Pseudomigraine with lymphocytic pleocytosis: A calcium channelopathy? Clinical description of 10 cases and genetic analysis of the familial hemiplegic migraine gene CACNA1A

Headache

Volumn 43, Issue 8, 2003, Pages 892-895

  Chapman, Kristine M ^a   Szczygielski, Blazej I ^a   Toth, Cory ^c   Woolfenden, Andrew ^a   Robinson, Gordon ^a   Snutch, Terrance P ^a   Spacey, Siân D ^a,b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c NONE

Author keywords

CACNA1A gene; Headache; Headache with neurologic deficits and cerebrospinal fluid lymphocytosis (HaNDL); Pseudomigraine with lymphocytic pleocytosis (PMP)

Indexed keywords

CALCIUM CHANNEL;

ADULT; APHASIA; ARTICLE; BLOOD SAMPLING; CACNA1A GENE; CLINICAL ARTICLE; CLINICAL FEATURE; CONFUSION; DNA DETERMINATION; DNA SEQUENCE; FAMILIAL DISEASE; FEMALE; GENE; GENE MUTATION; GENETIC ANALYSIS; HEADACHE; HETERODUPLEX ANALYSIS; HUMAN; MALE; MUSCLE WEAKNESS; PRIORITY JOURNAL; PSEUDOMIGRAINE WITH LYMPHOCYTIC PLEOCYTOSIS; RETROSPECTIVE STUDY; SENSORY DYSFUNCTION; VISUAL DISORDER;

ADULT; CALCIUM CHANNELS; FEMALE; HEADACHE; HUMANS; LYMPHOCYTE COUNT; LYMPHOCYTOSIS; MALE; MIDDLE AGED; MIGRAINE WITH AURA; MUTATION; NERVOUS SYSTEM DISEASES; POLYMORPHISM, GENETIC; RECURRENCE; RETROSPECTIVE STUDIES;

EID: 0042237022     PISSN: 00178748     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1526-4610.2003.03168.x     Document Type: Article

References (15)

1. Bartleson JD, Swanson JW, Whisnant JP. A migrainous syndrome with cerebrospinal fluid pleocytosis. Neurology. 1981;311:1257-1262.
2. Berg MJ, Williams LS. The transient syndrome of headache with neurologic deficits and CSF pleocytosis. Neurology. 1995;45:1648-1654.
3. Gomez-Aranda F, Canadillas F, Marti-Masso J, et al. Pseudomigraine with temporary neurological symptoms and lymphocytic pleocytosis: a report of 50 cases. Brain. 1997;120:1105-1113.
4. Spelsberg B, Willert C, Machetanz J. Pseudomigraine with pleocytosis. Nervenarzt. 2001;72:791-793.
5. Fuentes B, Diez Tejedor E, Pascual J, Coya J, Quirce R. Cerebral blood flow changes in pseudomigraine with pleocytosis analyzed by single photon emission computed tomography. A spreading depression mechanism? Cephalalgia. 1998;18:570-573.
6. Fuentes B, Diez Tejedor E, Frank A. Syndrome of headache with neurological deficits and CSF lymphocytosis: a spreading depression mechanism? The role of SPECT [letter]. Headache. 1998;38:324.
7. Caminero AB, Pareja JA, Arpa J, Vivancos F, Palomo F, Coya J. Migrainous syndrome with CSF pleocytosis. SPECT findings. Headache. 1997;37:511-515.
8. Ducros A, Denier C, Joutel A, et al. The clinical spectrum of Familial Hemiplegic Migraine associated with mutations in a neuronal calcium channel. N Engl J Med. 2001;345:17-24.
9. Terwindt G, Kors E, Haan J, et al. Mutation analysis of the CACNA1A calcium channel subunit gene in 27 patients with sporadic hemiplegic migraine. Arch Neurol. 2002;59:1016-1018.
10. Vahedi K, Denier C, Ducros A. CACNA1A gene de novo mutation causing hemiplegic migraine, coma, and cerebellar atrophy. Neurology. 2000;55:1040-1042.
11. Ophoff RA, Terwindt GM, Vergouwe MN, et al. Familial hemiplegic migraine and episodic ataxia type-2 are caused by mutations in the Ca2+ channel gene CACNL1A4. Cell. 1996;87:543-552.
12. Battistini S, Stenirri S, Piatti M, et al. A new CACNA1A gene mutation in acetazolamide-responsive familial hemiplegic migraine and ataxia. Neurology. 1999;53:38-43.
13. Friend KL, Crimmins D, Phan TG, et al. Detection of a novel missense mutation and second recurrent mutation in the CACNA1A gene in individuals with EA-2 and FHM. Hum Genet. 1999;105:261-265.
14. Carrera P, Piatti M, Stenirri S, et al. Genetic heterogeneity in Italian families with familial hemiplegic migraine. Neurology. 1999;53:26-33.
15. Kors E, Terwindt GM, Vermeulen FL, et al. Delayed cerebral edema and fatal coma after minor head trauma: role of the CACNA1A calcium channel subunit gene and relationship with familial hemiplegic migraine. Ann Neurol. 2001;49:753-760.