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1
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0008210890
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Shire focuses on virtual integration
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174166 Shire focuses on virtual integration. Scrip 1995 2006 12
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Scrip
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2
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0041996367
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Major achievements by Shire in its tenth anniversary year. Four projects advanced to the next development phase
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220712; September 27
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220712 Major achievements by Shire in its tenth anniversary year. Four projects advanced to the next development phase. Shire Pharmaceuticals Ltd Press Release 1996 September 27
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(1996)
Shire Pharmaceuticals Ltd Press Release
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3
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0008177591
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Shire to enter phase II studies with Lambda
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240183; March 21
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240183 Shire to enter phase II studies with Lambda. Shire Pharmaceuticals Ltd Press Release 1997 March 21
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(1997)
Shire Pharmaceuticals Ltd Press Release
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-
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4
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0041495341
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Shire Pharmaceuticals Group plc: Excellent commercial and research and development progress
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245004; May 06
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245004 Shire Pharmaceuticals Group plc: Excellent commercial and research and development progress. Shire Pharmaceuticals Group Plc Press Release 1997 May 06
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(1997)
Shire Pharmaceuticals Group Plc Press Release
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-
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5
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0008211805
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Shire's prospects for chronic fatigue syndrome and renal bone disorder
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246389
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246389 Shire's prospects for chronic fatigue syndrome and renal bone disorder. IDdb author IDDB Meeting Report 1997 May 06
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IDDB Meeting Report 1997 May 06
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6
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0000647629
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Lanthanum carbonate: A novel non-calcium containing phosphate binder
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302062; Abs 560A; note
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302062 Lanthanum carbonate: A novel non-calcium containing phosphate binder. Dewberry K, Fox JS, Stewart J, Murray JR, Hutchison AJ J Am Soc Nephrol 1997 9 Abs 560A Phase I study demonstrating the efficacy of lanthanum carbonate, as compared to placebo, in reducing urinary phosphorus excretion in healthy volunteers, indicating effective intestinal phosphate binding.
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J Am Soc Nephrol
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Dewberry, K.1
Fox, J.S.2
Stewart, J.3
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Hutchison, A.J.5
-
7
-
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0002390572
-
Lanthanum carbonate an effective inhibitor of phosphate absorption from the intestinal tract
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302064; note
-
302064 Lanthanum carbonate an effective inhibitor of phosphate absorption from the intestinal tract. Dewberry K, Fox JS, Curtis CG, Murray JR, Hutchinson AJ Nephrol Dial Transplant 1997 12 9 A98 Experimental study showing the efficacy of lanthanum carbonate in reducing radiolabeled intestinal absorption in isolation perfused gut of rats.
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Nephrol Dial Transplant
, vol.12
, Issue.9
-
-
Dewberry, K.1
Fox, J.S.2
Curtis, C.G.3
Murray, J.R.4
Hutchinson, A.J.5
-
8
-
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0008212351
-
Shire Pharmaceuticals Group plc reports STG 6.2 million profit for the nine months ended September 1998
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304751; November 11
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304751 Shire Pharmaceuticals Group plc reports STG 6.2 million profit for the nine months ended September 1998. Shire Pharmaceuticals Group Plc Press Release 1998 November 11
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(1998)
Shire Pharmaceuticals Group Plc Press Release
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-
-
9
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0008214321
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Shire reports positive US phase II results for Lambda
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329228; June 24
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329228 Shire reports positive US phase II results for Lambda. Shire Pharmaceuticals Group Plc Press Release 1999 June 24
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(1999)
Shire Pharmaceuticals Group Plc Press Release
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-
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10
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0008217750
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AnorMED's drug Lambda will proceed to phase III in US after positive phase II results with kidney failure patients
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329493; June 25
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329493 AnorMED's drug Lambda will proceed to phase III in US after positive phase II results with kidney failure patients. AnorMED Inc Press Release 1999 June 25
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(1999)
AnorMED Inc Press Release
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11
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0033398022
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Calcitriol, lanthanum carbonate, and other new phosphate binders in the management of renal osteodystrophy
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360624; note
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360624 Calcitriol, lanthanum carbonate, and other new phosphate binders in the management of renal osteodystrophy. Hutchinson AJ Perit Dial Int 1999 19 Suppl 2 S408-S412 A good review of the treatment of renal osteodystrophy, focusing on new phosphate binders, lanthanum carbonate and Renagel.
