Fibrosis and inflammatory activity in noncancerous tissue and mitotic index of cancer tissue in patients with hepatocellular carcinoma: Relationship to clinicopathological factors and prognosis after hepatic resection

Digestive Diseases and Sciences

Volumn 48, Issue 8, 2003, Pages 1517-1522

  Nanashima, Atsushi ^a   Tanaka, Kenji ^a   Yamaguchi, Hiroyuki ^a   Shibasaki, Shinichi ^a   Morino, Shigeyuki ^a   Yoshinaga, Megumi ^a   Sawai, Terumitsu ^a   Nakagoe, Tohru ^a   Ayabe, Hiroyoshi ^a  

^a NAGASAKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Grading; HAI; Hepatic resection; Hepatocellular carcinoma; Mitotic index; Staging

Indexed keywords

ADULT; AGED; ARTICLE; CANCER GRADING; CANCER INCIDENCE; CANCER INVASION; CANCER PATIENT; CANCER RECURRENCE; CANCER RISK; CANCER SURVIVAL; CARCINOMA IN SITU; CELL DIFFERENTIATION; CHRONIC HEPATITIS; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; DISEASE MARKER; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER DYSFUNCTION; LIVER FIBROSIS; LIVER RESECTION; MAJOR CLINICAL STUDY; MALE; MITOSIS INDEX; MULTIVARIATE ANALYSIS; POSTOPERATIVE COMPLICATION; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; RECURRENCE RISK; SURVIVAL TIME; TUMOR RECURRENCE;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, HEPATOCELLULAR; CHEMOEMBOLIZATION, THERAPEUTIC; FEMALE; FLUOROURACIL; HEPATECTOMY; HEPATITIS B; HEPATITIS C; HUMANS; LIVER; LIVER CIRRHOSIS; LIVER NEOPLASMS; MALE; MATHEMATICAL COMPUTING; MIDDLE AGED; MITOTIC INDEX; NEOADJUVANT THERAPY; NEOPLASM STAGING; PROGNOSIS; RISK; SURVIVAL RATE;

EID: 0042200505     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1024759606402     Document Type: Article

References (42)

