A Kinetic Analysis of γ-Aminobutyrate Aminotransferase in Presence and Absence of Inhibitors

Berichte der Bunsengesellschaft/Physical Chemistry Chemical Physics

Volumn 100, Issue 5, 1996, Pages 671-679

  Porcelli, Fernando ^a   Scibona, Gianearlo ^b   Boire, Francesco ^b   Lorenti, Giampiero ^a   Mazzel, Franco ^b   Botrè, Claudio ^a  

^a UNIVERSITY OF TUSCIA   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Biophysical Chemistry; Catalysis; Chemical Kinetics; Enzyme Inhibition; GABA Trcmsaminase

Indexed keywords

EID: 0042200559     PISSN: 0940483X     EISSN: None     Source Type: Journal    
DOI: 10.1002/bbpc.19961000520     Document Type: Article

References (16)

1. E. M. Scott and W.B. Jakoby, J. Biol. Chem. 234, 932-936 (1959).
2. J.R. Burke and R.B. Silverman, J. Am. Chem. Soc. 113, 9329-9340 (1991).
3. S.VI. Nanavati and R.B. Silverman, j. Am. Chem. Soc. 113, 9341-9349 (1991).
4. S.F. Velick and J. Vavra, J. Biol. Chem. 237, 2109-2122 (1962).
5. W.B. Jakoby, Methods Enzymol. V, 765-778 (1962).
6. G. Cassel. L. Karlsson, and A. Seilstrom, Pharmacol. Toxicol. 69, 238-242 (1991).
7. M. Maître, L. Ciesielski, and P. Mandel, Biochem. Pharmacol. 23. 2363-2368 (1974).
8. L.J. Fowler, J. Beckford, and R.A. John, Biochem. Pharmacol. 24. 1267- 1270 (1975).
9. R.B. Silverman and C. George, Biochemistry 27, 3285-3289 (1988).
10. G. Scibona and F. Botrè, Italian Patent, Appl. No. M192-A-000527, 1992.
11. C. Botrè, F. Botrè, G. Lorenti, F. Mazzei, F. Porcelli, and G. Scibona, Can. J. Physioi. Pharmacol. 72, 340 (1994).
12. O.M. Larsson, L. Gram, 1. Schousboe, and A. Schousboe, Neuropharmacology 25, 617-625 (1986).
13. M. Larsson and A. Schousboe, Neurochem. Res. 15, 1073-1077 (1990).
14. J.L. Fowler, H. D. Loveil, and R.A. John, J. Neurochem. 41, 1751- 1754 (1983).
15. E.M. Scott and W.B. Jakoby, J. Biol. Chem. 234, 937-940 (1959).
16. M. W. Nkenberg and W. B. Jakoby, J. Biol. Chem. 235, 954 - 960 (1960).