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Perit Dial Int
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Hutchinson, A.J.1
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12
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0033377039
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Phosphate binders on iron basis: A new perspective?
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360626
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360626 Phosphate binders on iron basis: A new perspective? Kidney Int Suppl 1999 73 S42-S45
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Kidney Int Suppl
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Hergessell, O.1
Ritz, E.2
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13
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Safety of an investigational phosphate binder (lanthanum carbonate) in hemodialysis patients
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360635
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360635 Safety of an investigational phosphate binder (lanthanum carbonate) in hemodialysis patients. Joy MS, Hladik GA, Finn WF J Am Soc Nephrol 1999 10 263A
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(1999)
J Am Soc Nephrol
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Joy, M.S.1
Hladik, G.A.2
Finn, W.F.3
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14
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0000850920
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Results of a randomized dose-ranging, placebo cotrolled study of lanthanum carbonate for reduction of serum phosphate in chronic renal failure patients receiving hemodialysis
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360637; note
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360637 Results of a randomized dose-ranging, placebo cotrolled study of lanthanum carbonate for reduction of serum phosphate in chronic renal failure patients receiving hemodialysis. Finn WF, Joy MS, Hladik GA J Am Soc Nephrol 1999 10 261A Lanthanum carbonate efficacy in a phase II study conducted in 145 hemodialysis patients.
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(1999)
J Am Soc Nephrol
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Finn, W.F.1
Joy, M.S.2
Hladik, G.A.3
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15
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0032805581
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Hyperphosphatemia - A silent killer of patients with renal failure
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366779
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366779 Hyperphosphatemia - A silent killer of patients with renal failure. Amann K, Gross ML, London GM, Ritz E Nephrol Dial Transplant 1999 14 9 2085-2087
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Nephrol Dial Transplant
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Amann, K.1
Gross, M.L.2
London, G.M.3
Ritz, E.4
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16
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0031920748
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Association of serum phosphorus and calcium × phosphate product with mortality risk in chronic hemodialysis patients: A national study
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366782; note
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366782 Association of serum phosphorus and calcium × phosphate product with mortality risk in chronic hemodialysis patients: A national study. Block GA, Hulbert-Sheron TE, Levin NW, Port FK Am J Kidney Dis 1998 31 4 607-617 An important clinical study directly linking hyperphosphatemia and increased Ca-P product to mortality in hemodialysis patients.
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(1998)
Am J Kidney Dis
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Block, G.A.1
Hulbert-Sheron, T.E.2
Levin, N.W.3
Port, F.K.4
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17
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0018754598
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Fracturing dialysis osteodystrophy and dialysis encephalopathy
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366783; note
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366783 Fracturing dialysis osteodystrophy and dialysis encephalopathy. Parkinson IS, Ward MK, Feest RWP, Kerr DNS 1979 1 8113 406-409 Highlights the risk of long-term aluminium toxicity in dialysis patients, due to use of dialysate containing aluminium (even at very low concentrations).
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Lancet
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Parkinson, I.S.1
Ward, M.K.2
Feest, R.W.P.3
Kerr, D.N.S.4
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18
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0024501071
-
Reduction of dietary phosphorus absorption by phosphorus binders
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366784; note
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366784 Reduction of dietary phosphorus absorption by phosphorus binders. Sheikh MS, Maguire JA, Emmett M, Santa Ana CA, Nicar MJ, Schiller LR, Fordtran JS J Clin Invest 1989 81 1 66-73 A review of phosphate binders, highlighting the risk of hypercalcemia due to calcium-containing phosphate binders.
