A high frequency of allergen-specific CD8+ Tc1 cells is associated with the murine immune response to the contact sensitizer trinitrophenyl

Experimental Dermatology

Volumn 12, Issue 1, 2003, Pages 78-85

  Martin, Stefan ^a   Delattre, Virginie ^a   Leicht, Cornelia ^a   Weltzien, Hans Ulrich ^b   Simon, Jan C ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

Author keywords

Allergy; Cytotoxicity; Dendritic cell; Hapten; Rodent

Indexed keywords

HAPTEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PEPTIDE; TRINITROPHENYL;

ALLERGIC REACTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL MEDIATED CYTOTOXICITY; CELLULAR IMMUNITY; CONTACT ALLERGY; CONTACT SENSITIZATION; CONTROLLED STUDY; CORRELATION ANALYSIS; EFFECTOR CELL; IMMUNE RESPONSE; LYMPHOID ORGAN; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PROTEIN BINDING; T LYMPHOCYTE;

ALLERGENS; ANIMALS; ANTIBODY FORMATION; CD8-POSITIVE T-LYMPHOCYTES; DENDRITIC CELLS; DERMATITIS, CONTACT; IMMUNIZATION; INTERFERON TYPE II; MICE; MICE, INBRED C57BL; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES, CYTOTOXIC; T-LYMPHOCYTES, REGULATORY; TRINITROBENZENES;

EID: 0042173007     PISSN: 09066705     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0625.2003.120110.x     Document Type: Article

References (21)

1. Martin S, Weltzien H U. T cell recognition of haptens, a molecular view. Int Arch Allergy Immunol 1994: 104: 10-16.
2. Weltzien H U, Moulon C, Martin S, Padovan E, Hartmann U, Kohler J. T-cell immune responses to haptens - Structural models for allergic and autoimmune reactions. Toxicology 1996: 107: 141-151.
3. + T cells are the dominant effector cells in trinitrophenyl-specific contact hypersensitivity. J Invest Dermatol 2000: 115: 260-266.
4. Taguchi T, McGhee J R, Coffman R L et al. Detection of individual mouse splenic T cells producing IFN-gamma and IL-5 using the enzyme-linked immunospot (ELISPOT) assay. J Immunol Methods 1990: 128: 65-73.
5. Miyahira Y, Murata K, Rodriguez D et al. Quantification of antigen specific CD8+ T cells using an ELISPOT assay. J Immunol Methods 1995: 181: 45-54.
6. Martin S, Ortmann B, Pflugfelder U, Birsner U, Weltzien H U. Role of hapten-anchoring peptides in defining hapten-epitopes for MHC-restricted cytotoxic T cells. Crossreactive TNP-determinants on different peptides. J Immunol 1992: 149: 2569-2575.
7. b-restricted TNP epitopes. J Immunol 1993: 151: 678-687.
8. - dendritic cells induce hapten-specific immune responses in vitro and in vivo. J Invest Dermatol 1997: 109: 580-585.
9. Krasteva M, Kehren J, Horand F et al. Dual role of dendritic cells in the induction and down-regulation of antigen-specific cutaneous inflammation. J Immunol 1998: 160: 1181-1190.
10. Lappin M B, Weiss J M, Delattre V et al. Analysis of mouse dendritic cell migration in vivo upon subcutaneous and intravenous injection. Immunology 1999: 98: 181-188.
11. Martin S, Ruh H, Hebbelmann S, Pflugfelder U, Rüde B, Weltzien H U. Carrier-reactive hapten-specific cytotoxic T lymphocyte clones originate from a highly preselected T cell repertoire: Implications for chemical-induced self-reactivity. Eur J Immunol 1995: 25: 2788-2796.
12. Mauri-Hellweg D, Zanni M, Frei E et al. Cross-activity of T cell lines and clones to beta-lactam antibiotics. J Immunol 1996: 157: 1071-1079.
13. Vollmer J, Fritz M, Dormoy A, Weltzien H U, Moulon C. Dominance of the BV17 element in nickel-specific human T cell receptors relates to severity of contact sensitivity. Eur J Immunol 1997: 27: 1865-1874.
14. + T cells, respectively, mediate and regulate contact sensitivity to dinitrofluorobenzene. Eur J Immunol 1995: 25: 3006-3010.
15. + T-cells. J Exp Med 1996: 183: 1001-1012.
16. Pior J, Vogl T, Sorg C, Macher E. Free hapten molecules are dispersed by way of the bloodstream during contact sensitization to fluorescein isothiocyanate. J Invest Dermatol 1999: 113: 888-893.
17. Kohler J, Martin S, Pflugfelder U, Ruh H, Vollmer J, Weltzien H U. Cross-reactive trinitrophenylated peptides as antigens for class-II major histocompatibility complex-restricted T-cells and inducers of contact hypersensitivity in mice - Limited T-cell receptor repertoire. Eur J Immunol 1995: 25: 92-101.
18. Kohler J, Hartmann U, Grimm R, Pflugfelder U, Weltzien H U. Carrier-independent hapten recognition and promiscuous MHC restriction by CD4 T cells induced by trinitrophenylated peptides. J Immunol 1997: 158: 591-597.
19. Garboczi D N, Biddison W E. Shapes of MHC restriction. Immunity 1999: 10: 1-7.
20. Garcia K C, Teyton L, Wilson I A. Structural basis of T cell recognition. Annu Rev Immunol 1999: 17: 369-397.
21. Steinbrink K, Sorg C, Macher E. Low zone tolerance to contact allergens in mice: A functional role for CD8+ T helper type 2 cells. J Exp Med 1996: 183: 759-768.