Chiral HPLC method for chiral purity determination of paroxetine drug substance

Chirality

Volumn 15, Issue 7, 2003, Pages 600-604

  Zukowski, Janusz ^a   Brightwell, Malcolm ^a   De Biasi, Vern ^b  

^a GLAXOSMITHKLINE   (United Kingdom)

^b GSK   (Italy)

Author keywords

Chiral HPLC; Chiral purity; Paroxetine

Indexed keywords

ALCOHOL; ANTIDEPRESSANT AGENT; BRL 29679; BRL 39623; BRL 55188; HEXANE; PAROXETINE; SB 242670; SB 242673; SB 424961; TRIFLUOROACETIC ACID; UNCLASSIFIED DRUG; WATER;

ACCURACY; ARTICLE; CHIRAL CHROMATOGRAPHY; DRUG IMPURITY; DRUG PURITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REPRODUCIBILITY; SEPARATION TECHNIQUE; TRANS ISOMER;

ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; PAROXETINE; SENSITIVITY AND SPECIFICITY; STEREOISOMERISM;

EID: 0042164663     PISSN: 08990042     EISSN: None     Source Type: Journal    
DOI: 10.1002/chir.10250     Document Type: Article

References (3)

1. Ferretti R, Gallinella B, La Torre F, Turchetto L. Validated chiral high-performance liquid chromatographic method for the determination of trans-(-)-paroxetine and its enantiomer in bulk and pharmaceutical formulations. J Chromatogr 1998;710:157-164.
2. Karlsson A, Pettersson C, Bjoerkman S. Determination of (R)- and (S)-propranolol in plasma by high-performance liquid chromatography using N-benzoxycarbonylglycyl-L-proline as chiral selector in the mobile phase. J Chromatogr 1989;494:157-171.
3. Ning JG. Water as polar modifier in normal phase chiral separation of 2-oxo-3-piperidineacetamide analogue. Enantiomer 2000;5:323-328.