Effects of different phospholipids on the stabilities of doxorubicin liposomes in vitro and in vivo

Yaoxue Xuebao

Volumn 36, Issue 6, 2001, Pages 444-447

  Wang, Li ^a   Hou, Bao Guang ^a   Hou, Xin Pu ^a   Yu, Mei Li ^b   Yang, Jiang Shan ^b  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b Third Central Hospital   (China)

Author keywords

Egg phosphatidylcholine; Hydrogenated egg phosphatidylcholine; Liposomes; Pharmacokinetics

Indexed keywords

DOXORUBICIN; LIPOSOME; PHOSPHATIDYLCHOLINE;

ANIMAL; ARTICLE; CATTLE; DRUG STABILITY; HYDROGENATION; METABOLISM; RANDOMIZATION; RAT; RAT STRAIN;

ANIMALS; CATTLE; DOXORUBICIN; DRUG STABILITY; ENGLISH ABSTRACT; HYDROGENATION; LIPOSOMES; PHOSPHATIDYLCHOLINES; RANDOM ALLOCATION; RATS; RATS, WISTAR;

EID: 0042331930     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (5)

1. Singleton WS, Gray MS, Brown ML, et al. Chromatographically homogeneous lecithin from egg phosphalipids [J]. J Am Oil Chem Soc, 1965,42(1):53 -56.
2. New RRC. Liposomes: A Practical Approach [M]. New York: Oxford University Press, 1990.259-261.
3. Alvarez-Cedron L, Sayalero ML, Lanao JM. High-performance liquid chromatographic validated assay of doxorubicin in rat plasma and tissues [J]. J Chromatogr B, 1999,721(2):271-278.
4. Blok MC, Van Deenen LLM, De Gier J. The effect of cholesterol incorporation on the temperature dependence of water permeation through liposomal membranes prepared from phosphatidylcholines [J]. Biochem Biophys Acta , 1977,464(3):509-518.
5. Lasic DD, Martin FJ, Gabizon A, et al. Sterically stabilized liposomes: a hypothesis on the molecular origin of the extended circulation times [J]. Biochem Biophys Acta, 1991,1070(1):187-192.