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(1989)
J Clin Invest
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Sheikh, M.S.1
Maguire, J.A.2
Emmett, M.3
Santa Ana, C.A.4
Nicar, M.J.5
Schiller, L.R.6
Fordtran, J.S.7
-
19
-
-
0032614383
-
Renagel, a nonabsorbed calcium- and aluminium-free phosphate binder, lowers serum phosphorus and parathyroid hormone. The Renagel Study Group
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366786
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366786 Renagel, a nonabsorbed calcium- and aluminium-free phosphate binder, lowers serum phosphorus and parathyroid hormone. The Renagel Study Group. Slatopolsky EA, Burke SK, Dillon MA Kidney Int 1999 55 1 299-307
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(1999)
Kidney Int
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Slatopolsky, E.A.1
Burke, S.K.2
Dillon, M.A.3
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20
-
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0029147268
-
A possible non-aluminum oral phosphate binder? A comparative study on dietary phosphorus absorption
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366788; note
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366788 A possible non-aluminum oral phosphate binder? A comparative study on dietary phosphorus absorption. Graff L, Burnel D Res Comm Mol Pathol Pharmacol 1995 90 3 373-388 Study conducted in rats demonstrating the efficacy of lanthanum chloride as an intestinal phosphate binder.
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Res Comm Mol Pathol Pharmacol
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Graff, L.1
Burnel, D.2
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21
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0008255480
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Lanthanum carbobate: A novel non-calcium containing phosphate binder in CAPD patients
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366789
-
366789 Lanthanum carbobate: A novel non-calcium containing phosphate binder in CAPD patients. Hutchinson AJ, Speake M, Dewberry K, Fox JS Perit Dial Int 1998 18 S38
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(1998)
Perit Dial Int
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Hutchinson, A.J.1
Speake, M.2
Dewberry, K.3
Fox, J.S.4
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22
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0026352606
-
Combined report on regular dialysis and transplantation in Europe, XX, 1989
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366791; note
-
366791 Combined report on regular dialysis and transplantation in Europe, XX, 1989. Fassbinder W, Brunner FP, Brynger H, Ehrich JH, Geerlings W, Raine AE, Rizzoni G, Selwood NH, Tufveson G, Wing AJ Nephrol Dial Transplant 1991 6 Suppl 1 5-35 Provides data on the effects of parathyroidectomy during the late 1980s, reportig no improvement in medical control of secondary hyperparathyroidism in chronic renal failure.
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(1991)
Nephrol Dial Transplant
, vol.6
, Issue.SUPPL. 1
, pp. 5-35
-
-
Fassbinder, W.1
Brunner, F.P.2
Brynger, H.3
Ehrich, J.H.4
Geerlings, W.5
Raine, A.E.6
Rizzoni, G.7
Selwood, N.H.8
Tufveson, G.9
Wing, A.J.10
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23
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0032944582
-
A comparison of the calcium-free phosphate binder sevelamer hydrochloride with calcium acetate in the treatment of hyperphosphatemia in hemodialysis patients
-
382415; [see comments]; note
-
382415 A comparison of the calcium-free phosphate binder sevelamer hydrochloride with calcium acetate in the treatment of hyperphosphatemia in hemodialysis patients [see comments]. Bleyer AJ, Burke SK, Dillon M, Garrett B, Kant KS, Lynch D, Rahman SN, Schoenfeld P, Teitelbaum I, Zeig S, Slatopolsky E Am J Kidney Dis 1999 33 4 694-701 Phase III trial demostrating the similar phosphate-lowering capacity of sevelamer and calcium acetate, although significantly lower hypercalcemic episodes in patients treated with sevelamer is reported.