1. Liver Cancer Study Group of Japan: Predictive factors for long-term prognosis after partial hepatectomy for patients with hepatocellular carcinoma in Japan. Cancer 74:2772-2780, 1994
2. Poon RT, Ng IO, Fan ST, Lai EC, Lo CM, Liu CL, Wong J: Clinicopathologic features of long-term survivors and disease-free survivors after resection of hepatocellular carcinoma: a study of a prospective cohort. J Clin Oncol 19:3037-3044, 2001
3. Hirohashi K, Shuto T, Kubo S, Tanaka H, Yamamoto T, Ikebe T, Murase J, Kinoshita H: Prognostic factors after recurrence of resected hepatocellular carcinoma associated with hepatitis C virus. J Hepatobiliary Pancreat Surg 8:81-86, 2001
4. Terris B, Laurent-Puig P, Belghitti J, Degott C, Henin D, Flejou JF: Prognostic influence of clinicopathologic features, DNA-ploidy, CD44H and p53 expression in a large series of resected hepatocellular carcinoma in France. Int J Cancer 74:614-619, 1997
5. Liver Cancer Study Group of Japan: The General Rules for the Clinical and Pathological Study of Primary Liver Cancer, 4th Kanehara & Co., Tokyo, ed. 2000, pp 11-34
6. Yamamoto J, Okada S, Shimada K, Okusaka T, Yamasaki S, Ueno H, Kosuge T: Treatment strategy for small hepatocellular carcinoma: comparison of long-term results after percutaneous ethanol injection therapy and surgical resection. Hepatology 34:707-714, 2001
7. Adachi E, Maeda T, Matsumata T, Shirabe K, Kinukawa N, Sugimachi K, Tsuneyoshi M: Risk factors for intrahepatic recurrence in human small hepatocellular carcinoma. Gastroenterology 108:768-775, 1995
8. Nakashima O, Kojiro M: Recurrence of hepatocellular carcinoma: multicentric occurrence or intrahepatic metastasis? A viewpoint in terms of pathology. J Hepatobiliary Pancreat Surg 8:404-409, 2001
9. Ko S, Kanehiro H, Hisanaga M, Nagao M, Ikeda N, Nakajima Y: Liver fibrosis increases the risk of intrahepatic recurrence after hepatectomy for hepatocellular carcinoma. Br J Surg 89:57-62, 2002
10. Ko S, Nakajima Y, Kanehiro H, Hisanaga M, Aomatsu Y, Kin T, Yagura K, Ohyama T, Nishio K, Ohashi K, Sho M, Yamada T, Nakano H: Significant influence of accompanying chronic hepatitis status on recurrence of hepatocellular carcinoma after hepatectomy. Result of multivariate analysis. Ann Surg 224:591-595, 1996
11. Takata M, Yamanaka N, Tanaka T, Yamanaka J, Maeda S, Okamoto E, Yasojima H, Uematsu K, Watanabe H, Uragari Y: What patients can survive disease free after complete resection for hepatocellular carcinoma? A multivariate analysis. Jpn J Clin Oncol 30:75-81, 2000
12. Matsumoto K, Yoshimoto J, Sugo H, Kojima K, Futagawa S, Matsumoto T: Relationship between the histological degrees of hepatitis and the postoperative recurrence of hepatocellular carcinoma in patients with hepatitis C. Hepatol Res 23:196-201, 2002
13. Knodell RG, Ishak KG, Black WC: Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology 1:431-435, 1981
14. Desmet VJ, Gerber M, Hoofnagle JH: Classification of chronic hepatitis: diagnosis, grading and staging. Hepatology 19:1513-1520, 1994
15. Ebelt J, Neid M, Tannapfel A, Witzigmann H, Hauss J, Kockerling F, Wittekind C: Prognostic significance of proliferation markers in hepatocellular carcinoma (HCC) Zentralbl Chir 125:597-601, 2000 (in German with English abstract)
16. Ouchi K, Sugawara T, Ono H, Fujiya T, Kamiyama Y, Kakugawa Y, Mikuni J, Yamanami H, Komatsu S, Horikoshi A: Mitotic index is the best predictive factor for survival of patients with resected hepatocellular carcinoma. Dig Surg 17:42-48, 2000
17. Nagao T, Kondo F, Sato T, Nagato Y, Kondo Y: Immunohistochemical detection of aberrant p53 expression in hepatocellular carcinoma: correlation with cell proliferative activity indices, including mitotic index and MIB-1 immunostaining. Hum Pathol 26:326-333, 1995
18. Garcia S, Martini F, De Micco C, Andrac L, Hardwigsen J, Sappa P, Lavaut MN, Le Treut YP, Charpin C: Immunoexpression of E-cadherin and beta-catenin correlates to survival of patients with hepatocellular carcinomas. Int J Oncol 12:443-447, 1998
19. Tannapfel A, Geissler F, Kockerling F, Katalinic A, Hauss J, Wittekind C: Apoptosis and proliferation in relation to histopathological variables and prognosis in hepatocellular carcinoma. J Pathol 187:439-445, 1999
20. Shimada M, Rikimaru T, Hamatsu T, Yamashita Y, Terashi T, Taguchi K, Tanaka S, Shirabe K, Sugimachi K: The role of macroscopic classification in nodular-type hepatocellular carcinoma. Am J Surg 182:177-182, 2001
