. (1999) Antiatherosclerotic activity of drugs in relation to nitric oxide function. Eur. J. Pharmacol. 375, 157-176
5. Gown, A. M., Tsukada, T. and Ross, R. (1986) Human atherosclerosis II. Immuno-cytochemical analysis of the cellular composition of human atherosclerotic lesions. Am. J. Pathol. 125, 191-200
6. Watanabe, T., Hirata, M., Yoshikawa, Y., Nagafuchi, Y. and Toyoshima, H. (1985) Role of macrophages in atherosclerosis. Lab. Invest. 53, 80-90
7. Bredt, D. S. and Snyder, S. H. (1994) Nitric oxide: a physiologic messenger molecule. Annu. Rev. Biochem. 63, 175-195
8. Steinberg, D. (1997) Low density lipoprotein oxidation and its pathobiological significance. J. Biol. Chem. 272, 20963-20966
9. Cox, D. A. and Cohen, M. L. (1996) Effects of oxidised low-density lipoprotein on vascular contraction and relaxation: clinical and pharmacological implications in atherosderosis. Pharmacol. Rev. 48, 3-19
10. Simon, B. C., Cunningham, L. D. and Cohen, R. A. (1990) Oxidized low density lipoproteins cause contraction and inhibit endothelium-dependent relaxation in the pig coronary artery. J. Clin. Invest. 86, 75-79
11. Mamo, J. C. L. (1995) Atherosclerosis as a post-prandial disease. Endocrinol. Metab. 2, 229-244
12. Groot, P. H. E., Van Stiphout, W. A., Krauss, X. H. et al. (1991) Postprandial lipoprotein metabolism in normolipidemic men with and without coronary artery disease. Arterioscler. Thromb. 11, 653-662
13. Patsch, J. R., Miesenbock, G., Hopferwieser, T. et al. (1992) Relation of triglyceride metabolism and coronary artery disease. Studies in the postprandial state. Arterioscler. Thromb. 12, 1336-1345
14. Proctor, S. D. and Mamo, J. C. L. (1998) Retention of fluorescent-labelled chylomicron remnants within the intima of the arterial wall: evidence that plaque cholesterol may be derived from post-prandial lipoproteins. Eur. J. Clin. Invest. 28, 497-503
15. Grieve, D. J., Avella, M. A., Elliott, J. and Botham, K. M. (1998) The influence of chylomicron remnants on endothelial cell function in the isolated perfused rat aorta. Atherosclerosis 139, 273-281
16. Mamo, J. C. L. and Wheeler, J. R. (1994) Chylomicrons or their remnants penetrate rabbit thoracic aorta as efficiently as do smaller macromolecules, including low-density lipoprotein, high-density lipoprotein and albumin. Coronary Artery Dis. 5, 695-705
17. Grieve, D. J., Avella, M. A., Botham, K. M. and Elliott, J. (1998) Effects of chylomicrons and chylomicron remnants on agonist-induced endothelium dependent relaxation of rat aorta. Eur. J. Pharmacol. 348, 181-190
18. Doi, H., Kugiyama, K., Ohgushi, M. et al. (1998) Remnants of chylomicron and very low density lipoprotein impair endothelium-dependent vasorelaxation. Atherosclerosis 137, 341-349
19. Pohl, U. and de Witm, C. (1996) Interaction of nitric oxide with myogenic and adrenergic vasoconstrictor processes in the control of microcirculatory blood flow. Pflügers Arch. 432, R107-R110
20. Murad, F. (1986) Cyclic guanosine monophosphate as a mediator of vasodilation. J. Clin. Invest. 78, 1-5
21. Pohl, U., Heydari, N. and Galle, J. (1995) Effects of LDL on intracellular free calcium and nitric oxide-dependent cGMP formation in porcine endothelial cells. Atherosclerosis 117, 169-178
22. Castro, A. F., Amorena, C., Muller, A., Ottaviano, G., Tellez-Inon, M. T. and Taquini A. C. (1998) Extracellular ATP and bradykinin increase cGMP in vascular endothelial cells via activation of PKC. Am. J. Physiol. 275, C113-C119