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(1999)
Am J Kidney Dis
, vol.33
, Issue.4
, pp. 694-701
-
-
Bleyer, A.J.1
Burke, S.K.2
Dillon, M.3
Garrett, B.4
Kant, K.S.5
Lynch, D.6
Rahman, S.N.7
Schoenfeld, P.8
Teitelbaum, I.9
Zeig, S.10
Slatopolsky, E.11
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24
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0041996365
-
First filing for Foznol (lanthanum carbonate) in Europe
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401854; March 14
-
401854 First filing for Foznol (lanthanum carbonate) in Europe. Shire Pharmaceuticals Group Plc Press Release 2001 March 14
-
(2001)
Shire Pharmaceuticals Group Plc Press Release
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-
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25
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0042497179
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Shire files for European approval of Foznol licensed from AnorMED
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401901; March 14
-
401901 Shire files for European approval of Foznol licensed from AnorMED. AnorMED Inc Press Release 2001 March 14
-
(2001)
AnorMED Inc Press Release
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-
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26
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0038114572
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Healthy Mid-caps, Pan-European opportunities
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424603; September 25
-
424603 Healthy Mid-caps, Pan-European opportunities. Blum H Deutsche Banc Alex Brown - Europe 2001 September 25
-
(2001)
Deutsche Banc Alex Brown - Europe
-
-
Blum, H.1
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27
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0042497149
-
AnorMED announces positive US phase III clinical data indicate Foznol is effective and well-tolerated
-
425705; October 15
-
425705 AnorMED announces positive US phase III clinical data indicate Foznol is effective and well-tolerated. AnorMED Inc Press Release 2001 October 15
-
(2001)
AnorMED Inc Press Release
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-
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28
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0042997903
-
Pharma/Biotechs: Flight to quality
-
425842; October 01
-
425842 Pharma/Biotechs: Flight to quality. Herrmann M Ing Barings 2001 October 01
-
(2001)
Ing Barings
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Herrmann, M.1
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30
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0041996339
-
Successful ADDERALL XR launch provides Shire with strong platform for mid to long term growth
-
450140; May 01
-
450140 Successful ADDERALL XR launch provides Shire with strong platform for mid to long term growth. Shire Pharmaceuticals Group Plc Press Release 2002 May 01
-
(2002)
Shire Pharmaceuticals Group Plc Press Release
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-
-
31
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0041996335
-
Fosrenol renal bone disease study results
-
453948; June 07
-
453948 Fosrenol renal bone disease study results. Shire Pharmaceuticals Group Plc Press Release 2002 June 07
-
(2002)
Shire Pharmaceuticals Group Plc Press Release
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-
-
32
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0042497148
-
Fosrenol, a treatment for kidney disease, submitted for approval in Canada
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454144; June 10
-
454144 Fosrenol, a treatment for kidney disease, submitted for approval in Canada. AnorMED Inc Press Release 2002 June 10
-
(2002)
AnorMED Inc Press Release
-
-
-
33
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0041495313
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Fosrenol reduces damaging high levels of phosphate in end-stage kidney disease patients
-
468945; November 03
-
468945 Fosrenol reduces damaging high levels of phosphate in end-stage kidney disease patients. Shire Pharmaceuticals Group Plc Press Release 2002 November 03
-
(2002)
Shire Pharmaceuticals Group Plc Press Release
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-
-
34
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0141824840
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Shire Pharmaceuticals Group plc: Third quarter 2002 results in line with expectations
