Solventless reactions of 5(4H)-oxazolones with umbelliferones and selected enolcarbonyl compounds

Synlett

Volumn , Issue 11, 2003, Pages 1710-1712

  Cordaro, Massimiliano ^a   Di Donna, Leonardo ^b   Foti, Francesco ^a   Grassi, Giovanni ^a   Napoli, Anna ^b   Risitano, Francesco ^a   Sindona, Giovanni ^b  

^a UNIVERSITY OF MESSINA   (Italy)

^b UNIVERSITY OF CALABRIA   (Italy)

Author keywords

Acylation; Chemoselectiviy; Cycloaddition; High resolution ESI spectra; Hydroxycoumarins

Indexed keywords

CARBON; CARBONYL DERIVATIVE; OXAZOLE DERIVATIVE; OXYGEN; SOLVENT; UMBELLIFERONE DERIVATIVE;

ACYLATION; ARTICLE; CHEMOSENSITIVITY; CYCLOADDITION; DECARBOXYLATION; HYDRATION; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE; OXYGENATION; REACTION ANALYSIS; STEREOCHEMISTRY; SYNTHESIS;

EID: 0042280361     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2003-40995     Document Type: Article

References (22)

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21. Typical experimental procedure: Substrate 2 or 4 (2 mmol) and oxazolone 1 (4 mmol) were combined using a mortar and a pestle, and the resulting powder was transferred in a 5 mL sealable glass vial. Under nitrogen atmosphere, the vial was then sealed with a rubber-lined screw cap and teflon tape. After heating for 1 h (disappearance of the starting material by TLC) at 100 °C (or 120 °C), the reaction mixture was cooled at room temperature and purified by crystallization from methanol to afford the indicated product as a white crystalline solid.
22. abstract