Enhancement of nasal absorption of a peptidal drug by powder formulations

Oto-Rhino-Laryngology Tokyo

Volumn 46, Issue SUPPL. 1, 2003, Pages 20-23

  Yamamoto, Yoji ^a   Dohi, Masahiko ^a   Uejima, Yasuhide ^a  

^a NONE

Author keywords

Molecular weight; Nasal absorption; Nasal formulation; Peptide; Powder formulation

Indexed keywords

EXCIPIENT; HYDROXYPROPYLCELLULOSE; LEUPRORELIN; MICROCRYSTALLINE CELLULOSE; PEPTIDE; SALCATONIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; LEUKOCYTE; MOLECULAR WEIGHT; NONHUMAN; NOSE MUCOSA; PEPTIDE ANALYSIS; POWDER; PROTEINASE INHIBITION; RABBIT;

EID: 0042318762     PISSN: 03869687     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (5)

1. Dohi M, Nishibe Y, Kawabe H, Makino Y, Suzuki Y, et al: The enhanced nasal absorption of peptides using powder preparations with mixed base materials. Proceed Int'l Symp Control Rel Bioact Mater 23: 483-484, 1996.
2. Masuda K, Kamimura T, Watanabe K, Suga T, Kanesaki M, et al: Pharmacological activity of the C-terminal and N-terminal domains of secretory leukoprotease inhibitor in vitro. Br J Pharmacol 115: 883-888, 1995.
3. Dohi M, Nishibe Y, Fukazawa H, Makino Y, Uejima Y, et al: Effect of microenvironment of ingredients in nasal powder preparations with mixed base materials. Proceed Int'l Symp Control Rel Bioact Mater 24: 413-414, 1997.
4. Dohi M, Nishibe Y, Makino Y, Suzuki Y: Enzymatic barrier to nasal delivery of salmon calcitonin in rabbits. In abstract: International Symposium Delivery of Protein Drugs-The Next 10 Years: 97-100, kyoto, Japan, September 2-4, 1993.
5. Maitani Y, Machida Y, Nagai T: Influence of molecular weight and charge on nasal absorption of dextran and DEAE-dextran in rabbits. Int J Pharm 49: 23-27, 1989.