23. Hein, T. W., Liao, J. C. and Kuo, L. (2000) oxLDL specifically impairs endothelium-dependent, NO-mediated dilation of coronary arterioles. Am. J. Physiol. 278, H175-H183
24. Nuszkowski, A., Grabner, R., Marsche, G., Unbehaun, A., Malle, E. and Heller, R. (2001) Hypochlorite-modified low density lipoprotein inhibits nitric oxide synthesis in endothelial cells via an intracellular dislocalization of endothelial nitric-oxide synthase. J. Biol. Chem. 276, 14212-14221
25. Hadjiisky, P., Bourdillon, M. C. and Grosgogeat, Y. (1991) Experimental models of atherosclerosis. Contribution, limits and trends. Arch. Mal. Coeur. Vaiss. 84, 1593-1603
26. Lenzo, N. P., Martins, I., Mortimer, B. C. and Redgrave, T. G. (1988) Effects of phospholipid composition on the metabolism of triacylglycerol, cholesteryl ester and phosphatidylcholine from lipid emulsions injected intravenously into rats. Biochim. Biophys. Acta 960, 111-118
27. Diard, P., Malewiak, M., Lagrange, D. and Griglio, S. (1994) Hepatic lipase may act as ligand in the uptake of artificial chylomicron remnant-like particles by isolated rat hepatocytes. Biochem. J. 299, 889-894
28. Lambert, M. S., Avella, M. A., Berhane, Y., Shervill, E. and Botham, K. M. (2001) The fatty acid composition of chylomicron remnants influences their binding and internalisation by isolated hepatocytes. Eur. J. Biochem. 268, 3983-3992
29. Deckert, V., Persegol, L., Viens, L. et al. (1997) Inhibltors of arterial relaxation among components of human oxidized low-density lipoproteins. Cholesterol derivatives oxidized in position 7 are potent inhibitors of endothelium-dependent relaxation. Circulation 95, 723-731
30. Steinbrecher, U. P., Parthasarathy, S., Leake, D. S., Witztum, J. L. and Steinberg, D. (1984) Modification of low density lipoprotein by endothelial cells involves lipid. Proc. Natl. Acad. Sci. U.S.A. 81, 3883-3887
31. Peterson, G. L. (1977) A simplification of the protein assay method of Lowry et al. which is more generally applicable. Anal. Biochem. 83, 346-356
32. Redgrave, T. G. (1983) Formation and metabolism of chylomicrons. Int. Rev. Physiol. 28, 103-130
33. Redgrave, T. G. and Maranhao, R. C. (1985) Metabolism of protein-free lipid emulsion models of chylomicrons in rats. Biochim. Biophys. Acta 835, 104-112
34. Rensen, P. C., van Dijk, M. C., Havenaar, E. C., Bijsterbosch, M. K., Kruijt, J. K. and van Berkel, T. J. (1995) Selective liver targeting of antivirals by recombinant chylomicrons: a new therapeutic approach to hepatitis B. Nat. Med. 1, 221-225
35. Hultin, M., Carneheim, C., Rosenovist, K. and Olivecrona, T. (1995) Intravenous lipid emulsions: removal mechanisms compared to chylomicrons. J. Lipid Res. 36, 2174-2184
36. Sultan, F., Lagrange, D., Le Liepvre, X. and Griglio, S. (1989) Chylomicron-remnant uptake by freshly isolated hepatocytes. Effect of heparin and of hepatic triacylglycerol lipase. Biochem. J. 258, 587-594
37. Goulter, A. B., Avella, M. A., Elliott, J. and Botham, K. M. (2002) Chylomicron-remnant like particles inhibit receptor-mediated endothelium dependent vasorelaxation in pig coronary arteries. Clin. Sci. 103, 451-460
38. Tajima, M. and Sakagam, H. (2000) Tetrahydrobiopterin impairs the action of endothelial nitric oxide via superoxide derived from platelets. Br. J. Pharmacol. 131, 958-964
39. Berg, J. T., Deem, S., Kerr, M. E. and Swenson, E. R. (2000) Hemoglobin and red blood cells alter the response of expired nitric oxide to mechanical forces. Am. J. Physiol. Heart Circ. Physiol. 279, H2947-H2953
