The effects of sildenafil citrate (viagra) in the early phase of healing process in open wounds in dogs

Acta Veterinaria Brno

Volumn 72, Issue 2, 2003, Pages 273-277

  Taş, Abuzer ^a,c   Atasoy, N ^b   Ozbek H ^a   Aslan, L ^a   Yuksel H ^a   Ceylan, E ^a   Dagoglu G ^a  

^a YUZUNCU YIL UNIVERSITY   (Turkey)

^b ATATÜRK UNIVERSITY   (Turkey)

^c NONE   (Turkey)

Author keywords

Angiogenesis; Experimental approach; Regeneration; Trauma; Vasodilatation; Vasorelaxation

Indexed keywords

ACETYLCHOLINE; ATROPINE; KETAMINE; NITROPRUSSIDE SODIUM; SILDENAFIL; SODIUM CHLORIDE; XYLAZINE;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRACHIAL ARTERY; CAPILLARY; CELL PROLIFERATION; CONTROLLED STUDY; DISSECTION; DOG; DRUG EFFECT; DRUG SCREENING; EXPERIMENT; FEMALE; FIBROBLAST; GENERAL ANESTHESIA; GRANULATION TISSUE; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PREMEDICATION; SKIN; TISSUE; VASODILATATION; WOUND; WOUND HEALING;

ANIMALIA; CANIS FAMILIARIS;

EID: 0042265685     PISSN: 00017213     EISSN: None     Source Type: Journal    
DOI: 10.2754/avb200372020273     Document Type: Article

References (20)

1. ANONYMOUS 1988: Viagra, Pfizer Inc., USA.
2. BEN EZRA, O 1998: Critical assesment of in vitro and in vivo assays of angiogenesis. In: Maragoudakik M (Ed.): Models, Models and clinical applications. Plenum Press, New York. Pp. 85-89.
3. BROWN, LF, VAN DE WATER, L, HARVEY, VS, DUORAK, HF 1988: Fibrinogen influx and accumulation of cross-linked fibrin in healing wounds and in tumor stroma. Am J Pathol 130: 455-465
4. BUCKLEY, A, DAVIDSON, JM, KAMERATH, CD, WOLT, TB, WOODWARD, SC 1985: Sustained release of epidermal growth factor accelerates wound repair. Proc Natl Acad Sci USA 82: 7340-7344
5. EFRON, DT, MOST, D, SHI, HP, TANTRY, US, BARBUL, A 2001: A novel method of studying wound healing. J Surg Res 98: 16-20
6. FOLKMAN, M, SHING, Y 1992: Angiogenesis. J Biol Chem 267: 10931-10934
7. GOÇMEN, C, SECILMIS, A, UCAR, P, KARATAS, Y, ONDER, S, DIKMEN, A, BAYSAL F 1998: A possible role of S-nitrosothiols at the nitrogenic relaxations in the mouse corpus cavernosum. Eur J Pharmacol 361: 85-92
8. HAKKINEN, L 1990: Fibroblast-bioactive glass interactions. In: YAMAMURO, T, HENCH, HUGHES, SE, HALL, PA 1993: Overview of the fibroblast growth factor and receptor families: complexity, funtional diversity and implications for future cardiovascular research. Cardiovasc Res 27: 1199-1203
9. JONSSON, K, JENSEN, JA, GOODSON, WH, SCHEUENSTUHL, H, WEST, J, HOPF, HW, HUNT, TK 1991: Tissue oxygenation, anemia, and perfusion in relation to wound healing in surgical patients. Ann Surg 214: 605-613
10. KORNOWSKI, R, FUCHS, S, LEON, M, EPSTEIN, SE 2000: Delivery Strategies to achieve therapeutic myocardial angiogenesis. Circulation 101: 454-458
11. LEIBOVICH, SJ, POLVERINI, PJ, FONG, TW, HARLOW, LA, KOCH, AE 1994: Production of angiogenic activity by human monocytes requires an L arginine/nitric oxide-synthase-dependent effector mechanism. Proc Natl Acad Sci USA 91: 4190-4194
12. LYNCH, SE, COLVIN, RB, ANTONIADES, HN 1989: Growth factors in wound healing. J Clin Invest 84: 640-646
13. OKAMOTO, Y, MINAMI, S, MATSUHASHI, A, SASHIWA, H, SAIMOTO, H, SHIGEMASA, Y, TANIGAWA, T, TANAKA, Y, TOKURA, S 1992: Application of chitin and chitosan in small animals. In: SANDFORD, CJ, BRINE, PA, ZIKAKIS, JP (Eds.) Advances in chitin and chitosan. Elsevier Science. New York, pp. 70-78
14. th ed., MD, Williams and Wilkins. USA, pp. 113-158
15. SHI, CC, CHEN, SY, WANG, GJ, LIAO, JF, CHEN, CF 2000: Vasorelaxant effects of harmon. Eur J Pharmacol 390: 319-325
16. STEWART, AG, PHAN, LH, GRIGORIADIS, G 1994: Physiological and pathophysiological roles of nitric oxide. Microsurgery 15: 693-699
17. th Ed. Hatibo?lu Yaymevi, Ankara, pp. 76-86
18. SWAIM, SF, VAUGHN, DM, KINCAID, SA 1996: Effect of locally injected medications on healing of pad wounds in dogs. Am J Vet Res 57: 394-399
19. VAN ROYEN, N, PIEK, JJ, BUSCHMANN, I, HOEFER, I, VOSKUIL, M, SCHAPER, W 2001: Stimulation of arteriogenesis; a new concept for the treatment of arterial occlusive disease. Cardiovascular Res 49: 543-553
20. ZICHE, M, MORBIDELLI, L, MASINI, E, AMERINI, S, GRANGE, HJ, MAGGI, CA 1994: Nitric-oxide mediates angiogenesis in vivo and endothelial cell growth and migration in vitro promoted by substance P. J Clin Invest 94: 2036-2044