Decreased arterial responses in WHHL rabbits, an animal model of spontaneous hypercholesterolemia and atherosclerosis

Experimental Animals

Volumn 51, Issue 5, 2002, Pages 493-499

  Yamada, Satoshi ^a   Ito, Takashi ^a   Adachi, Junko ^b   Ueno, Yasuhiro ^b   Shiomi, Masashi ^a  

^a KOBE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Atherosclerosis; Blood flow; Blood pressure; Endothelial cell function; Vasodilator; WHHL rabbit

Indexed keywords

ANIMAL; AORTA; ARTERIOSCLEROSIS; ARTERY; ARTICLE; CYTOLOGY; DISEASE MODEL; HEMODYNAMICS; HYPERCHOLESTEROLEMIA; MALE; PATHOLOGY; PATHOPHYSIOLOGY; RABBIT; VASCULAR ENDOTHELIUM; VASODILATATION;

ANIMALS; AORTA; ARTERIES; ARTERIOSCLEROSIS; DISEASE MODELS, ANIMAL; ENDOTHELIUM, VASCULAR; HEMODYNAMICS; HYPERCHOLESTEROLEMIA; MALE; RABBITS; VASODILATION;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 0042371976     PISSN: 13411357     EISSN: None     Source Type: Journal    
DOI: 10.1538/expanim.51.493     Document Type: Article

References (19)

1. Adachi, J., Morita, S., Yasuda, H., Miwa, A., Ueno, Y., Asano, M., and Tatsuno, Y. 1998. Elevated plasma nitrate in patients with crush syndrome caused by the Kobe earthquake. Clin. Chim. Acta 269: 137-145.
2. Ayajiki, K., Ozaki, M., Shiomi, M., Okamura, T., and Toda, N. 2000. Comparison of endothelium-dependent relaxation in carotid arteries from Japanese white and Watanabe heritable hyperlipidemic rabbits. J. Cardiovasc. Pharmacol. 36: 622-630.
3. Chinellato, A., Banchineri, N., Pandoifo, L., Ragazzi, E., Froldi, G., Norido, F., Caparrotta, L., and Fassina, G. 1991. Aortic response to relaxing agents in Watanabe heritable hyperlipidemic (WHHL) rabbits of different age. Atherosclerosis 89: 223-230.
4. Cirillo, R., Aliev, G., Italiano, G., and Prosdocimi, M. 1992. Functional responses of hindlimb circulation in aged normal and WHHL rabbits. Atherosclerosis 93: 133-144.
5. Furchgott, R.F. and Zawadzky, J.V. 1980. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 288: 373-376.
6. Ignarro, L.J., Byrns, R.E., Buga, G.M., and Eoods, K.S. 1987. Endothelium-derived relaxing factor from pulmonary artery and vein possesses Pharmacological and chemical properties that are identical to those for nitric oxide radical. Circ. Res. 61: 866-879.
7. Ito, T. and Shiomi, M. 2001. Cerebral atherosclerosis occurs spontaneously in homozygous WHHL rabbits. Atherosclerosis 156: 57-66.
8. Jayakody, R.L., Senaratne, M.P.J., Thomson, A.B.R., and Kappagoda, C.T. 1985. Cholesterol feeding impairs endothelium dependent relaxation of rabbit aorta. Can. J. Physiol. Pharmacol. 63: 1206-1209.
9. Kogata, S., Yamaguchi, Y., Shinozuka, K., and Kunitomi, M. 1998. Mechanisms of impairment of endothelium-dependent relaxation to acetylcholine in Watanabe heritable hyperlipidemic rabbit aortas. Clin. Exper. Pharmacol. Physiol. 25: 104-109.
10. Niederhoffer, N. and Szabo, B. 1999. Involvement of CB1 cannabinoid receptors in the EDHF-dependent vasorelaxation in rabbits. Br. J. Pharmacol. 126: 1383-1386.
11. Ohlmann, P., Martinez, M.C., Schneider, F., Stoclet, J.C., and Andriantsitohaina, R. 1997. Characterization of endothelium-derived relaxing factors released by bradykinin in human resistance arteries. Br. J. Pharmacol. 121: 657-664.
12. Parums, D.V., Cordell, J.L., Micklem, K., Heryet, A.R., Gatter, K.C., and Mason, D.Y. 1990. JC70: a new monoclonal antibody that detects vascular endothelium associated antigen on routinely processed tissue sections. J. Clin. Pathol. 43: 752-757.
13. Shiomi, M., Ito, T., Shiraishi, M., and Watanabe, Y. 1992. Inheritability of atherosclerosis and the role of lipoproteins as risk factors in the development of atherosclerosis in WHHL rabbits: Risk factors related to coronary atherosclerosis are different from those related to aortic atherosclerosis. Atherosclerosis 96: 43-52.
14. Shiomi, M., Ito, T., Tsukada, T., Yata, T., and Ueda, M. 1994. Cell compositions of coronary and aortic atherosclerotic lesions in WHHL rabbits differ: an immunohistochemical study. Arterioscler. Thromb. 14: 931-937.
15. Toda, N. and Okamura, T. 1989. Endothelium-dependent and - independent responses to vasoactive substances of isolated human coronary arteries. Am. J. Physiol. 257: H988-H995.
16. Tsukada, T., Rosenfeld, M.E., Ross, R., and Gown, A.M. 1986. Immunocytochemical analysis of cellular components in atherosclerotic lesions: use of monoclonal antibodies with Watanabe and fat-fed rabbits. Arteriosclerosis 6: 601-613.
17. Vogel, R.A. 1997. Coronary risk factors, endothelial function, and atherosclerosis: A review. Clin. Cardiol. 20: 426-432.
18. Yokoyama, M., Akita, H., Mizutani, T., Fukuzaki, H., and Watanabe, Y. 1983. Hyperreactivity of coronary arterial smooth muscles in response to ergonovine from rabbits with hereditary hyperlipidemia. Circ. Res. 53: 63-71.
19. Zanetti, M., Sato, J., Jost, C.J., Gloviczki, P., Katusic, Z.S., and O'Brien, T. 2001. Gene transfer of manganese superoxide dismutase reverses vascular dysfunction in the absence but not in the presence of atherosclerotic plaques. Hum. Gene Ther. 12: 1407-1416.