Simultaneous determination of clofibrate and its active metabolite clofibric acid in human plasma by reversed-phase high-performance liquid chromatography with ultraviolet absorbance detection

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 794, Issue 2, 2003, Pages 343-351

  Du, Lihong ^a   Xu, Yang ^a   Musson, Donald G ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Clofibrate; Clofibric acid

Indexed keywords

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; MEDICAL APPLICATIONS; METABOLITES;

SOLID-PHASE EXTRACTIONS (SPE);

BIOMEDICAL ENGINEERING;

ACETIC ACID DERIVATIVE; CLOFIBRATE; CLOFIBRIC ACID;

ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG HYDROLYSIS; HUMAN; INTERMETHOD COMPARISON; PLASMA; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SOLID PHASE EXTRACTION;

EID: 0042329455     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1570-0232(03)00500-2     Document Type: Article

References (9)

1. Angelin B., Einarsson K., Leijd B. Eur. J. Clin. Invest. 9:1979;185.
2. Bateson M.C., Maclean D., Ross P.E., Bouchier I.A. Am. J. Dig. Dis. 23:1978;623.
3. Schlierf G., Chwat M., Feueborn E. Atherosclerosis. 36:1980;323.
4. Hall M.J., Nelson L.M., Russell R.I., Howard A.N. Atherosclerosis. 39:1981;511.
5. Barra J., Taburet A.M., Jardel A., Fessi H., Puisieux F. J. Chromatogr. B. 661:1994;178.
6. Garrett R.E., Gardner M.R. J. Pharm. Sci. 71:1982;14.
7. Meffin P.J., Zilm D.M., Veenendaal J.R. J. Pharmacol. Exp. Ther. 227:1983;732.
8. Veenendaal J.R., Meffin P.J. J. Chromatogr. B. 223:1981;147.
9. Veenendaal J.R., Brooks P.M., Meffin P.J. Clin. Pharmacol. Ther. 29:1981;351.