21. Ichida F, Tsuji T, Omata M, Ichida T, Inoue K, Kamimura T, Yamada G, Hino K, Yokosuka O, Suzuki H: New Inuyama classification for histological assessment of chronic hepatitis. Hepatol Commun 6:112-119, 1996
22. Haratake J, Takeda S, Kasai T, Nakano S, Tokui N: Predictable factors for estimating prognosis of patients after resection of hepatocellular carcinoma. Cancer 72:1178-1183, 1993
23. Adachi E, Maeda T, Matsumata T, Shirabe K, Kinukawa N, Sugimachi K, Tsuneyoshi M: Risk factors for intrahepatic recurrence in human small hepatocellular carcinoma. Gastroenterology 108:768-775, 1995
24. Matsumoto K, Yoshimoto J, Sugo H, Kojima K, Futagawa S, Matsumoto T: Relationship between the histological degrees of hepatitis and the postoperative recurrence of hepatocellular carcinoma in patients with hepatitis C. Hepatol Res 23:196-201, 2002
25. Sakaida I, Hironaka K, Okita K: Fibrosis accelerates the development of enzyme-altered lesions in the rat liver. Hepatology 28:1247-1252, 1998
26. Yamanaka N, Takada M, Tanaka T, Yamanaka J, Yasui C, Ando T, Maeda S, Matsushita K, Okamoto E: Viral serostatus and coexisting inflammatory activity affect metachronous carcinogenesis after hepatectomy for hepatocellular carcinoma. J Gastroenterol 35:206-213, 2000
27. Kubo S, Yamamoto T, Ikebe T, Shuto T, Hirohashi K, Tanaka H, Tsukamoto T, Wakasa K, Kinoshita H: Relationship between multicentric occurrence of hepatocellular carcinoma and histology of noncancerous hepatic tissue in patients with chronic hepatitis C. Jpn J Cancer Res 90:1076-1080, 1999
28. Hadziyannis SJ: Why and how to treat chronic hepatitis C. Can J Gastroenterol 14(suppl B):45B-48B, 2000
29. Sohda T, Iwata K, Tsutsu N, Kamimura S, Shijo H, Sakisaka S: Increased expression of transforming growth factor-alpha in a patient with recurrent hepatocellular carcinoma following partial hepatectomy. Pathology 33:511-514, 2001
30. Nagata K, Hirono S, Ido A, Kataoka H, Moriuchi A, Shimomura T, Hori T, Hayashi K, Koono M, Kitamura N, Tsubouchi H: Expression of hepatocyte growth factor activator and hepatocyte growth factor activator inhibitor type 1 in human hepatocellular carcinoma. Biochem Biophys Res Commun 289:205-211, 2001
31. Shi B, Wang X, Yang Z: Vascular endothelial growth factors and liver diseases. Hepatogastroenterology 48:1145-1148, 2001
32. Thung SN, Hytiroglou P, Fiel I, Theise N: Preneoplastic lesions in chronic hepatitis C. Princess Takamatsu Symp 25:171-178, 1995
33. Ko S, Nakajima Y, Kanehiro H, Kin T, Aomatsu Y, Yoshimura A, Taki J, Yagura K, Ohashi K, Nakano H: Influence of associated viral hepatitis status on recurrence of hepatocellular carcinoma after hepatectomy. World J Surg 20:1082-1086, 1996
34. Maeda T, Adachi E, Kajiyama K, Takenaka K, Sugimachi K, Tsuneyoshi M: Proliferative activity in intrahepatic metastasis of hepatocellular carcinoma. J Gastroenterol Hepatol 11:752-757, 1996
35. Ouchi K, Sugawara T, Ono H, Fujiya T, Kamiyama Y, Kakugawa Y, Mikuni J, Yamanami H, Komatsu S, Horikoshi A: Mitotic index is the best predictive factor for survival of patients with resected hepatocellular carcinoma. Dig Surg 17:42-48, 2000
36. Jaskiewicz K, Banach L, Lancaster E: Hepatic siderosis, fibrosis and cirrhosis: the association with hepatocellular carcinoma in high-risk population. Anticancer Res 17:3897-3899, 1997
37. Koike Y, Shiratori Y, Sato S, Obi S, Teratani T, Imamura M, Hamamura K, Imai Y, Yoshida H, Shiina S, Omata M: Risk factors for recurring hepatocellular carcinoma differ according to infected hepatitis virus - an analysis of 236 consecutive patients with a single lesion. Hepatology 32:1216-1223, 2000
38. Nakashima O, Kojiro M: Recurrence of hepatocellular carcinoma: multicentric occurrence or intrahepatic metastasis? A viewpoint in terms of pathology. J Hepatobiliary Pancreat Surg 8:404-409, 2001
39. Miyaguchi S, Watanabe T, Takahashi H, Nakamura M, Saito H, Ishii H: Interferon therapy for hepatocellular carcinoma patients with low HCV-RNA levels. Hepatogastroenterology 49:724-729, 2002
40. Pramoolsinsup C: Management of viral hepatitis B. J Gastroenterol Hepatol 17 (suppl 1):125-145, 2002
41. Walsh K, Alexander GJ: Update on chronic viral hepatitis. Postgrad Med J 77:498-505, 2001
42. Chayama K: Management of chronic hepatitis C and prevention of hepatocellular carcinoma. J Gastroenterol 37 (suppl 13):69-73, 2002