Influence of sex hormone antagonists on the anticonvulsant action of conventional antiepileptic drugs against amygdala-kindled seizures in male and female rats

European Neuropsychopharmacology

Volumn 13, Issue 4, 2003, Pages 257-265

  Borowicz, Kinga K ^a   Kleinrok, Zdzisław ^a   Czuczwar, Stanisław J ^a,b  

^a MEDICAL UNIVERSITY OF LUBLIN   (Poland)

^b INSTITUTE OF AGRICULTURAL MEDICINE   (Poland)

Author keywords

Amygdala kindled seizure; Antiepileptic drugs; Cyproterone; Mifepristone; Tamoxifen

Indexed keywords

AMINOPHYLLINE; ANTICONVULSIVE AGENT; BICUCULLINE; CARBAMAZEPINE; CYPROTERONE ACETATE; ESTRADIOL; KAINIC ACID RECEPTOR AGONIST; MIFEPRISTONE; N METHYL DEXTRO ASPARTIC ACID; PHENOBARBITAL; SEX HORMONE ANTAGONIST; STEROID HORMONE; STRYCHNINE; TAMOXIFEN; TESTOSTERONE;

AMNESIA; AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DATA ANALYSIS; DRUG EFFECT; FEMALE; GENDER; HYPOTHESIS; MALE; MOTOR DYSFUNCTION; MOTOR PERFORMANCE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; SEIZURE; STATISTICAL SIGNIFICANCE; TREATMENT OUTCOME;

EID: 0042349486     PISSN: 0924977X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0924-977X(03)00013-0     Document Type: Article

References (36)