-
469316; November 06
-
469316 Shire Pharmaceuticals Group plc: Third quarter 2002 results in line with expectations. Shire Pharmaceuticals Group Plc Press Release 2002 November 06
-
(2002)
Shire Pharmaceuticals Group Plc Press Release
-
-
-
35
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0042497147
-
Safety profile of lanthanum carbonate in hemodialysis patients: Results from a phase III US study
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476097
-
476097 Safety profile of lanthanum carbonate in hemodialysis patients: Results from a phase III US study. Joy MS, Finn WF Pharmacotherapy 2002 22 10 1353
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(2002)
Pharmacotherapy
, vol.22
, Issue.10
, pp. 1353
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Joy, M.S.1
Finn, W.F.2
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36
-
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0042497147
-
Results of a randomized, phase III, dose-titration, parallel group study of lanthanum carbonate for reduction and maintenance of serum phosphate in chronic hemodialysis patients
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476101
-
476101 Results of a randomized, phase III, dose-titration, parallel group study of lanthanum carbonate for reduction and maintenance of serum phosphate in chronic hemodialysis patients. Joy MS, Finn WF Pharmacotherapy 2002 22 10 1353
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(2002)
Pharmacotherapy
, vol.22
, Issue.10
, pp. 1353
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-
Joy, M.S.1
Finn, W.F.2
-
37
-
-
0036020909
-
Management of hyperphosphatemia of chronic kidney disease: Lessons from the past and future directions
-
476102
-
476102 Management of hyperphosphatemia of chronic kidney disease: Lessons from the past and future directions. Malluche HH, Mawad H Nephrol Dial Transplant 2002 17 7 1170-1175
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(2002)
Nephrol Dial Transplant
, vol.17
, Issue.7
, pp. 1170-1175
-
-
Malluche, H.H.1
Mawad, H.2
-
38
-
-
7444231391
-
Fosrenol (lanthanum carbonate) vs. calcium carbonate for the treatment of hyperphosphatemia: A comparison of the effects on bone using biopsy examination
-
476104; Abs 769A
-
476104 Fosrenol (lanthanum carbonate) vs. calcium carbonate for the treatment of hyperphosphatemia: A comparison of the effects on bone using biopsy examination. J Am Soc Nephrol 2002 13 Abs 769A
-
(2002)
J Am Soc Nephrol
, vol.13
-
-
De Broe, M.E.1
-
39
-
-
0038125335
-
Fosrenol: A novel non-calcium, non-aluminum phosphate binder: Is well tolerated when given during or after food intake
-
476105; Abs 751A
-
476105 Fosrenol: A novel non-calcium, non-aluminum phosphate binder: Is well tolerated when given during or after food intake. Stewart AJ J Am Soc Nephrol 2002 13 Abs 751A
-
(2002)
J Am Soc Nephrol
, vol.13
-
-
Stewart, A.J.1
-
40
-
-
0037787626
-
Low systemic absorption of lanthanum and excellent tolerability during administration of 3 g of lanthanum as Fosrenol for 5 days
-
476123; Abs 751A
-
476123 Low systemic absorption of lanthanum and excellent tolerability during administration of 3 g of lanthanum as Fosrenol for 5 days. Fiddler G J Am Soc Nephrol 2002 13 Abs 751A
-
(2002)
J Am Soc Nephrol
, vol.13
-
-
Fiddler, G.1
-
41
-
-
0038464435
-
Fosrenol (lanthanum carbonate) does not affect the pharmacokinetics of concomitant treatment with warfarin
-
476124
-
476124 Fosrenol (lanthanum carbonate) does not affect the pharmacokinetics of concomitant treatment with warfarin. Fiddler G J Am Soc Nephrol 2002 13 749A-750A
-
(2002)
J Am Soc Nephrol
, vol.13
-
-
Fiddler, G.1
-
42
-
-
0038464435
-
Fosrenol (lanthanum carbonate) does not affect the pharmacokinetics of concomitant treatment with digoxin
-
476125; Abs 749A
-
476125 Fosrenol (lanthanum carbonate) does not affect the pharmacokinetics of concomitant treatment with digoxin. Fiddler G J Am Soc Nephrol 2002 13 Abs 749A
-
(2002)
J Am Soc Nephrol
, vol.13
-
-
Fiddler, G.1
-
43
-
-
0038691878
-
Fosrenol, a novel non-calcium, non-aluminum phosphate binder, has a good safety and efficacy profile in the long-term treatment of hyperphosphatemia in hemodialysis patients
-
476127; Abs 386A
-
476127 Fosrenol, a novel non-calcium, non-aluminum phosphate binder, has a good safety and efficacy profile in the long-term treatment of hyperphosphatemia in hemodialysis patients. Joy MS, Finn WF J Am Soc Nephrol 2002 13 Abs 386A
-
(2002)
