Histologic changes to olfactory epithelium in hypothyroid rats

Otolaryngology - Head and Neck Surgery

Volumn 129, Issue 1, 2003, Pages 24-32

  Dhong, Hun Jong ^a   Kim, Hyo Yeol ^b   Ha, Byung Suk ^b  

^a Sungkyunkwan University School of Medicine   (South Korea)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CYCLINE; GENE PRODUCT; NEURON SPECIFIC ENOLASE; PROPYLTHIOURACIL; PROTEIN GENE PRODUCT 9.5; THYROID HORMONE; UNCLASSIFIED DRUG; ENOLASE; THIOL ESTER HYDROLASE; UBIQUITIN THIOLESTERASE;

ADOLESCENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DENSITY; CELL PROLIFERATION; CONTROLLED STUDY; HISTOPATHOLOGY; HYPOTHYROIDISM; IMMUNOHISTOCHEMISTRY; MATURATION; NONHUMAN; NOSE MUCOSA; OLFACTORY RECEPTOR; RAT; THICKNESS; TIME; TREATMENT DURATION; ANIMAL; CHEMICALLY INDUCED DISORDER; EVALUATION; METABOLISM; OLFACTORY EPITHELIUM; PATHOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; HYPOTHYROIDISM; MODELS, ANIMAL; OLFACTORY MUCOSA; OLFACTORY RECEPTOR NEURONS; PHOSPHOPYRUVATE HYDRATASE; PROLIFERATING CELL NUCLEAR ANTIGEN; PROPYLTHIOURACIL; RATS; RATS, SPRAGUE-DAWLEY; THIOLESTER HYDROLASES; THYROID HORMONES; TIME FACTORS; UBIQUITIN THIOLESTERASE;

EID: 0042285561     PISSN: 01945998     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0194-5998(03)00530-8     Document Type: Article

References (20)

1. Graziadei PPC, Monti-Graziadei GA. Neurogenesis and neuron regeneration in the olfactory system of mammals, I: morphological aspects of differentiation and structural organization of the olfactory sensory neurons. J Neurocytol 1979;8:1-18.
2. Timiras PS. Thyroid hormone and the developing brain. In: Handbook of human growth and developmental biology, Vol 1, Part C. Boca Raton (FL): CRC Press; 1988. Pp 59-82.
3. Bernal J, Nunez J. Thyroid hormones and brain development. Eur J Endocrinol 1995;133:390-8.
4. Rakic P. Limits of neurogenesis in primates. Science 1985;227:1054-6.
5. Dozin B, De Nayer P. Triiodothyronine receptors in adult rat brain: topographical distribution and effect of hypothyroidism. Neuroendocrinology 1984;39:261-6.
6. Pymirat J. Thyroid hormone receptors in rat brain. Progr Neurobiol 1992;39:281-94.
7. McConnell RJ, Menendez CE, Smith FR, et al. Defects of taste and smell in patients with hypothyroidism. Am J Med 1975;59:354-64.
8. Paternostro MA, Meisami E. Developmental plasticity of the rat olfactory receptor sheet as shown by complete recovery of surface area and cell number from early hypothyroid growth retardation. Dev Brain Res 1993;76:151-61.
9. The Universities Federation for Animal Welfare (UFAW). Standards in laboratory animal management. London: Pennant Press; 1984.
10. Beard MD, Mackay-Sim A. Loss of sense of smell in adult hypothyroid mice. Brain Res 1987;36:181-9.
11. Paternostro MA, Meisami E. Lack of thyroid hormones but not their excess affects the maturation of olfactory receptor neurons: a quantitative morphologic study in the postnatal rat. Int J Dev Neurosci 1991;9:439-50.
12. Patemostro MA, Meisami E. Essential role of thyroid hormone in maturation of olfactory receptor neurons: an immunocytochemical study of number and cytoarchitecture of OMP-postive cellls in developing rats. Int J Dev Neurosci 1996;14:867-80.
13. Graziadei PPC, Monti-Graziadei GA. Continuous nerve cell renewal in the olfactory system. In: Handbook of sensory physiology, Vol 9. Berlin: Springer; 1978. pp 27-58.
14. Jackson P, Thompson RJ. The demonstration of new human brain-specific proteins by high-resolution 2-dimensional polyacrylamide gel electophoresis. J Neurol Sci 1981;49:429-38.
15. Iganawa T, Han H, Kanazawa H, et al. Immunohisto-chemical localization of protein gene product 9.5 (PGP9.5) in sensory paraneuron of the rat. Biomed Res 1992;13:225-30.
16. Takahashi S, Iwanaga T, Takahashi Y, et al. Neuron specific enolase, neurofilament protein, and S-100 protein in the olfactory mucosa of human fetuses. Cell Tissue Res 1984;238:231-4.
17. Paternostro MA, Meisami E. Quantitative [3H]thymidine autoradiography of neurogenesis in olfactory epithelium of developing normal, hypothyroid, and hypothyroid-rehabilitated rats. Dev Brain Res 1994;83:151-62.
18. Mackay-Sim, Beard MD. Hypothyroidism disrupts neural development in the olfactory epithelium of adult mice. Dev Brain Res 1987;36:190-8.
19. Deckner ML, Frisen J, Verge VMK, et al. Localization of neurotrophin receptors in olfactory epithelium and bulb. Neuroreport 1993;5:301-4.
20. Clos J, Legand C. An interpretation between thyroid hormone and nerve growth factor promotes the development of hippocampus, olfactory bulb, and cerebellum: a comparative biochemical study of normal and hypothyroid rats. Growth Fact 1990;3:205-20.