1. Ang W.C., Farrell E., Vollenhoven B. Effect of hormone replacement therapies and selective estrogen receptor modulators in postmenopausal women with uterine leiomyomas: a literature review. Climacteric. 4:2001;284-292.
2. Backstrom T. Epileptic seizures in woman related to plasma estrogen and progesterone during the menstrual cycle. Acta Neurol. Scan. 54:1976;321-347.
3. Backstrom B., Zetterlund B., Blom S., Romano M. Effects of intravenous progesterone infusions on the epileptic discharge frequency in women with partial epilepsy. Acta Neurol. Scan. 60:1984;240-248.
4. Benassayag E. Indications of antiandrogens in benign hyperplasia of the prostate. J. Urol. (Paris). 101:1995;109-110. (in French).
5. Beylot C., Doutre M.S., Beylot-Barry M. Oral contraceptives and cyproterone acetate in female acne treatment. Dermatology. 196:1998;148-152.
6. Borowicz K.K., Kleinrok Z., Czuczwar S.J. Glutamate receptor antagonists differentially affect the protective activity of conventional antiepileptics against amygdala-kindled seizures in rats. Eur. Neuropsychopharmacol. 11:2001;61-68.
7. Borowicz K.K., Łuszczki J., Matuszek M., Kleinrok S.J., Czuczwar S.J. Effects of tamoxifen, mifepristone and cyproterone on the electroconvulsive threshold and pentetrazole-induced convulsions in mice. Pol. J. Pharmacol. 54:2002;103-109.
8. Butterbaugh G.C. Postictal events in amygdala-kindled female rats with and without estradiol replacement. Exp. Neurol. 95:1987;697-713.
9. Czuczwar S.J., Janusz W., Szczepanik B., Wamil A., Kleinrok Z. Effect of aminophylline upon the protective activity of common antiepileptic drugs and their plasma levels. Neurosci. Res. 6:1989;470-474.
10. Czuczwar S.J., Szczepanik B., Wamil A., Janusz W., Kleinrok Z. Differential effects of agents enhancing purinergic transmission upon the antielectroshock efficacy of carbamazepine, diphenylhydantoin, diazepam, phenobarbital, and valproate in mice. J. Neural Transm. 81:1990;153-166.
11. Dunham N.W., Miya T.S. A note on a simple approach for determining neurological deficits in rats and mice. J. Am. Pharmacol. Assoc. 46:1957;208-210.
12. Edwards H.E., Burnham W.M., MacLusky N.J. Testosterone and its metabolites affect afterdischarge thresholds and the development of amygdala kindled seizures. Brain. Res. 838:1999;151-157.
13. Falsetti L., Gambera A., Platto C., Legrenzi L. Management of hirsutism. Am. J. Clin. Dermatol. 1:2000;89-99.
14. Frye C.A., Bayon L.E. Cyclic withdrawal from endogenous and exogenous progesterone increases kainic acid and perforant pathway induced seizures. Pharmacol. Biochem. Behav. 62:1999;315-321.
15. Frye C.A., Reed T.A. Androgenic neurosteroids: anti-seizure effects in an animal model of epilepsy. Psychoneuroendocrinology. 23:1998;385-399.
16. Fujiwara Y., Sato M., Otsuki S. Interaction of carbamazepine and other drugs with adenosine (A1 and A2) receptors. Psychopharmacology. 90:1986;332-335.
17. Grunewald R.A., Aliberti V., Panayiotopoulos C.P. Exacerbation of typical absence seizures by progesterone. Seizure. 1:1992;137-138.
18. Holmes G.L., Weber D.A. The effects of progesterone on kindling: a developmental study. Dev. Brain Res. 16:1984;45-53.
19. Hom A.C., Butterbaugh G.C. Estrogen alters the acquisition of seizures kindled by repeated amygdala stimulation or pentylenetetrazol administration in ovariectomized female rats. Epilepsia. 27:1986;103-108.
20. Julien R.M., Fowler G.W., Danielson M.G. The effects of antiepileptic drugs on estrogen-induced electrographic spike wave discharges. J. Pharmacol. 193:1975;647-656.
21. Kokate T.G., Banks M.K., Magee T., Yamaguchi S., Rogawski M.A. Finasteride, a 5α-reductase inhibitor, blocks the anticonvulsant activity of progesterone in mice. J. Pharmacol. Exp. Ther. 288:1999;679-684.
22. Löscher W., Jäckel R., Czuczwar S.J. Is amygdala-kindling in rats a model for drug-resistant partial epilepsy? Exp. Neurol. 93:1986;211-226.
23. Löscher W., Schmidt D. Which animal models should be used in the search for new antiepileptic drugs? A proposal based on experimental and clinical considerations. Epilepsy Res. 2:1988;145-181.
24. Marangos P.J., Weiss S.R.B., Montgomery P., Patel J., Narang P.K., Cappabianca A.M., Post R.M. Chronic carbamazepine treatment increases brain adenosine receptors. Epilepsia. 26:1985;493-498.
25. Marcus E.M., Watson W., Goldman P.L. Effects of steroids on cerebral electrical activity. Acta Neurol. 15:1966;521-532.
26. Mattson R.H., Cramer J.A. Epilepsy, sex hormones and antiepileptic drugs. Epilepsia. 26:1985;s40-51.
27. Moran M.H., Smith S.S. Progesterone withdrawal I: proconvulsant effects. Brain Res. 807:1998;84-90.
28. Paxinos, G., Watson, C., 1986. The rat brain in stesiotaxic coordinates. 2nd ed. Academic Press, Sidney.
29. Perez-Gracia J.L., Carrasco E.M. Tamoxifen therapy for ovarian cancer in the adjuvant and advanced settings: systematic review of the literature and implications for future research. Gynecol. Oncol. 84:2002;201-209.
30. Racine R.J. Modification of seizure activity by electrical stimulation. II. Motor Seizure. Electroencephalogr. Clin. Neurophysio. 32:1972;281-284.
31. Rosse R.B., Mastropaolo J., Novitzki M.R., Deutsch S.I. Depot testosterone attenuates the anticonvulsant effect of flurazepam in mice. Psychoneuroendocrinology. 15:1990;83-85.
32. Schroder F.H. Cyproterone acetate - mechanism of action and clinical effectiveness in prostate cancer treatment. Cancer. 72:(Suppl. 12):1993;3810-3815.
33. Skerrit J.H., Johnston G.A.R., Chen Chow S. Interaction of the anticonvulsant carbamazepine with adenosine receptors. 2. Pharmacological studies. Epilepsia. 24:1983;643-650.
34. Venault P., Chapouthier G., De Carvalho L.P., Simiand J., Morre M., Dodd R.H., Rossier J. Benzodiazepines impair and β-carbolines enhance performance in learning and memory task. Nature. 321:1986;864-866.
35. Weir R.L., Padgett W., Daly J.W., Anderson S.M. Interaction of anticonvulsant drugs with adenosine receptors in the central nervous system. Epilepsia. 25:1984;492-498.
36. Wlaz P., Rolinski Z., Kleinrok Z., Czuczwar S.J. Influence of chronic aminophylline on the anticonvulsant efficacy of phenobarbital and valproate in mice. Epilepsia. 34:1993;385-389.