Biochemical and pharmacokinetic evaluation of a novel pyrimidine nucleoside nitric oxide donor as a potential anticancer/antiviral agent

European Journal of Pharmaceutical Sciences

Volumn 19, Issue 4, 2003, Pages 305-313

  Khalili, Panteha ^a   Naimi, Ebrahim ^a   Sun, Wei Yan ^a   Knaus, Edward E ^a   Wiebe, Leonard I ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

3 Nitrooxy pyrimidine nucleoside; Biliary excretion; Glucuronide metabolites; IUdR; NO donor; Thymidine phosphorylase

Indexed keywords

BIOCHEMISTRY; NITROGEN COMPOUNDS; PHARMACOKINETICS; PHOSPHATES; PROTEINS; TUMORS; ULTRAFILTRATION;

PHOSPHOROLYSIS;

DRUG PRODUCTS;

3' O NITRO 2' DEOXYTHYMIDINE; 5 IODO 3' O NITRO 2' DEOXYURIDINE; ANTINEOPLASTIC AGENT; ANTIVIRUS AGENT; BOVINE SERUM ALBUMIN; BUFFER; CYSTEINE; GLUTATHIONE; IDOXURIDINE; ISOSORBIDE DINITRATE; NITRIC OXIDE DONOR; PHOSPHATE; PYRIMIDINE NUCLEOSIDE; THYMIDINE DERIVATIVE; THYMIDINE PHOSPHORYLASE; UNCLASSIFIED DRUG; WATER;

ANIMAL EXPERIMENT; ARTICLE; BIOCHEMISTRY; CALCULATION; CATABOLISM; CATALYSIS; COMPUTER PROGRAM; CONTROLLED STUDY; DEPHOSPHORYLATION; DRUG BINDING; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG IDENTIFICATION; DRUG RELEASE; DRUG STABILITY; DRUG STRUCTURE; ENVIRONMENTAL TEMPERATURE; IN VITRO STUDY; LIPOPHILICITY; MALE; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN BINDING; RAT; STEADY STATE; ULTRAFILTRATION;

EID: 0042168656     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-0987(03)00132-5     Document Type: Article

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