J Am Soc Nephrol
, vol.13
-
-
Joy, M.S.1
Finn, W.F.2
-
44
-
-
0038125331
-
Administration of a novel phosphate binder, Fosrenol, with food is associated with good tolerability and low systemic absorption
-
476128; Abs 386A
-
476128 Administration of a novel phosphate binder, Fosrenol, with food is associated with good tolerability and low systemic absorption. Stewart J, Frazer N J Am Soc Nephrol 2002 13 Abs 386A
-
(2002)
J Am Soc Nephrol
, vol.13
-
-
Stewart, J.1
Frazer, N.2
-
45
-
-
0038802272
-
Fosrenol (lanthanum carbonate) is well tolerated in patients requiring hemodialysis: Results of a phase I clinical trial
-
476129; Abs 386A
-
476129 Fosrenol (lanthanum carbonate) is well tolerated in patients requiring hemodialysis: Results of a phase I clinical trial. Sack M, Frazer N J Am Soc Nephrol 2002 13 Abs 386A
-
(2002)
J Am Soc Nephrol
, vol.13
-
-
Sack, M.1
Frazer, N.2
-
46
-
-
0042497146
-
The novel, non-aluminum, non-calcium phosphate binder, Fosrenol, is an effective treatment for hyperphosphatemia and has a good safety profile
-
476130
-
476130 The novel, non-aluminum, non-calcium phosphate binder, Fosrenol, is an effective treatment for hyperphosphatemia and has a good safety profile. Hutchison AJ J Am Soc Nephrol 2002 13 385A-386A
-
(2002)
J Am Soc Nephrol
, vol.13
-
-
Hutchison, A.J.1
-
47
-
-
0042497151
-
The use of lanthanum carbonate as a novel phosphate binder in maintenance dialysis patients
-
476131
-
476131 The use of lanthanum carbonate as a novel phosphate binder in maintenance dialysis patients. Sikole A, Spasovski G, Gelev S, Grozdanovski R, Amitov V, D'Haese P, De Broe M Nephrol Dial Transplant 2002 17 1 14-17
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(2002)
Nephrol Dial Transplant
, vol.17
, Issue.1
, pp. 14-17
-
-
Sikole, A.1
Spasovski, G.2
Gelev, S.3
Grozdanovski, R.4
Amitov, V.5
D'Haese, P.6
De Broe, M.7
-
48
-
-
0000265209
-
An assessment of the effects of lanthanum on bone in a chronic renal failure (CRF) rat model
-
476132; Abs 740A
-
476132 An assessment of the effects of lanthanum on bone in a chronic renal failure (CRF) rat model. Behets GJ, Dams G, Damment S, D'Haese PC, De Broe ME J Am Soc Nephrol 2001 12 Abs 740A
-
(2001)
J Am Soc Nephrol
, vol.12
-
-
Behets, G.J.1
Dams, G.2
Damment, S.3
D'Haese, P.C.4
De Broe, M.E.5
-
49
-
-
0000581934
-
Results of a randomized, phase III, dose-titration, parallel group study of lanthanum carbonate for reduction and maintenance of serum phosphate in chronic hemodialysis patients
-
476133; Abs 388A
-
476133 Results of a randomized, phase III, dose-titration, parallel group study of lanthanum carbonate for reduction and maintenance of serum phosphate in chronic hemodialysis patients. Joy MS, Finn WF J Am Soc Nephrol 2001 12 Abs 388A
-
(2001)
J Am Soc Nephrol
, vol.12
-
-
Joy, M.S.1
Finn, W.F.2
-
50
-
-
1842508895
-
An assessment of the effects of lanthanum on bone in a chronic renal failure rat model
-
476134; Abs 27
-
476134 An assessment of the effects of lanthanum on bone in a chronic renal failure rat model. Behets GJ, Dams G, D'Haese PC, Damment S, De Broe ME Nephrol Dial Transplant 2001 16 6 Abs 27
-
(2001)
Nephrol Dial Transplant
, vol.16
, pp. 6
-
-
Behets, G.J.1
Dams, G.2
D'Haese, P.C.3
Damment, S.4
De Broe, M.E.5
-
51
-
-
4243339471
-
Lanthanum carbonate: A novel non-calcemic phosphate binder in dialysis patients
-
476135; Abs 557A
-
476135 Lanthanum carbonate: A novel non-calcemic phosphate binder in dialysis patients. Albaaj F, Hutchison AJ J Am Soc Nephrol 2000 11 Abs 557A
-
(2000)
J Am Soc Nephrol
, vol.11
-
-
Albaaj, F.1
Hutchison, A.J.2
-
52
-
-
1842508861
-
Lanthanum carbonate: A novel non-calcemic phosphate binder in dialysis patients
-
476137; Abs 113
-
476137 Lanthanum carbonate: A novel non-calcemic phosphate binder in dialysis patients. Hutchison AJ Nephrol Dial Transplant 2000 15 9 Abs 113
-
(2000)
Nephrol Dial Transplant
, vol.15
, pp. 9
-
-
Hutchison, A.J.1
-
53
-
-
0000850920
-
Results of a randomized dose-ranging, placebo controlled study of lanthanum carbonate for reduction of serum phosphate in chronic renal failure patients receiving hemodialysis
-
476141; Abs 261A
-
476141 Results of a randomized dose-ranging, placebo controlled study of lanthanum carbonate for reduction of serum phosphate in chronic renal failure patients receiving hemodialysis. Finn WF, Joy MS, Hladik GA J Am Soc Nephrol 1999 10 Abs 261A
-
(1999)
J Am Soc Nephrol
, vol.10
-
-
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