Opposing changes in osteocalcin levels in bone vs serum during the acquisition of peak bone density in C3H/HeJ and C57BL/6J mice

Calcified Tissue International

Volumn 71, Issue 5, 2002, Pages 416-420

  Li, X ^a   Srivastava, A K ^a   Gu, W ^a   Masinde, G ^a   Mohan, S ^a   Baylink, D J ^a  

^a LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Bone density; Circulatory osteocalcin; Inbred mouse; Skeletal osteocalcin

Indexed keywords

MESSENGER RNA; OSTEOCALCIN; PLASMA PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE; BONE DENSITY; BONE MASS; BONE MINERAL; CONTROLLED STUDY; CORRELATION ANALYSIS; CREATININE BLOOD LEVEL; HEREDITY; INBRED STRAIN; MOUSE; NONHUMAN; OSSIFICATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN METABOLISM; PROTEIN SECRETION; TIME;

AGING; ANIMALS; BONE DENSITY; CREATININE; DNA PRIMERS; FEMUR; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; OSTEOCALCIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SPECIES SPECIFICITY;

EID: 0042164734     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00223-001-1106-y     Document Type: Article

References (13)

1. Thomas GP, Bourne A, Eisman JA, Gardiner EM (2000) Species-divergent regulation of human and mouse osteocalcin genes by calciotropic hormones. Exp Cell Res 258:395-402
2. Calvo MS, Eyre DR, Gundberg CM (1996) Molecular basis and clinical application of biological markers of bone turnover. Endocr Rev 17:333-368
3. Dimai HP, Linkhart TA, Linkhart SG, Donahue LR, Beamer WG, Rosen CJ, Farley JR, Baylink DJ (1998) Alkaline phosphatase levels and osteoprogenitor cell numbers suggest bone formation may contribute to peak bone density differences between two inbred strains of mice. Bone 22:211-216
4. Richman C, Kutilek S, Miyakoshi N, Srivastava AK, Beamer W, Donahue LR, Rosen C, Wergedal J, Baylink DJ, Mohan S (2001) Postnatal and pubertal skeletal changes contribute predominantly to the differences in peak bone density between C3H/HeJ and C57BL/6J mice. J Bone Miner Res 16:386-397
5. Sheng MHC, Baylink DJ, Beamer WG, Donahue LR, Rosen CJ, Lau KHW, Wergedal JE (1999) Histomorphometric studies show that bone formation and bone mineral apposition rates are greater in C3H/HeJ (high-density) than C57BL/6J (low-density) mice during growth. Bone 25:421-429
6. Linkhart TA, Linkhart SG, Kodama Y, Parley JR, Dimai HP, Wright KR, Wergedal JE, Sheng M, Beamer WG, Donahue LR, Rosen CJ, Baylink DJ (1999) Osteoclast formation in bone marrow cultures from two inbred strains of mice with different bone density. J Bone Miner Res 14:39-46
7. Carpenter TO, Moltz KG, Ellis B, Andreoli M, McCarthy TL, Centrella M, Bryan D, Gundberg CM (1998) Osteocalcin production in primary osteoblast cultures derived from normal and Hyp mice. Endocrinology 139:35-43
8. Carpenter TO, Gundberg CM (1996) Osteocalcin abnormalities in Hyp mice reflect altered genetic expression and are not due to altered clearance, affinity for mineral, or ambient phosphorus levels. Endocrinilogy 137(12):5213-5219
9. Carpenter TO, Moltz KC, Ellis B, Andreoli M, McCarthy TL, Centrella M, Bryan D, Gundberg CM (1998) Osteocalcin production in primary osteoblast cultures derived from normal and Hyp mice. Endocrinilogy 139(1):35-43
10. Srivastava AK, Castillo G, Wergedal JE, Mohan S, Baylink DJ (2000) Development and application of a synthetic peptide-based osteocalcin assay for the measurement of bone formation in mouse serum. Calcif Tissue Int 66:255-259
11. Beamer WG, Shultz KL, Churchill GA, Frankel WN, Baylink DJ, Rosen CJ, Donahue LR (1999) Quantitative trait loci for bone density in C57BI76J and CAST/EiJ inbred mice. Mamm Genome 10:1043-1049
12. Nagy RN, Prince CW, Li J (2001) Validation of peripheral dual-energy X-ray absorptiometery for the measurement of bone mineral in intact and excised long bones of rats. J Bone Miner Res 16(9):1682-1687
13. Beamer WG, Donahue LR, Rosen CJ, Baylink DJ (1996) Genetic variability in adult bone density among inbred strains of mice. Bone 18(5):397-403