40. Franchi-Micheli, S., Failli, P., Mazzetti, L., Bani, D., Ciuffi, M. and Zilletti, L. (2000) Mechanical stretch reveals different components of endothelial-mediated vascular tone in rat aortic strips. Br. J. Pharmacol. 131, 1355-1362
41. Wallis, S. J. and Martin, W. (2000) Conditions permitting suppression of stretch-induced and vasoconstrictor tone by basal nitric oxide activity in porcine cerebral artery. Br. J. Pharmacol. 130, 567-574
42. Feron, O., Dessy, C., Moniotte, S., Desager, J. P. and Balligand, J. L. (1999) Hypercholesterolemia decreases nitric oxide production by promoting the interaction of caveolin and endothelial nitric oxide synthase. J. Clin. Invest. 103, 897-905
43. Kugiyama, K., Kerns, S. A., Morrisett, J. D., Roberts, R. and Henry, P. D. (1990) Impairment of endothelium-dependent arterial relaxation by lysolecithin in modified low-density lipoproteins. Nature (London) 344, 160-162
44. Galle, J., Bauersachs, J., Busse, R. and Bassenge, E. (1992) Inhibition of cyclic AMP- and cyclic GMP-mediated dilations in isolated arteries by oxidized low density lipoproteins. Arterioscler. Thromb. 12, 180-186
45. Murohara, T., Kugiyama, K., Ohgushi, M., Sugiyama, S., Ohta, Y. and Yasue, H. (1994) LPC in oxidized LDL elicits vasocontraction and inhibits endothelium-dependent relaxation. Am. J. Physiol. 267, H2441-H2449
46. G-monomethyl-L-arginine in isolated canine arteries. Eur. J. Pharmacol. 379, 167-173
47. Grieve, D. J., Avella, M. A., Botham, K. M., and Elliott, J. (2000) Chylomicron remnants potentiate phenylephrine-induced conctractions of rat aorta by an endothelium-dependent mechanism. Atherosclerosis 151, 471-480
48. Barba, G., Mullen, M. J., Donald, A., and Macallister, R. (1999) Determinants of the response of human blood vessels to nitric oxide donors in vivo. J. Pharm. Exp. Therap. 289, 1662-1668
49. Prabhakar, P., Thatte, H. S., Goetz, R. M., Cho, M. R., Golan, D. E. and Michel, T. (1998) Receptor-regulated translocation of endothelial nitric-oxide synthase. J. Biol. Chem. 273, 27283-27288
50. Zeiher, A. M., Drexler, H., Saurbier, B. and Just, H. (1993) Endothelium-mediated coronary blood flow modulation in humans. Effects of age, atherosclerosis, hypercholesterolemia, and hypertension. J. Clin. Invest. 92, 652-662
51. Galle, J., Mulsch, A., Busse, R. and Bassenge, E. (I991) Effects of native and oxidized low density lipoproteins on formation and inactivation of endothelium-derived relaxing factor. Arterioscler. Thromb. 11, 198-203
52. Schmidt, K., Graier, W. F., Kosmer, G. M., Mayer, B., Bohme, E. and Kukovetz, W. R. (1991) Oxidized low-density lipoprotein antagonizes the activation of purified soluble guanylate cyclase by endothelium-derived relaxing factor but does not interfere with its biosynthesis. Cell. Signalling 3, 361-367
53. Mitchell, J. A., de Nucci, G., Warner, T. D. and Vane, J. (1992) Different patterns of release of endothelium-derived relaxing factor and prostacyclin. Br. J. Pharmacol. 105, 485-489
54. Ezaki, M., Ikeda, M., Tomita, I. and Tomita, T. (1994) Inhibition of EDRF release by native low-density lipoprotein from cultured porcine endothelial cells through intracellular mechanisms. J. Cardiovasc. Pharmacol. 24, 552-558
55. Kume N. and Kita T. (2001) Roles of lectin-like oxidized LDL receptor-1 and its soluble forms in atherogenesis. Curr. Opin. Lipidol. 12, 419-423